{"id":17173,"date":"2024-03-28T04:32:29","date_gmt":"2024-03-28T04:32:29","guid":{"rendered":"https:\/\/fipmed.co\/%d9%85%d9%88%d9%84%d9%86%d9%88%d8%a8%d9%8a%d8%b1%d8%a7%d9%81%d9%8a%d8%b1-%d9%83%d8%af%d9%88%d8%a7%d8%a1-%d8%ab%d8%a7%d9%84%d8%ab-%d9%85%d8%b6%d8%a7%d8%af-%d9%84%d9%84%d9%81%d9%8a%d8%b1%d9%88%d8%b3\/"},"modified":"2024-03-28T04:32:29","modified_gmt":"2024-03-28T04:32:29","slug":"%d9%85%d9%88%d9%84%d9%86%d9%88%d8%a8%d9%8a%d8%b1%d8%a7%d9%81%d9%8a%d8%b1-%d9%83%d8%af%d9%88%d8%a7%d8%a1-%d8%ab%d8%a7%d9%84%d8%ab-%d9%85%d8%b6%d8%a7%d8%af-%d9%84%d9%84%d9%81%d9%8a%d8%b1%d9%88%d8%b3","status":"publish","type":"page","link":"https:\/\/fipmed.co\/ar\/%d9%85%d9%88%d9%84%d9%86%d9%88%d8%a8%d9%8a%d8%b1%d8%a7%d9%81%d9%8a%d8%b1-%d9%83%d8%af%d9%88%d8%a7%d8%a1-%d8%ab%d8%a7%d9%84%d8%ab-%d9%85%d8%b6%d8%a7%d8%af-%d9%84%d9%84%d9%81%d9%8a%d8%b1%d9%88%d8%b3\/","title":{"rendered":"Molnupiravir \u0643\u062f\u0648\u0627\u0621 \u062b\u0627\u0644\u062b \u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0644\u0639\u0644\u0627\u062c FIP"},"content":{"rendered":"<p class=\"p2\"><span class=\"s1\"><span class=\"Apple-converted-space\">\u064a\u0641\u0643\u0631 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0623\u0635\u062d\u0627\u0628 \u0627\u0644\u0642\u0637\u0637 \u0645\u0646 FIP \u0641\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 Molnupiravir \u0648GS441524 \u0639\u0646\u062f\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0627\u0644\u0623\u0645\u0631 \u0628\u0645\u0639\u0627\u0644\u062c\u0629 \u0642\u0637\u062a\u0647\u0645. \u0627\u0644\u062d\u0642\u064a\u0642\u0629 \u0647\u064a \u0623\u0646 \u0643\u0644\u0627 \u0627\u0644\u062e\u064a\u0627\u0631\u064a\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u064a\u0646 \u0641\u0639\u0627\u0644\u0627\u0646 \u0641\u064a \u0639\u0644\u0627\u062c FIP \u0648\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0639\u0642\u0627\u0631 Molnupiravir \u0634\u062f\u064a\u062f \u0627\u0644\u0633\u0645\u064a\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647 \u062f\u0648\u0627\u0621 \u062e\u0637\u064a\u0631 \u0644\u0644\u063a\u0627\u064a\u0629 \u0644\u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0645\u0646 \u0628\u064a\u0646\u0647\u0627\u060c \u062e\u0627\u0635\u0629 \u0639\u0646\u062f\u0645\u0627 \u062a\u062d\u062a\u0627\u062c \u0625\u0644\u0649 \u0639\u0644\u0627\u062c \u0642\u0637\u062a\u0643 \u0644\u0645\u062f\u0629 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627\u060c \u0648\u0644\u0627 \u064a\u064f\u0646\u0635\u062d \u0628\u062a\u0639\u0631\u064a\u0636\u0647\u0627 \u0644\u062f\u0648\u0627\u0621 \u0639\u0627\u0644\u064a \u0627\u0644\u0633\u0645\u064a\u0629 \u0644\u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629.  <\/span><\/span><\/p>\n<p class=\"p2\"><strong><span class=\"s1\"><span class=\"Apple-converted-space\">\u0641\u064a\u0645\u0627 \u064a\u0644\u064a \u062a\u0642\u0631\u064a\u0631 &#8220;Molnupiravir \u0643\u062f\u0648\u0627\u0621 \u062b\u0627\u0644\u062b \u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0644\u0639\u0644\u0627\u062c FIP&#8221; \u0645\u0646 \u0627\u0644\u062f\u0643\u062a\u0648\u0631<\/span><\/span> <i>Niels C. Pedersen DVM\u060c \u062f\u0643\u062a\u0648\u0631\u0627\u0647 <span class=\"Apple-converted-space\">\u0641\u064a<\/span><\/i> <i>20 \u0623\u0643\u062a\u0648\u0628\u0631 2021<span class=\"Apple-converted-space\"> <\/span><\/i> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p2\"><span class=\"s2\">Beta-d-N4-hydroxycytidine\u060c \u0648\u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u0633\u0627\u0639\u062f \u0644\u0639\u0642\u0627\u0631 Molnupiravir\u060c \u0647\u0648<\/span> \u062c\u0632\u064a\u0621 \u0635\u063a\u064a\u0631 (\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u0632\u064a\u062f) \u062a\u0645\u062a \u062f\u0631\u0627\u0633\u062a\u0647 \u0641\u064a \u0623\u0648\u0627\u062e\u0631 \u0627\u0644\u0633\u0628\u0639\u064a\u0646\u064a\u0627\u062a \u0641\u064a \u0627\u0644\u0627\u062a\u062d\u0627\u062f \u0627\u0644\u0633\u0648\u0641\u064a\u062a\u064a \u0627\u0644\u0642\u062f\u064a\u0645 \u0643\u062c\u0632\u0621 \u0645\u0646 \u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0623\u0633\u0644\u062d\u0629 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 [2]. \u0643\u0627\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0645\u0631\u0627\u0636 \u0645\u062b\u0644 \u0627\u0644\u062c\u062f\u0631\u064a \u0643\u0633\u0644\u0627\u062d \u0628\u0645\u062b\u0627\u0628\u0629 \u062e\u0648\u0641 \u0639\u0627\u0644\u0645\u064a\u060c \u0644\u0643\u0646 \u0645\u062e\u0627\u0637\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062c\u062f\u0631\u064a \u0644\u0647\u0630\u0627 \u0627\u0644\u063a\u0631\u0636 \u0643\u0627\u0646\u062a \u0643\u0628\u064a\u0631\u0629 \u0644\u0644\u063a\u0627\u064a\u0629. \u062a\u0645 \u0627\u0644\u0642\u0636\u0627\u0621 \u0639\u0644\u0649 \u0627\u0644\u062c\u062f\u0631\u064a \u0645\u0646 \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u0648\u062a\u0645 \u062a\u062f\u0645\u064a\u0631 \u062c\u0645\u064a\u0639 \u0645\u062e\u0632\u0648\u0646\u0627\u062a\u0647 \u062a\u0642\u0631\u064a\u0628\u064b\u0627\u060c \u0648\u062a\u0645 \u062d\u0638\u0631 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b. \u0623\u062f\u0649 \u0630\u0644\u0643 \u0625\u0644\u0649 \u0642\u064a\u0627\u0645 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0648\u0627\u0644\u0627\u062a\u062d\u0627\u062f \u0627\u0644\u0633\u0648\u0641\u064a\u062a\u064a \u0628\u0627\u0644\u0628\u062d\u062b \u0641\u064a \u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0623\u062e\u0631\u0649 \u0643\u0623\u0633\u0644\u062d\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u0645\u0636\u0627\u062f\u0627\u062a \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0644\u0644\u062f\u0641\u0627\u0639 \u0636\u062f\u0647\u0627. \u0643\u0627\u0646 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062f\u0645\u0627\u063a \u0648\u0627\u0644\u0646\u062e\u0627\u0639 \u0627\u0644\u062e\u064a\u0644\u064a \u0627\u0644\u0641\u0646\u0632\u0648\u064a\u0644\u064a (VEEV) \u0623\u062d\u062f \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0644\u062a\u064a \u062a\u0645 \u0627\u0639\u062a\u0628\u0627\u0631\u0647\u0627 \u0633\u0644\u0627\u062d\u064b\u0627 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u064b\u0627 [3]. \u064a\u0646\u062a\u0642\u0644 VEEV \u0625\u0644\u0649 \u0627\u0644\u0628\u0634\u0631 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0644\u062f\u063a\u0627\u062a \u0627\u0644\u0628\u0639\u0648\u0636\u060c \u0648\u064a\u0633\u0628\u0628 \u062d\u0645\u0649 \u0634\u062f\u064a\u062f\u0629 \u0648\u0635\u062f\u0627\u0639\u064b\u0627 \u0648\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062f\u0645\u0627\u063a \u0648\u062a\u0648\u0631\u0645\u064b\u0627 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0645\u0645\u064a\u062a\u064b\u0627. \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 Beta-d-N4-hydroxycytidine \u0644\u064a\u0633 \u0641\u0642\u0637 \u0644\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 VEEV\u060c \u0648\u0644\u0643\u0646 \u0623\u064a\u0636\u064b\u0627 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0623\u0644\u0641\u0627\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0625\u064a\u0628\u0648\u0644\u0627\u060c \u0648\u0627\u0644\u0634\u064a\u0643\u0648\u0646\u063a\u0648\u0646\u064a\u0627\u060c \u0648\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0623\u0646\u0641\u0644\u0648\u0646\u0632\u0627\u060c \u0648\u0627\u0644\u0646\u0648\u0631\u0648\u0641\u064a\u0631\u0648\u0633\u060c \u0648\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0633\u0647\u0627\u0644 \u0627\u0644\u0628\u0642\u0631\u064a\u060c \u0648\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f C\u060c \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0645\u062e\u0644\u0648\u064a \u0627\u0644\u062a\u0646\u0641\u0633\u064a.[3-8] . \u0623\u0648\u0644 \u062a\u0642\u0631\u064a\u0631 \u0639\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0645\u062b\u0628\u0637 \u0644\u0628\u064a\u062a\u0627-\u062f- <span class=\"s2\">\u0625\u06464-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0633\u064a\u062a\u064a\u062f\u064a\u0646 \u0639\u0644\u0649<\/span> \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0628\u0634\u0631\u064a NL63 \u0643\u0627\u0646 \u0641\u064a \u0639\u0627\u0645 2006 [9]. \u0648\u0642\u062f \u0623\u0643\u062f\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u062a\u0623\u062b\u064a\u0631\u0647 \u0627\u0644\u0645\u062b\u0628\u0637 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0648\u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629 [8].<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u062c\u0632\u0621 \u0645\u0647\u0645 \u0645\u0646 \u0627\u0644\u062a\u0627\u0631\u064a\u062e \u0627\u0644\u062d\u062f\u064a\u062b \u0644\u0628\u064a\u062a\u0627-\u062f-\u06464-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0633\u064a\u062a\u064a\u062f\u064a\u0646 \u064a\u0623\u062a\u064a \u0645\u0646 \u0645\u0639\u0647\u062f \u0625\u064a\u0645\u0648\u0631\u064a \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 (EIDD) [1]\u060c \u0648\u0643\u0627\u0646 \u0627\u0633\u0645\u0647 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a EIDD-1931. \u0642\u062f\u0645\u062a \u062d\u0643\u0648\u0645\u0629 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u062f\u0639\u0645\u064b\u0627 \u0645\u0627\u0644\u064a\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0636\u062f \u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0623\u0644\u0641\u0627 \u0641\u064a \u0645\u0624\u0633\u0633\u0627\u062a \u0645\u062b\u0644 \u0625\u064a\u0645\u0648\u0631\u064a \u0645\u0646\u0630 \u0639\u0627\u0645 2004\u060c \u0645\u0639 \u062f\u0639\u0645 \u0645\u0627\u0644\u064a \u0643\u0628\u064a\u0631 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646.[10] . \u0642\u062f\u0645\u062a \u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u062d\u062f \u0645\u0646 \u0627\u0644\u062a\u0647\u062f\u064a\u062f\u0627\u062a \u0627\u0644\u062f\u0641\u0627\u0639\u064a\u0629 \u0627\u0644\u062f\u0639\u0645 \u0627\u0644\u0645\u0624\u0633\u0633\u064a \u0641\u064a \u0639\u0627\u0645 2014 \u0628\u0647\u062f\u0641 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u0645\u0631\u0643\u0628 \u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0636\u062f VEEV \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0623\u0644\u0641\u0627 \u0627\u0644\u0623\u062e\u0631\u0649. \u062a\u0645\u062a \u062a\u063a\u0637\u064a\u0629 &#8220;N4-Hydroxycytidine \u0648\u0645\u0634\u062a\u0642\u0627\u062a\u0647 \u0648\u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0647&#8221; \u0628\u0637\u0644\u0628 \u0628\u0631\u0627\u0621\u0629 \u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0639 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0631\u0642\u0645 2016\/106050 A1 \u0641\u064a \u0639\u0627\u0645 2016[11] . \u062c\u0627\u0621 \u062a\u0645\u0648\u064a\u0644 \u0625\u0636\u0627\u0641\u064a \u0641\u064a \u0639\u0627\u0645 2019 \u0645\u0646 \u0627\u0644\u0645\u0639\u0647\u062f \u0627\u0644\u0648\u0637\u0646\u064a \u0644\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0639\u062f\u064a\u0629 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0628\u062d\u062b \u062d\u0648\u0644 \u0639\u0642\u0627\u0631 \u0623\u0648\u0644\u064a \u0645\u0633\u062a\u0631 \u0645\u0646 \u0628\u064a\u062a\u0627-\u062f-\u0625\u06464-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0633\u064a\u062a\u064a\u062f\u064a\u0646 (EIDD-2801) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0646\u0641\u0644\u0648\u0646\u0632\u0627[10] . \u0643\u0627\u0646 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0645\u0639\u0644\u0646 \u0645\u0646 \u0627\u0644\u062a\u0639\u062f\u064a\u0644\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 EIDD-2801 \u0647\u0648 \u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645\u060c \u0645\u0645\u0627 \u0633\u064a\u0633\u0645\u062d \u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0644\u0640 beta-d-N4-hydroxycytidine \u0628\u062a\u0643\u0648\u064a\u0646\u0647.<span class=\"s1\"><span class=\"Apple-converted-space\"> <\/span><\/span>\u064a\u062a\u0645 \u0625\u0639\u0637\u0627\u0624\u0647 \u0639\u0644\u0649 \u0634\u0643\u0644 \u0623\u0642\u0631\u0627\u0635 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u062d\u0642\u0646. \u062d\u062f\u062b \u062a\u062d\u0648\u0644 \u0641\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0628\u062d\u062b\u064a \u0645\u0646 \u0627\u0644\u0623\u0646\u0641\u0644\u0648\u0646\u0632\u0627 \u0625\u0644\u0649 SARS-II CoV \u0641\u064a 2019\/2020 [2]. \u062a\u0645 \u0645\u0646\u062d \u062a\u0633\u0648\u064a\u0642 EIDD-2801 \u062a\u062c\u0627\u0631\u064a\u064b\u0627 \u0625\u0644\u0649 \u0634\u0631\u0643\u0629 \u062a\u0627\u0628\u0639\u0629 \u0644\u0634\u0631\u0643\u0629 Emory \u062a\u062f\u0639\u0649 Ridgeway Biotherapeutics\u060c \u0648\u0627\u0644\u062a\u064a \u0627\u0634\u062a\u0631\u0643\u062a \u0628\u0639\u062f \u0630\u0644\u0643 \u0645\u0639 \u0634\u0631\u0643\u0629 Merck \u0641\u064a \u0639\u0645\u0644\u064a\u0629 \u0645\u0648\u0627\u0641\u0642\u0629 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0637\u0648\u064a\u0644\u0629 \u0648\u0627\u0644\u0645\u0643\u0644\u0641\u0629. \u062a\u0645\u062a \u062a\u0633\u0645\u064a\u0629 \u0646\u0633\u062e\u0629 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u064a\u062f\u0627\u0646\u064a \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0644\u0640 EIDD-2081 \u0628\u0627\u0633\u0645 Molnupiravir.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">Beta-d-N4-hydroxycytidine <span class=\"s2\">\u060c \u0627\u0644\u0639\u0646\u0635\u0631 \u0627\u0644\u0646\u0634\u0637 \u0641\u064a Molnupiravir\u060c<\/span> \u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0634\u0643\u0644\u064a\u0646 \u0639\u0644\u0649 \u0634\u0643\u0644 \u062a\u0648\u062a\u0648\u0645\u0631\u0632. \u0641\u064a \u0623\u062d\u062f \u0623\u0634\u0643\u0627\u0644\u0647\u060c \u064a\u062d\u0627\u0643\u064a \u0627\u0644\u0633\u064a\u062a\u064a\u062f\u064a\u0646\u060c \u0628\u0631\u0627\u0628\u0637\u0629 \u0648\u0627\u062d\u062f\u0629 \u0628\u064a\u0646 \u0627\u0644\u0643\u0631\u0628\u0648\u0646 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 N-OH. \u0648\u0641\u064a \u0634\u0643\u0644\u0647 \u0627\u0644\u0622\u062e\u0631\u060c \u0627\u0644\u0630\u064a \u064a\u062d\u0627\u0643\u064a \u0627\u0644\u064a\u0648\u0631\u064a\u062f\u064a\u0646\u060c \u0641\u0647\u0648 \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0623\u0648\u0643\u0633\u064a\u0645 \u0628\u0631\u0627\u0628\u0637\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0628\u064a\u0646 \u0627\u0644\u0643\u0631\u0628\u0648\u0646 \u0648\u0645\u062c\u0645\u0648\u0639\u0629 N-OH. \u0641\u064a \u0648\u062c\u0648\u062f \u0628\u064a\u062a\u0627-\u062f-\u06464-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0633\u064a\u062a\u064a\u062f\u064a\u0646\u060c \u064a\u0642\u0631\u0623\u0647 \u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a (RNA) \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0639\u0644\u0649 \u0623\u0646\u0647 \u064a\u0648\u0631\u064a\u062f\u064a\u0646 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0633\u064a\u062a\u064a\u062f\u064a\u0646 \u0648\u064a\u062f\u062e\u0644 \u0623\u062f\u064a\u0646\u0648\u0632\u064a\u0646 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u063a\u0648\u0627\u0646\u0648\u0632\u064a\u0646. \u064a\u0624\u062f\u064a \u0627\u0644\u062a\u0628\u062f\u064a\u0644 \u0628\u064a\u0646 \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0625\u0644\u0649 \u0639\u062f\u0645 \u0627\u0644\u062a\u0637\u0627\u0628\u0642 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0646\u0633\u062e\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u0637\u0641\u0631\u0627\u062a \u0639\u062f\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u060c \u0648\u0648\u0642\u0641 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 [8].<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0625\u0646 \u062a\u0637\u0648\u064a\u0631 Molnupiravir \u0645\u0646 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\u062e\u0637\u0631. \u0648\u062a\u062a\u0648\u0642\u0639 \u0634\u0631\u0643\u0629 \u0645\u064a\u0631\u0643 \u0625\u0646\u062a\u0627\u062c 10 \u0645\u0644\u0627\u064a\u064a\u0646 \u062f\u0648\u0631\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0628\u062d\u0644\u0648\u0644 \u0646\u0647\u0627\u064a\u0629 \u0639\u0627\u0645 2021\u060c \u0645\u0639 \u062a\u0648\u0642\u0639 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0641\u064a \u0639\u0627\u0645 2022. \u2026\u2026. . \u062a\u0644\u062a\u0632\u0645 \u0634\u0631\u0643\u0629 Merck \u0628\u062a\u0648\u0641\u064a\u0631 \u0627\u0644\u0648\u0635\u0648\u0644 \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0625\u0644\u0649 Molnupiravir \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u0625\u0630\u0627 \u062a\u0645 \u0627\u0644\u062a\u0631\u062e\u064a\u0635 \u0628\u0647 \u0623\u0648 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\u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639\u060c \u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Merck \u0633\u0627\u0628\u0642\u064b\u0627 \u0623\u0646 \u0627\u0644\u0634\u0631\u0643\u0629 \u0623\u0628\u0631\u0645\u062a \u0627\u062a\u0641\u0627\u0642\u064a\u0627\u062a \u062a\u0631\u062e\u064a\u0635 \u0637\u0648\u0639\u064a\u0629 \u063a\u064a\u0631 \u062d\u0635\u0631\u064a\u0629 \u0644\u0640 Molnupiravir \u0645\u0639 \u0627\u0644\u0634\u0631\u0643\u0627\u062a \u0627\u0644\u0645\u0635\u0646\u0639\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0644\u062a\u0633\u0631\u064a\u0639 \u062a\u0648\u0627\u0641\u0631 Molnupiravir \u0641\u064a \u0623\u0643\u062b\u0631 \u0645\u0646 100 \u062f\u0648\u0644\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 \u0648\u0645\u062a\u0648\u0633\u0637\u0629 \u0627\u0644\u062f\u062e\u0644 (LMICs). \u0628\u0639\u062f \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0627\u062a \u0623\u0648 \u062a\u0635\u0631\u064a\u062d \u0627\u0644\u0637\u0648\u0627\u0631\u0626 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0647\u064a\u0626\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0627\u0644\u0645\u062d\u0644\u064a\u0629.  <\/i>\u0648\u0645\u0646 \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u062c\u062d \u0623\u0646 \u064a\u0646\u0637\u0628\u0642 \u0647\u0630\u0627 &#8220;\u0627\u0644\u0643\u0631\u0645&#8221; \u0623\u064a\u0636\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u062a\u0645 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645\u0646\u0639 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0648\u0628\u0627\u0621 \u0643\u0648\u0641\u064a\u062f-19 \u0627\u0644\u062d\u0627\u0644\u064a \u0628\u0633\u0631\u0639\u0629 \u0645\u064a\u062f\u0627\u0646\u064a\u0629 \u0639\u0644\u0649 \u0645\u062f\u0649 \u0627\u0644\u0639\u0627\u0645\u064a\u0646 \u0627\u0644\u0645\u0627\u0636\u064a\u064a\u0646\u060c \u0648\u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0623\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0648\u0647\u0648 \u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631\u060c \u0641\u064a \u0648\u0642\u062a \u0642\u064a\u0627\u0633\u064a \u0644\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649. \u062a\u0645 \u0646\u0642\u0644 Molnupiravir \u0646\u062d\u0648 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0645\u0634\u0631\u0648\u0637\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0639\u0627\u0645 \u0627\u0644\u0645\u0627\u0636\u064a \u0643\u062f\u0648\u0627\u0621 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0632\u0644\u064a \u0644\u0644\u0639\u062f\u0648\u0649 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u0628\u0643\u0631\u0629[12] . \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u062a\u0645 \u062a\u0637\u0648\u064a\u0631 \u0645\u0631\u0643\u0628\u0627\u062a \u0641\u0639\u0627\u0644\u0629 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0641\u064a \u0648\u0642\u062a \u0633\u0627\u0628\u0642 \u0644\u0645\u0631\u0636 \u0622\u062e\u0631 \u0634\u0627\u0626\u0639 \u0648\u0634\u062f\u064a\u062f \u064a\u0635\u064a\u0628 \u0627\u0644\u0642\u0637\u0637\u060c \u0648\u0647\u0648 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0635\u0641\u0627\u0642 \u0627\u0644\u0645\u0639\u062f\u064a \u0644\u062f\u0649 \u0627\u0644\u0642\u0637\u0637 (FIP). \u062a\u0634\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u062b\u0628\u0637 \u0627\u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a (GC376)[13] \u0648\u0645\u062b\u0628\u0637 \u0628\u0648\u0644\u064a\u0645\u064a\u0631\u064a\u0632 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a (GS-441524) \u0648\u0647\u0648 \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0646\u0634\u0637 \u0645\u0646 \u0639\u0642\u0627\u0631 \u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631.[14] . \u0623\u062f\u0649 \u0627\u0644\u0646\u062c\u0627\u062d \u0641\u064a \u0639\u0644\u0627\u062c FIP \u0628\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0625\u0644\u0649 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u062d\u062f\u064a\u062b\u0629 \u0644\u0643\u0644 \u0645\u0646 EIDD-1931 \u0648EIDD-2801 \u0644\u0642\u062f\u0631\u062a\u0647\u0645\u0627 \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 FIPV \u0641\u064a \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0623\u0646\u0633\u062c\u0629.[15] . \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0627\u0644\u0641\u0639\u0627\u0644-50% (EC50) \u0644\u0640 EIDD-1931 \u0636\u062f FIPV \u0647\u0648 0.09 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631\u060c EIDD-2801 0.4 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 \u0648GS-441524 0.66 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631[15] .<strong>  \u062a\u0628\u0644\u063a \u0646\u0633\u0628\u0629 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0639\u0646\u062f 100 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 2.8 \u06483.8 \u06480 \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0648\u0644\u0630\u0644\u0643\u060c \u0641\u0625\u0646 EIDD-1931 \u0648-2801 \u0623\u0643\u062b\u0631 \u062a\u062b\u0628\u064a\u0637\u064b\u0627 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0628\u0642\u0644\u064a\u0644 \u0648\u0644\u0643\u0646\u0647\u0645\u0627 \u0623\u064a\u0636\u064b\u0627 \u0623\u0643\u062b\u0631 \u0633\u0645\u064a\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0645\u0646 GS-441524.<\/strong>  \u062a\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629 \u0625\u0644\u0649 \u0623\u0646 \u0643\u0644\u0627 \u0645\u0646 EIDD-1931 \u0648EIDD-2801 \u0645\u0631\u0634\u062d\u0627\u0646 \u0645\u0645\u062a\u0627\u0632\u0627\u0646 \u0623\u064a\u0636\u064b\u0627 \u0644\u0639\u0644\u0627\u062c FIP.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 EIDD-1931 \u0648EIDD-2801 \u064a\u062d\u0645\u0644\u0627\u0646 \u0648\u0639\u062f\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0644\u0639\u0644\u0627\u062c FIP\u060c \u0625\u0644\u0627 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0639\u0642\u0628\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u062c\u0639\u0644 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0642\u0627\u0646\u0648\u0646\u064a \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u063a\u064a\u0631 \u0645\u0631\u062c\u062d \u0641\u064a \u0623\u064a \u0648\u0642\u062a \u0642\u0631\u064a\u0628. \u062a\u0645 \u0628\u062d\u062b GS-441524\u060c \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0646\u0634\u0637 \u0644\u0640 Remdesivir\u060c \u0648\u0627\u0644\u062d\u0627\u0635\u0644 \u0639\u0644\u0649 \u0628\u0631\u0627\u0621\u0629 \u0627\u062e\u062a\u0631\u0627\u0639 \u0645\u0646 \u0642\u0628\u0644 \u0634\u0631\u0643\u0629 Gilead Sciences\u060c \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0640 FIP \u0642\u0628\u0644 \u0648\u0642\u062a \u0642\u0635\u064a\u0631 \u0645\u0646 \u0638\u0647\u0648\u0631 \u062c\u0627\u0626\u062d\u0629 Covid-19. \u0644\u0630\u0644\u0643\u060c \u0643\u0627\u0646 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0644\u0640 Remdesivir \u0636\u062f \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u064a\u0628\u0648\u0644\u0627 \u0648\u0644\u064a\u0633 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0634\u0628\u064a\u0647\u0629 \u0628\u0627\u0644\u0633\u0627\u0631\u0633 \u0647\u0648 \u0627\u0644\u0630\u064a \u062f\u0641\u0639 \u0625\u0644\u0649 \u0627\u0644\u0628\u062d\u062b \u0639\u0646 FIP[14] . \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u062a\u0645 \u0625\u062c\u0631\u0627\u0624\u0647\u0627 \u0628\u0627\u0644\u062a\u0639\u0627\u0648\u0646 \u0645\u0639 \u0639\u0644\u0645\u0627\u0621 \u0645\u0646 \u0634\u0631\u0643\u0629 Gilead Science\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u0634\u0631\u0643\u0629 \u0631\u0641\u0636\u062a \u062d\u0642\u0648\u0642 \u0627\u0644\u062d\u064a\u0648\u0627\u0646 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0640 GS-441524 \u0628\u0645\u062c\u0631\u062f \u0623\u0646 \u0623\u0635\u0628\u062d \u0645\u0646 \u0627\u0644\u0648\u0627\u0636\u062d \u0623\u0646 \u0647\u0646\u0627\u0643 \u0633\u0648\u0642\u064b\u0627 \u0623\u0643\u0628\u0631 \u0628\u0643\u062b\u064a\u0631 \u0644\u0640 Covid-19 \u0641\u064a \u0627\u0644\u0628\u0634\u0631.[16] . \u0648\u0628\u0627\u0644\u0645\u062b\u0644\u060c \u0641\u0625\u0646 \u0645\u062d\u0627\u0648\u0644\u0627\u062a\u064a \u0639\u0644\u0649 \u0645\u062f\u0649 \u0627\u0644\u0633\u0646\u062a\u064a\u0646 \u0623\u0648 \u0627\u0644\u062b\u0644\u0627\u062b \u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0645\u0627\u0636\u064a\u0629 \u0645\u0639 Emory \u0648Ridgeback Biotherapeutics \u0648\u0627\u0644\u0642\u0633\u0645 \u0627\u0644\u0628\u064a\u0637\u0631\u064a \u0641\u064a \u0634\u0631\u0643\u0629 Merck \u0644\u0644\u0628\u062d\u062b \u0639\u0646 EIDD-1931 \u0648EIDD-2801 \u0645\u0646 \u0623\u062c\u0644 FIP \u0641\u064a \u0627\u0644\u0642\u0637\u0637 \u0625\u0645\u0627 \u0623\u0646\u0647\u0627 \u0644\u0645 \u064a\u062a\u0645 \u0627\u0644\u0631\u062f \u0639\u0644\u064a\u0647\u0627 \u0623\u0648 \u062a\u0645 \u0631\u0641\u0636\u0647\u0627\u060c \u0645\u0645\u0627 \u0644\u0627 \u0634\u0643 \u0641\u064a\u0647 \u0644\u0623\u0633\u0628\u0627\u0628 \u0645\u0645\u0627\u062b\u0644\u0629 \u0644\u0633\u0628\u0628 \u062c\u0644\u0639\u0627\u062f \u0631\u0641\u0636 \u0645\u0646\u062d \u062d\u0642\u0648\u0642 \u0627\u0644\u062d\u064a\u0648\u0627\u0646 \u0644\u0640 GS-441524. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0627\u0644\u062d\u0627\u062c\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0627\u0644\u0643\u0628\u064a\u0631\u0629 \u0644\u0639\u0644\u0627\u062c FIP \u063a\u0630\u062a \u0628\u0633\u0631\u0639\u0629 \u0633\u0648\u0642\u064b\u0627 \u063a\u064a\u0631 \u0645\u0639\u062a\u0645\u062f \u0644\u0640 GS-441524 \u062e\u0627\u0631\u062c \u0627\u0644\u0635\u064a\u0646. \u0648\u0642\u062f \u0623\u062f\u062a \u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u062c\u0629 \u0646\u0641\u0633\u0647\u0627 \u0625\u0644\u0649 \u0639\u0644\u0627\u062c FIP \u0645\u0624\u062e\u0631\u064b\u0627 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 Molnupiravir \u0643\u0639\u0644\u0627\u062c \u0644\u0640 FIP\u060c \u062e\u0627\u0631\u062c \u0627\u0644\u0635\u064a\u0646 \u0623\u064a\u0636\u064b\u0627.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0627\u0644\u0648\u0636\u0639 \u0645\u0639 EIDD-1931 \u0648EIDD-2801\/Molnupiravir \u0648GS-441524 \u0648Remdesivir \u064a\u062b\u064a\u0631 \u0627\u0644\u062a\u0633\u0627\u0624\u0644 \u0639\u0646 \u0633\u0628\u0628 \u062a\u062d\u0648\u064a\u0644 \u0628\u0639\u0636 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0625\u0644\u0649 \u0639\u0642\u0627\u0642\u064a\u0631 \u0623\u0648\u0644\u064a\u0629 \u0644\u0644\u062a\u0633\u0648\u064a\u0642[17] . \u0648\u0628\u062d\u0633\u0628 \u0645\u0627 \u0648\u0631\u062f \u062a\u0645 \u062a\u0642\u062f\u064a\u0631 \u0639\u0642\u0627\u0631 \u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631 \u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a\u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u064a 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\u062a\u0645 \u0625\u0646\u0634\u0627\u0621 EIDD-2801 \u0644\u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0641\u0645\u0648\u064a \u0644\u0640 EIDD-1931\u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0623\u0634\u0627\u0631\u062a \u0625\u0644\u0649 \u0623\u0646 EIDD-1931 \u064a\u0645\u062a\u0635 \u062c\u064a\u062f\u064b\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u062f\u0648\u0646 \u0627\u0644\u0623\u0633\u062a\u0631\u0629 [6]. \u0638\u0644\u062a \u0627\u0644\u062f\u0648\u0627\u0641\u0639 \u0648\u0631\u0627\u0621 \u062a\u0633\u0648\u064a\u0642 \u0639\u0642\u0627\u0631 \u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631 \u0628\u062f\u0644\u0627 \u0645\u0646 GS-441524 \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0644\u0649 \u0627\u0644\u0628\u0634\u0631 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\u062a\u0643\u0648\u0646 \u0642\u0648\u0629 \u062d\u0642\u0648\u0642 \u0628\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0639 \u0648\u0637\u0648\u0644 \u0639\u0645\u0631 \u0628\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0639 \u0639\u0648\u0627\u0645\u0644 \u0623\u0643\u062b\u0631 \u0625\u0644\u062d\u0627\u062d\u064b\u0627 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0642\u0631\u0627\u0631 [16\u060c 17\u060c 19].<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0625\u062d\u062f\u0649 \u0627\u0644\u0645\u0634\u0627\u0643\u0644 \u0641\u064a \u0639\u0644\u0627\u062c FIP \u0641\u064a \u0627\u0644\u0642\u0637\u0637 \u0647\u064a \u062d\u0648\u0627\u062c\u0632 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u0639\u064a\u0646 \u0648\u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0635\u0628\u062d \u0630\u0627\u062a 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[20].  <strong>GC376\u060c \u0623\u062d\u062f \u0623\u0642\u0648\u0649 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0636\u062f \u0641\u064a\u0631\u0648\u0633 FIP \u0641\u064a \u0627\u0644\u062b\u0642\u0627\u0641\u0629<\/strong>[17] <strong>\u060c \u063a\u064a\u0631 \u0641\u0639\u0627\u0644 \u0636\u062f FIP \u0627\u0644\u0639\u064a\u0646\u064a \u0648\u0627\u0644\u0639\u0635\u0628\u064a<\/strong> \u0628\u0633\u0628\u0628 \u0639\u062f\u0645 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0627 \u064a\u0643\u0641\u064a \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u0648\u0627\u0642\u0639 \u062d\u062a\u0649 \u0639\u0646\u062f \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062c\u0631\u0639\u0629 \u0639\u062f\u0629 \u0645\u0631\u0627\u062a  [14]. \u0644\u062d\u0633\u0646 \u0627\u0644\u062d\u0638\u060c \u064a\u0628\u062f\u0648 \u0623\u0646 EIDD-1931 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0635\u0644 \u0625\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0641\u0639\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u062f\u0645\u0627\u063a \u0643\u0645\u0627 \u0623\u0634\u0627\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0627\u0644\u062e\u064a\u0648\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0639\u062f\u0648\u0649 VEEV [3]. \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0647\u064a \u0645\u0634\u0643\u0644\u0629 \u0623\u062e\u0631\u0649 \u062a\u0638\u0647\u0631 \u0627\u0644\u0622\u0646 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u062a\u064a \u064a\u062a\u0645 \u0639\u0644\u0627\u062c\u0647\u0627 \u0628\u0640 GS-441524\u060c \u0648\u062e\u0627\u0635\u0629 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0644\u0640 FIP. \u0625\u0646 \u062f\u0648\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0637\u0648\u064a\u0644\u0629 \u0648\u0635\u0639\u0648\u0628\u0629 \u0648\u0635\u0648\u0644 \u0643\u0645\u064a\u0629 \u0643\u0627\u0641\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a \u062a\u062f\u0639\u0645 \u062a\u0637\u0648\u0631 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0625\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0633\u0627\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0642\u0635\u064a\u0631 \u0648\u0627\u0644\u0637\u0648\u064a\u0644 \u0644\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u0631\u0634\u062d \u0639\u0644\u0649 \u0627\u0644\u0634\u062e\u0635 \u0623\u0648 \u0627\u0644\u062d\u064a\u0648\u0627\u0646 \u0627\u0644\u0630\u064a \u064a\u062a\u0645 \u0627\u062e\u062a\u0628\u0627\u0631\u0647 \u0644\u0647 \u0623\u0647\u0645\u064a\u0629 \u0642\u0635\u0648\u0649. GS-441524 \u0644\u0647 \u0633\u0645\u064a\u0629 \u0623\u0642\u0644 \u0645\u0646 GC376 \u0648EIDD-1931 \u0648EIDD-2801 \u0641\u064a \u0645\u0632\u0627\u0631\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627[15] . \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u062b <i>\u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a<\/i> \u0647\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u0623\u0647\u0645\u064a\u0629. <strong>\u064a\u0639\u062f GC376 \u0645\u0646 \u0628\u064a\u0646 \u0623\u0643\u062b\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629<\/strong>[15] <strong>\u0648\u0644\u0643\u0646\u0647 \u064a\u0624\u062e\u0631 \u0638\u0647\u0648\u0631 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u0639\u0646\u062f 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\u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0639\u062f\u0645 \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0639\u0645\u0644 \u0643\u0627\u0641\u064d \u0628\u0639\u062f\u060c \u064a\u0628\u062f\u0648 \u0623\u0646\u0647 \u0644\u0646 \u062a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u0645\u0642\u0627\u0648\u0645\u0629 \u0645\u062a\u0642\u0627\u0637\u0639\u0629 \u0628\u064a\u0646 GS-441524 \u0648Molnupiravir \u0648\u0644\u0643\u0646\u0647\u0627 \u0641\u0639\u0627\u0644\u0629 \u0645\u062b\u0644 GS-441524 \u0641\u064a \u0639\u0628\u0648\u0631 \u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a [3]. \u0647\u0630\u0647 \u0627\u0644\u0623\u0634\u064a\u0627\u0621 \u0645\u0646 \u0634\u0623\u0646\u0647\u0627 \u0623\u0646 \u062a\u062c\u0639\u0644 Molnupiravir (\u0623\u0648 5-hyroxycytidine) \u0625\u0636\u0627\u0641\u0629 \u0645\u0647\u0645\u0629 \u0644\u0639\u0644\u0627\u062c FIP \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a.<\/p>\n<p class=\"p2\">\u0643\u0645\u0627 \u0643\u0627\u0646 \u0645\u062a\u0648\u0642\u0639\u064b\u0627\u060c \u062a\u0645 \u0645\u0624\u062e\u0631\u064b\u0627 \u0627\u062e\u062a\u0628\u0627\u0631 Molnupiravir \u0639\u0644\u0649 \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0640 FIP \u0645\u0646 \u0642\u0628\u0644 \u0628\u0627\u0626\u0639 \u0635\u064a\u0646\u064a \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0644\u0640 GS-441524\u060c \u0648\u062a\u0645 \u0646\u0634\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0639\u0644\u0649 \u0645\u0648\u0642\u0639 FIP Warriors CZ\/SK.[26] . \u062a\u0623\u0644\u0641\u062a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u064a\u062f\u0627\u0646\u064a\u0629 \u0645\u0646 286 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\u0623\u064a\u0636\u064b\u0627 \u062d\u0633\u0627\u0628 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u0645\u0642\u062f\u0631\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0644\u0640 Molnupiravir \u0641\u064a \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0640 FIP \u0645\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0639\u0646 \u0639\u0644\u0627\u062c Covid-19. \u064a\u062a\u0645 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0644\u062c\u0648\u0646 \u0645\u0646 \u0645\u0631\u0636 \u0643\u0648\u0641\u064a\u062f-19 200 \u0645\u0644\u063a \u0645\u0646 \u0645\u0648\u0644\u0646\u0648\u0628\u064a\u0631\u0627\u0641\u064a\u0631 PO q12h \u0644\u0645\u062f\u0629 5 \u0623\u064a\u0627\u0645. \u0645\u0646 \u0627\u0644\u0648\u0627\u0636\u062d \u0623\u0646\u0647 \u062a\u0645 \u062d\u0633\u0627\u0628 \u0647\u0630\u0647 \u0627\u0644\u062c\u0631\u0639\u0629 \u0645\u0646 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0631\u0643\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0627\u0644\u0623\u0634\u062e\u0627\u0635\u060c \u0648\u0625\u0630\u0627 \u0643\u0627\u0646 \u0648\u0632\u0646 \u0627\u0644\u0634\u062e\u0635 \u0627\u0644\u0639\u0627\u062f\u064a 60-80 \u0643\u062c\u0645 (70 \u0643\u062c\u0645)\u060c \u0641\u0625\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062b\u0628\u0637\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0647\u064a ~ 3.0 \u0645\u062c\u0645\/\u0643\u062c\u0645 PO \u0643\u0644 12 \u0633\u0627\u0639\u0629. \u064a\u0645\u062a\u0644\u0643 \u0627\u0644\u0642\u0637 \u0645\u0639\u062f\u0644 \u0623\u064a\u0636 \u0623\u0633\u0627\u0633\u064a 1.5 \u0645\u0631\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0625\u0646\u0633\u0627\u0646\u060c \u0648\u0628\u0627\u0641\u062a\u0631\u0627\u0636 \u0623\u0646 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0645\u062a\u0633\u0627\u0648\u064d \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0648\u0627\u0644\u0642\u0637\u0637\u060c \u0641\u0625\u0646 \u0627\u0644\u062d\u062f \u0627\u0644\u0623\u062f\u0646\u0649 \u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0642\u0637\u0637 \u0628\u0647\u0630\u0627 \u0627\u0644\u062d\u0633\u0627\u0628 \u0633\u064a\u0643\u0648\u0646 4.5 \u0645\u0644\u062c\u0645\/\u0643\u062c\u0645 PO \u0643\u0644 12 \u0633\u0627\u0639\u0629. \u0639\u0644\u0649 \u0627\u0641\u062a\u0631\u0627\u0636 \u0623\u0646 Molnupiravir \u064a\u0639\u0628\u0631 \u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u0639\u064a\u0646 \u0648\u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u062f\u0645\u0627\u063a \u0628\u0643\u0641\u0627\u0621\u0629 \u0645\u062a\u0633\u0627\u0648\u064a\u0629 \u0645\u0639 GS-441524  [3,18]\u060c \u0633\u062a\u062a\u0645 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062c\u0631\u0639\u0629 ~ 1.5 \u0648 ~ 2.0 \u0645\u0631\u0629 \u0644\u0644\u0633\u0645\u0627\u062d \u0628\u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0642 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0641\u064a \u0627\u0644\u062e\u0644\u0637 \u0627\u0644\u0645\u0627\u0626\u064a \u0648\u0627\u0644\u0633\u0627\u0626\u0644 \u0627\u0644\u0646\u062e\u0627\u0639\u064a \u0644\u0644\u0642\u0637\u0637 \u0630\u0627\u062a \u0627\u0644\u0639\u064a\u0646 (~ 8 \u0645\u062c\u0645 \/ \u0643\u062c\u0645 PO\u060c Q12 \u0633\u0627\u0639\u0629) \u0623\u0648 FIP \u0627\u0644\u0639\u0635\u0628\u064a\u0629 (~ 10 \u0645\u062c\u0645 \/ \u0643\u062c\u0645 PO\u060c Q12 \u0633\u0627\u0639\u0629) ). \u0633\u062a\u0643\u0648\u0646 \u0645\u062f\u0629 \u0627\u0644\u0639\u0644\u0627\u062c 10-12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0648\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0645\u0637\u0627\u0628\u0642\u0629 \u0644\u0640 GS-441524 [14\u060c 20]. \u0648\u062a\u0633\u062a\u0646\u062f \u0647\u0630\u0647 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u0625\u0644\u0649 \u0627\u0641\u062a\u0631\u0627\u0636\u0627\u062a \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0648\u0633\u062a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062e\u0628\u0631\u0629 \u0645\u0639 Molnupiravir \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u062c\u0627\u0644. \u0645\u0646 \u0627\u0644\u0645\u0634\u0643\u0648\u0643 \u0641\u064a\u0647 \u0623\u0646 \u064a\u0643\u0648\u0646 Molnupiravir \u0623\u0643\u062b\u0631 \u0623\u0645\u0627\u0646\u064b\u0627 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u0645\u0646 GS-441524 \u0644\u0639\u0644\u0627\u062c FIP\u060c \u0648\u0644\u0643\u0646 \u0642\u062f \u064a\u0643\u0648\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u062b\u0627\u0644\u062b \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0645\u0641\u064a\u062f\u064b\u0627 \u0644\u0644\u063a\u0627\u064a\u0629 \u0641\u064a \u0645\u0646\u0639 \u0645\u0642\u0627\u0648\u0645\u0629 GS-441524 (\u0643\u0645\u0632\u064a\u062c \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0630\u0627\u062a \u0623\u0646\u0645\u0627\u0637 \u0645\u0642\u0627\u0648\u0645\u0629 \u0645\u062e\u062a\u0644\u0641\u0629) \u0623\u0648 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u0639\u062f \u062a\u0633\u062a\u062c\u064a\u0628 \u062c\u064a\u062f\u064b\u0627 \u0644\u0640 GS-441524. \u0627\u0644\u0645\u062c\u0647\u0648\u0644 \u0627\u0644\u0643\u0628\u064a\u0631 \u0647\u0648 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0645\u0648\u0644\u0646\u0648\u0628\u064a\u0631\u0627\u0641\u064a\u0631 \u0633\u064a\u0643\u0648\u0646 \u062e\u0627\u0644\u064a\u064b\u0627 \u0645\u0646 \u0627\u0644\u0633\u0645\u064a\u0627\u062a \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649\u060c \u062d\u064a\u062b \u0623\u0646 \u0627\u0644\u0639\u0646\u0635\u0631 \u0627\u0644\u0646\u0634\u0637\u060c N4-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0633\u064a\u062a\u064a\u062f\u064a\u0646\u060c \u0647\u0648 \u0645\u0637\u0641\u0631\u0629 \u0642\u0648\u064a\u0629 \u0644\u0644\u063a\u0627\u064a\u0629[21] \u0648\u0648\u0642\u062a \u0639\u0644\u0627\u062c FIP \u0623\u0637\u0648\u0644 \u0628\u0643\u062b\u064a\u0631 \u0645\u0646 \u0639\u0644\u0627\u062c Covid-19 \u0648\u0641\u0631\u0635 \u062d\u062f\u0648\u062b \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0623\u0643\u0628\u0631.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p3\">\u0645\u0646 \u0627\u0644\u0645\u0624\u0633\u0641 \u0623\u0646 EIDD-1931 (N4-hydroxycytidine)\u060c \u0627\u0644\u0639\u0646\u0635\u0631 \u0627\u0644\u0646\u0634\u0637 \u0641\u064a Molnupiravir\u060c \u0644\u0645 \u064a\u062d\u0638 \u0628\u0627\u0647\u062a\u0645\u0627\u0645 \u0623\u0643\u0628\u0631 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0642\u0637\u0637 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 FIP \u0645\u0646 Molnupiravir. \u0625\u0646 EIDD-1931 \u0623\u0643\u062b\u0631 \u062a\u062b\u0628\u064a\u0637\u064b\u0627 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0628\u0623\u0631\u0628\u0639 \u0645\u0631\u0627\u062a \u0645\u0646 \u0645\u0648\u0644\u0646\u0648\u0628\u064a\u0631\u0627\u0641\u064a\u0631 (EC50 0.09 \u0645\u0642\u0627\u0628\u0644 0.4 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631) \u0648\u0646\u0633\u0628\u0629 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0623\u0642\u0644 \u0625\u0644\u0649 \u062d\u062f \u0645\u0627 (2.3% \u0645\u0642\u0627\u0628\u0644 3.8% \u0639\u0646\u062f 100 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631)\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.[15] . \u064a\u062a\u0645 \u0623\u064a\u0636\u064b\u0627 \u0627\u0645\u062a\u0635\u0627\u0635 N4-hydroxycytidine \u0628\u0643\u0641\u0627\u0621\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 [3]\u060c \u0648\u0647\u0648 \u0623\u0645\u0631 \u062a\u0645 \u0627\u0644\u062a\u0642\u0644\u064a\u0644 \u0645\u0646 \u0623\u0647\u0645\u064a\u062a\u0647 \u0641\u064a \u062a\u0637\u0648\u064a\u0631 EIDD-2801 (Molnupiravir). <span class=\"s5\">\u0647\u0630\u0627 \u0627\u0644\u0633\u064a\u0646\u0627\u0631\u064a\u0648 \u0645\u0637\u0627\u0628\u0642 \u0644\u0633\u064a\u0646\u0627\u0631\u064a\u0648 GS-441524 \u0648Remdesivir\u060c \u062d\u064a\u062b \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0623\u062e\u064a\u0631 \u0644\u0644\u062a\u0633\u0648\u064a\u0642 \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u0623\u0648\u0644 \u0643\u0627\u0646 \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0631\u0634\u062d \u0627\u0644\u0623\u0641\u0636\u0644.<\/span>[17] <span class=\"s5\">.<span class=\"Apple-converted-space\"> <\/span><\/span> <\/p>\n<p class=\"p2\"><b>\u0645\u0631\u0627\u062c\u0639<span class=\"Apple-converted-space\"> <\/span><\/b><\/p>\n<p class=\"p2\">[1] \u0628\u064a\u0646\u062a\u0631 \u062c\u064a \u0622\u0631\u060c \u0646\u0627\u062a\u0634\u0648\u0633 \u0625\u0645 \u062c\u064a\u060c \u0643\u0648\u0647\u064a\u0646 \u0623\u0648\u060c \u0647\u0648\u0644\u0645\u0627\u0646 \u062f\u0628\u0644\u064a\u0648\u060c \u0628\u064a\u0646\u062a\u0631 \u062f\u0628\u0644\u064a\u0648 \u0628\u064a. \u062a\u0637\u0648\u064a\u0631 \u0639\u0627\u0645\u0644 \u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0645\u0628\u0627\u0634\u0631 \u0627\u0644\u0645\u0641\u0639\u0648\u0644 \u0648\u0645\u062a\u0627\u062d \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0641\u064a \u0627\u0644\u062c\u0627\u0626\u062d\u0629: \u062a\u0637\u0648\u0631 \u0645\u0648\u0644\u0646\u0648\u0628\u064a\u0631\u0627\u0641\u064a\u0631 \u0643\u0639\u0644\u0627\u062c \u0645\u062d\u062a\u0645\u0644 \u0644\u0643\u0648\u0641\u064a\u062f-19 [\u0646\u064f\u0634\u0631 \u0639\u0644\u0649 \u0627\u0644\u0625\u0646\u062a\u0631\u0646\u062a \u0642\u0628\u0644 \u0627\u0644\u0637\u0628\u0627\u0639\u0629\u060c 18 \u064a\u0648\u0646\u064a\u0648 2021]. <i>\u0627\u0644\u0639\u0645\u0644\u0629 \u0627\u0644\u0631\u0623\u064a Virol<\/i> . 2021;50:17-22. \u062f\u0648\u0649:10.1016\/j.coviro.2021.06.003<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[2] \u0647\u0627\u0644\u0641\u0648\u0631\u062f \u0628. \u0645\u0636\u0627\u062f \u0641\u064a\u0631\u0648\u0633\u064a \u0646\u0627\u0634\u0626 \u064a\u0633\u062a\u0647\u062f\u0641 \u0643\u0648\u0641\u064a\u062f-19. \u0645\u0648\u0636\u0648\u0639\u0627\u062a c&amp;en. 2020. https:\/\/cen.acs.org\/pharmaceuticals\/drug-development\/emerging-antiviral-takes-aim-COVID-19\/98\/web\/2020\/05.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[3] \u0627\u0644\u0631\u0633\u0627\u0645 \u062c\u064a \u0622\u0631\u060c \u0631\u064a\u062a\u0634\u0627\u0631\u062f \u0623. \u0628\u0648\u064a\u0646\u062f \u0622\u0631 \u0625\u064a\u0647\u060c \u0628\u0644\u0648\u0645\u0644\u064a\u0646\u063a \u062c\u064a \u0622\u0631 \u0648\u0622\u062e\u0631\u0648\u0646. \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0648\u0642\u0627\u0626\u064a \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0644\u062a\u0646\u0627\u0638\u0631\u064a\u0629 \u0631\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u0633\u064a\u062f \u0627\u0644\u0646\u0634\u0637\u0629 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0644\u0639\u062f\u0648\u0649 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062f\u0645\u0627\u063a \u0627\u0644\u062e\u064a\u0644\u064a \u0627\u0644\u0641\u0646\u0632\u0648\u064a\u0644\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0623\u0646\u0641. \u0627\u0644\u062f\u0642\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a. 2019, 171:104597<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[4] Costantini, VP, Whitaker, T., Barclay, L., Lee, D., McBrayer, TR, Schinazi, RF, Vinje,J., 2012. \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0644\u0646\u0638\u0627\u0626\u0631\u0647\u0627 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u0632\u064a\u062f\u064a\u0629 \u0636\u062f \u0627\u0644\u0646\u0648\u0631\u0648\u0641\u064a\u0631\u0648\u0633. \u0628\u0631\u0627\u0645\u062c \u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a. Ther.17 (6)\u060c 981-991. https:\/\/doi.org\/10.3851\/imp2229.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[5] Ehteshami, M., Tao, S., Zandi, K., Hsiao, HM, Jiang, Y., Hammond, E., Amblard, F., Russell, OO, Merits, A., Schinazi, RF, 2017. \u062a\u0648\u0635\u064a\u0641 \u0628\u064a\u062a\u0627-\u062f\u0646 (4)-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0633\u064a\u062a\u064a\u062f\u064a\u0646 \u0643\u0645\u062b\u0628\u0637 \u062c\u062f\u064a\u062f \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0634\u064a\u0643\u0648\u0646\u063a\u0648\u0646\u064a\u0627. \u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a. \u0648\u0643\u0644\u0627\u0621 \u0643\u064a\u0645\u0648\u062b\u0631. 61 (4) \u0647\u064002395-02316. https:\/\/doi.org\/10.1128\/aac.02395-16.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[6] \u0633\u062a\u0648\u064a\u0641\u0631\u060c \u0625\u0644 \u062c\u064a\u060c \u0648\u064a\u062a\u0627\u0643\u0631\u060c \u062a\u064a\u060c \u0645\u0627\u0643\u0628\u0631\u0627\u064a\u0631\u060c \u062a\u064a \u0622\u0631\u060c \u0647\u064a\u0631\u0646\u0627\u0646\u062f\u064a\u0632-\u0633\u0627\u0646\u062a\u064a\u0627\u063a\u0648\u060c \u0628\u064a \u0622\u064a\u060c \u0644\u0648\u0633\u062a\u064a\u0627\u060c \u0625\u0633\u060c \u062b\u0627\u0631\u0646\u064a\u0634\u060c \u0628\u064a \u0625\u0645\u060c \u0631\u0627\u0645\u064a\u0634\u060c \u0625\u0645\u060c \u062a\u0634\u0648\u060c \u0633\u064a \u0643\u064a\u0647\u060c \u062c\u0648\u0631\u062f\u0627\u0646\u060c \u0622\u0631.\u060c \u0634\u064a\u060c \u062c\u064a\u0647\u060c \u0631\u0627\u0634\u0627\u0643\u0648\u0646\u062f\u0627\u060c \u0625\u0633\u060c \u0648\u0627\u062a\u0627\u0646\u0627\u0628\u064a\u060c \u0643\u0627\u060c \u0623\u0648\u062a\u0648\u060c \u0625\u0645 \u062c\u064a\u060c \u0634\u064a\u0646\u0627\u0632\u064a\u060c \u0622\u0631 \u0625\u0641\u060c 2003. \u0646\u0638\u064a\u0631 \u0627\u0644\u0631\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u0633\u064a\u062f \u0627\u0644\u0630\u064a \u064a\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0625\u0633\u0647\u0627\u0644 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0627\u0644\u0628\u0642\u0631\u064a \u0648\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u0627\u0644\u0648\u0628\u0627\u0626\u064a \u0641\u064a \u0627\u0644\u062b\u0642\u0627\u0641\u0629. \u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a. \u0648\u0643\u0644\u0627\u0621 \u0643\u064a\u0645\u0648\u062b\u0631. 47 (1)\u060c 244-254.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[7] \u064a\u0648\u0646 \u062c.\u060c \u062a\u0648\u062a\u0633 \u0625\u0645\u060c \u0644\u064a \u0625\u0633\u060c \u0644\u064a \u0645\u064a\u060c \u0648\u0622\u062e\u0631\u0648\u0646\u060c 2018. \u0627\u0644\u0631\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u0633\u064a\u062f \u0648\u0627\u0633\u0639 \u0627\u0644\u0637\u064a\u0641 \u0641\u0639\u0627\u0644 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645<span class=\"Apple-converted-space\"> <\/span>\u0645\u062b\u0628\u0637 \u062a\u0645\u062b\u064a\u0644\u064a \u0644\u0644\u0623\u0646\u0641\u0644\u0648\u0646\u0632\u0627 \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u0644\u0648\u064a\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629. \u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a. \u0648\u0643\u0644\u0627\u0621 \u0643\u064a\u0645\u0648\u062b\u0631. 2018\u060c 62 (8):https:\/\/doi.org\/10.1128\/aac.00766-18 6<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[8]. Urakova N\u060c Kuznetsova V\u060c Crossman DK\u060c Sokratian A\u060c Guthrie DB\u060c Kolykhalov AA\u060c et al. \u03b2-d-N4-Hydroxycytidine \u0647\u0648 \u0645\u0631\u0643\u0628 \u0642\u0648\u064a \u0645\u0636\u0627\u062f \u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0623\u0644\u0641\u0627 \u0648\u0627\u0644\u0630\u064a \u064a\u062d\u0641\u0632 \u0645\u0633\u062a\u0648\u0649 \u0639\u0627\u0644\u064d \u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a. \u062c\u064a \u0641\u064a\u0631\u0648\u0644. 2018, 92:e01965\u2013e01917. \u062f\u0648\u0649: 10.1128\/JVI.01965-17.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[9] Pyrc, K., Bosch, BJ, Berkhout, B., Jebbink, MF, Dijkman, R., Rottier, P., van der Hoek,L., 2006. \u062a\u062b\u0628\u064a\u0637 \u0639\u062f\u0648\u0649 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0628\u0634\u0631\u064a NL63 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0645\u0646 \u062f\u0648\u0631\u0629 \u0627\u0644\u0646\u0633\u062e. \u0645\u0636\u0627\u062f \u0644\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a. \u0648\u0643\u0644\u0627\u0621 \u0643\u064a\u0645\u0648\u062b\u0631. 2006\u060c 50(6):2000-2008. https:\/\/doi.org\/10.1128\/aac.01598-05.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[10]. Whitfill T. \u0623\u0635\u0628\u062d \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u062f\u064a\u062f \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0644\u0640 Covid-19 \u0645\u0645\u0643\u0646\u064b\u0627 \u0628\u0641\u0636\u0644 \u0627\u0644\u0627\u0628\u062a\u0643\u0627\u0631 \u0627\u0644\u0630\u064a \u062a\u0645\u0648\u0644\u0647 \u0627\u0644\u062d\u0643\u0648\u0645\u0629. \u0627\u0644\u0642\u0627\u0646\u0648\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a+. https:\/\/www.statnews.com\/2021\/10\/05\/government-funding-backed-molnupiravir-possible-new-covid-19-treatment\/.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[11]  Painter\u060c GR\u060c Guthrie\u060c DB\u060c Bluemling\u060c G.\u060c Natchus\u060c MG N4-Hydroxycytidine \u0648\u0627\u0644\u0645\u0634\u062a\u0642\u0627\u062a \u0648\u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629. \u0637\u0644\u0628 \u0628\u0631\u0627\u0621\u0629 \u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0639 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629\u060c 2016\u060c 2016\/106050 A1.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[12]  \u0628\u064a\u0627\u0646 \u0635\u062d\u0641\u064a \u0644\u0634\u0631\u0643\u0629 \u0645\u064a\u0631\u0643\u060c 1 \u0623\u0643\u062a\u0648\u0628\u0631 2021. https:\/\/www.merck.com\/news\/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat\/.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[13]  \u0628\u064a\u062f\u0631\u0633\u0646 \u0646\u0648\u0631\u062b \u0643\u0627\u0631\u0648\u0644\u0627\u064a\u0646\u0627\u060c \u0643\u064a\u0645 \u0648\u0627\u064a\u060c \u0644\u064a\u0648 \u062d\u060c \u062c\u0627\u0644\u0627\u0633\u064a\u062a\u064a \u0643\u0627\u0646\u0643\u0627\u0646\u0627\u0645\u0627\u0644\u0627\u062c \u0625\u064a\u0647 \u0633\u064a\u060c \u0625\u064a\u0643\u0633\u062a\u0631\u0627\u0646\u062f \u062c\u060c \u062c\u0631\u0648\u062a\u0627\u0633 WC\u060c \u0628\u0627\u0646\u0627\u0634 \u0625\u0645\u060c \u0645\u064a\u062f\u0648\u0632 \u062c\u064a \u0625\u0645\u060c \u062a\u0634\u0627\u0646\u063a \u0643\u0648. \u0641\u0639\u0627\u0644\u064a\u0629 \u0645\u062b\u0628\u0637 \u0627\u0644\u0623\u0646\u0632\u064a\u0645 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a 3C \u0641\u064a \u0639\u0644\u0627\u062c \u0623\u0634\u0643\u0627\u0644 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0635\u0641\u0627\u0642 \u0627\u0644\u0645\u0639\u062f\u064a \u0644\u062f\u0649 \u0627\u0644\u0642\u0637\u0637. J \u0627\u0644\u0642\u0637\u0637 \u0645\u064a\u062f \u0633\u0648\u0631\u062c. 2018, 20(4):378-392.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[14]  Pedersen NC\u060c Perron M\u060c Bannasch M\u060c Montgomery E\u060c Murakami E\u060c Liepnieks M\u060c Liu H. \u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u062a\u0646\u0627\u0638\u0631\u064a\u0629 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u0633\u064a\u062f\u064a\u0629 GS-441524 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0635\u0641\u0627\u0642 \u0627\u0644\u0645\u0639\u062f\u064a \u0627\u0644\u0642\u0637\u0637\u064a \u0627\u0644\u0630\u064a \u064a\u062d\u062f\u062b \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a. J \u0627\u0644\u0642\u0637\u0637 \u0645\u064a\u062f \u0633\u0648\u0631\u062c. 2019, 21(4):271-281.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[15]  Cook SE\u060c Vogel H and D. Castillo D. \u0646\u0647\u062c \u0639\u0642\u0644\u0627\u0646\u064a \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0636\u062f \u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0642\u0637\u0637. 2021. \u0628\u064a\u0648\u0631\u0643\u0633\u064a\u0641 2020.07.09.195016; \u062f\u0648\u064a: https:\/\/doi.org\/10.1101\/2020.07.09.195016<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[16]  Zhang S. \u062f\u0648\u0627\u0621 \u0643\u0648\u0641\u064a\u062f-19 \u0627\u0644\u0630\u064a \u062d\u0638\u064a \u0628\u062a\u063a\u0637\u064a\u0629 \u0625\u0639\u0644\u0627\u0645\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 \u064a\u0643\u0627\u062f \u064a\u0643\u0648\u0646 \u0645\u0637\u0627\u0628\u0642\u064b\u0627 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0642\u0637\u0637 \u0641\u064a \u0627\u0644\u0633\u0648\u0642 \u0627\u0644\u0633\u0648\u062f\u0627\u0621. 8 \u0645\u0627\u064a\u0648 2020<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0634\u062a\u0631\u0633\u062a\u0648\u0643 \/ \u0627\u0644\u0645\u062d\u064a\u0637 \u0627\u0644\u0623\u0637\u0644\u0633\u064a\u060c https:\/\/www.theatlantic.com\/science\/archive\/2020\/05\/remdesivir-cats\/611341\/.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[17]  \u064a\u0627\u0646 \u0641\u064a \u0633\u064a\u060c \u0645\u0648\u0644\u0631 \u0641\u0644\u0648\u0631\u064a\u062f\u0627. \u0645\u0632\u0627\u064a\u0627 \u0639\u0642\u0627\u0631 Nucleoside GS-441524 \u0627\u0644\u0623\u0635\u0644\u064a \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0639\u0642\u0627\u0631 Remdesivir \u0644\u0639\u0644\u0627\u062c \u0643\u0648\u0641\u064a\u062f-19. \u0631\u0633\u0627\u0626\u0644 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u0637\u0628\u064a\u0629 ACS. 2020\u060c <i>11<\/i> (7):1361-1366 DOI: 10.1021\/acsmedchemlett.0c00316<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[18]  \u0645\u064a\u0631\u0641\u064a BG, \u0628\u064a\u0631\u0648\u0646 M, \u0647 \u0645\u0648\u0631\u0627\u0643\u0627\u0645\u064a, \u0643 \u0628\u0627\u0648\u0631, \u0628\u0627\u0631\u0643 Y, \u062c \u0625\u064a\u0643\u0633\u062a\u0631\u0627\u0646\u062f, \u0645 \u0644\u064a\u0628\u0646\u064a\u0643\u0633, \u0628\u064a\u062f\u0631\u0633\u0646 \u0646\u0648\u0631\u062b \u0643\u0627\u0631\u0648\u0644\u0627\u064a\u0646\u0627. \u064a\u062b\u0628\u0637 \u0646\u0638\u064a\u0631 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u0632\u064a\u062f GS-441524 \u0628\u0642\u0648\u0629 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0635\u0641\u0627\u0642 \u0627\u0644\u0645\u0639\u062f\u064a (FIP) \u0644\u062f\u0649 \u0627\u0644\u0642\u0637\u0637 \u0641\u064a \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0648\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u062f\u0648\u0649 \u0627\u0644\u0642\u0637\u0637 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629. 2018, 219:226-233.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[19]. \u0627\u0644\u0623\u062d\u0644\u0627\u0645 \u0627\u0644\u0645\u0634\u062a\u0631\u0643\u0629. \u0645\u0648\u0627\u0637\u0646 \u0639\u0627\u0645. \u0628\u064a\u0627\u0646 \u0635\u062d\u0641\u064a\u060c 4 \u0623\u063a\u0633\u0637\u0633\/\u0622\u0628 2020\u060c https:\/\/www.commondreams.org\/newswire\/2020\/08\/04\/public-citizen-scientists-gilead-and-federal-scientists-have-neglected 7<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[20]  \u062f\u064a\u0643\u0646\u0633\u0648\u0646 \u0628\u064a \u062c\u064a. \u0639\u062f\u0648\u0649 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0631\u0643\u0632\u064a: \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0641\u064a \u0632\u0645\u0646 \u0643\u0648\u0641\u064a\u062f-19. \u0623\u0645\u0627\u0645. \u062f\u0643\u062a\u0648\u0631 \u0628\u064a\u0637\u0631\u064a. \u0627\u0644\u062e\u064a\u0627\u0644 \u0627\u0644\u0639\u0644\u0645\u064a. 2020\u060c 23: https:\/\/doi.org\/10.3389\/fvets.2020.584673<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[21]  Zhou S, Hill CS, Sarkar S, et al., \u03b2-d- <i>N<\/i> <span class=\"s6\">4<\/span> -hydroxycytidine \u064a\u0645\u0646\u0639 \u0627\u0644\u0633\u0627\u0631\u0633-CoV-2 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u062a\u0644\u0629 \u0648\u0644\u0643\u0646\u0647 \u0623\u064a\u0636\u064b\u0627 \u0645\u0633\u0628\u0628 \u0644\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062b\u062f\u064a\u064a\u0627\u062a. J \u0625\u0635\u0627\u0628\u0629 \u062f\u064a\u0633. 2021\u060c 224: 415\u2013419\u060c https:\/\/doi.org\/10.1093\/infdis\/jiab247.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[22]  Cohen J, Piller C. \u062a\u0639\u0631\u0636 \u0631\u0633\u0627\u0626\u0644 \u0627\u0644\u0628\u0631\u064a\u062f \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0646\u0638\u0631 \u0641\u064a \u0627\u062a\u0647\u0627\u0645\u0627\u062a \u0627\u0644\u0645\u0628\u0644\u063a\u064a\u0646 \u0639\u0646 \u0627\u0644\u0645\u062e\u0627\u0644\u0641\u0627\u062a \u0628\u0627\u0644\u0645\u062d\u0633\u0648\u0628\u064a\u0629 \u0648\u0631\u0627\u0621 \u062f\u0648\u0627\u0621 \u0645\u062d\u062a\u0645\u0644 \u0644\u0643\u0648\u0641\u064a\u062f-19. ScienceInsider-\u0627\u0644\u0635\u062d\u0629. 2020\u060c https:\/\/www.science.org\/news\/2020\/05\/emails-offer-look-whistleblower-charges-cronyism-behind-potential-covid-19-drug.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[23]  \u0623\u063a\u0648\u0633\u062a\u064a\u0646\u064a \u0645\u0644\u060c \u0623\u0646\u062f\u0631\u064a\u0633 \u0625\u0644\u060c \u0633\u064a\u0645\u0632 \u0625\u064a\u0647 \u0633\u064a\u060c \u0648\u0622\u062e\u0631\u0648\u0646. \u062a\u062a\u0648\u0633\u0637 \u0642\u0627\u0628\u0644\u064a\u0629 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0644\u0644\u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a (GS-5734) \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0648\u062a\u0635\u062d\u064a\u062d \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u0637\u0628\u0639\u064a\u0629 \u0625\u0643\u0633\u0648\u0631\u064a\u0628\u0648\u0646\u0648\u0643\u0644\u064a\u0627\u0632. <i>\u0645\u0628\u064a\u0648<\/i> 2018\u061b 9. DOI: 10.1128\/mBio.00221-18.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[24]  Szemiel AM\u060c Merits A\u060c Orton RJ\u060c \u064a\u0634\u064a\u0631 \u0627\u0644\u0627\u062e\u062a\u064a\u0627\u0631 <i>\u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a<\/i> \u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0639\u0642\u0627\u0631 Remdesivir \u0625\u0644\u0649 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u062a\u0646\u0628\u0624 \u0627\u0644\u062a\u0637\u0648\u0631\u064a \u0644\u0640 SARS-CoV-2. \u0645\u0633\u0627\u0631 \u0628\u0644\u0648\u0633\u060c 2021\u060chttps:\/\/doi.org\/10.1371\/journal.ppat.1009929 .<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[25]  \u0645\u0627\u0631\u062a\u064a\u0646\u0648\u062a \u0625\u0645\u060c \u062c\u0627\u0631\u064a \u0623\u060c \u0641\u0627\u0641\u064a \u0643\u0631\u064a\u0645\u0631 \u0625\u0633\u060c \u0648\u0622\u062e\u0631\u0648\u0646\u060c \u0637\u0641\u0631\u0629 \u0628\u0648\u0644\u064a\u0645\u064a\u0631\u064a\u0632 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0646\u0627\u0634\u0626\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a (RNA) \u0641\u064a \u0645\u0631\u064a\u0636 \u064a\u0639\u0627\u0646\u064a \u0645\u0646 \u0646\u0642\u0635 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0642\u0627\u0631 \u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631 \u0648\u064a\u0639\u0627\u0646\u064a \u0645\u0646 \u0645\u0631\u0636 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0645\u0637\u0648\u0644 2019\u060c <i>\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0639\u062f\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/i> \u060c 2020\u061b\u060c ciaa1474\u060c https:\/ \/doi.org\/10.1093\/cid\/ciaa1474<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[26]  FIP Warriors CZ\/SK <span class=\"s7\">&#8211;<\/span> EIDD-2801 (\u0645\u0648\u0644\u0646\u0648\u0628\u064a\u0631\u0627\u0641\u064a\u0631)<span class=\"Apple-converted-space\"> <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u064a\u0641\u0643\u0631 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0623\u0635\u062d\u0627\u0628 \u0627\u0644\u0642\u0637\u0637 \u0645\u0646 FIP \u0641\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 Molnupiravir \u0648GS441524 \u0639\u0646\u062f\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0627\u0644\u0623\u0645\u0631 \u0628\u0645\u0639\u0627\u0644\u062c\u0629 \u0642\u0637\u062a\u0647\u0645. \u0627\u0644\u062d\u0642\u064a\u0642\u0629 \u0647\u064a \u0623\u0646 \u0643\u0644\u0627 \u0627\u0644\u062e\u064a\u0627\u0631\u064a\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u064a\u0646 \u0641\u0639\u0627\u0644\u0627\u0646 \u0641\u064a \u0639\u0644\u0627\u062c FIP \u0648\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0639\u0642\u0627\u0631 Molnupiravir \u0634\u062f\u064a\u062f \u0627\u0644\u0633\u0645\u064a\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647 \u062f\u0648\u0627\u0621 \u062e\u0637\u064a\u0631 \u0644\u0644\u063a\u0627\u064a\u0629 \u0644\u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0645\u0646 \u0628\u064a\u0646\u0647\u0627\u060c \u062e\u0627\u0635\u0629 \u0639\u0646\u062f\u0645\u0627 \u062a\u062d\u062a\u0627\u062c \u0625\u0644\u0649 \u0639\u0644\u0627\u062c \u0642\u0637\u062a\u0643 \u0644\u0645\u062f\u0629 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627\u060c \u0648\u0644\u0627 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16937,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_glsr_average":0,"_glsr_ranking":0,"_glsr_reviews":0,"footnotes":""},"categories":[643],"tags":[],"_links":{"self":[{"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/pages\/17173"}],"collection":[{"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/comments?post=17173"}],"version-history":[{"count":0,"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/pages\/17173\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/media\/16937"}],"wp:attachment":[{"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/media?parent=17173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/categories?post=17173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fipmed.co\/ar\/wp-json\/wp\/v2\/tags?post=17173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}