{"id":22365,"date":"2022-12-02T08:05:01","date_gmt":"2022-12-02T08:05:01","guid":{"rendered":"https:\/\/fipmed.co\/lecba-kocek-s-cipem-lekarsky-pokrok-pro-kocky-s-cipem-zachranuje-kocky\/"},"modified":"2025-02-25T07:09:28","modified_gmt":"2025-02-25T07:09:28","slug":"lecba-fip-kocek-s-cipem-lekarsky-pokrok-pro-kocky-s-cipem-zachranuje-kocky","status":"publish","type":"page","link":"https:\/\/fipmed.co\/cs\/lecba-fip-kocek-s-cipem-lekarsky-pokrok-pro-kocky-s-cipem-zachranuje-kocky\/","title":{"rendered":"L\u00e9\u010dba FIP ko\u010dek: Pokrok v l\u00e9\u010db\u011b FIP zachra\u0148uje ko\u010dky"},"content":{"rendered":"

Pro ko\u010dky je ji\u017e k dispozici osv\u011bd\u010den\u00e1 l\u00e9\u010dba FIP ko\u010dek.
\nZ d\u016fvodu nedostatku finan\u010dn\u00ed motivace v\u0161ak v sou\u010dasn\u00e9 dob\u011b neexistuje \u017e\u00e1dn\u00fd ofici\u00e1ln\u011b schv\u00e1len\u00fd l\u00e9k na FIP u ko\u010dek<\/a>.
\nPodp\u016frn\u00e1 l\u00e9\u010dba m\u016f\u017ee zm\u00edrnit nep\u0159\u00edjemn\u00e9 pocity, ale nezv\u00fd\u0161\u00ed m\u00edru p\u0159e\u017eit\u00ed, nap\u0159\u00edklad protiz\u00e1n\u011btliv\u00e9 l\u00e9ky a dren\u00e1\u017e tekutiny z hrudn\u00edku a b\u0159icha.
\nVzhledem k rychl\u00e9 a vysok\u00e9 \u00famrtnosti byla v minulosti nejlep\u0161\u00ed volbou eutanazie, ale dnes lze l\u00e9\u010dbu zajistit s vysokou m\u00edrou \u00fasp\u011b\u0161nosti.
\nV sou\u010dasn\u00e9 dob\u011b se zkoum\u00e1 n\u011bkolik zkou\u0161en\u00fdch l\u00e9k\u016f, v\u010detn\u011b GS441524, GC376, CL-Pro a Remdesivir.
\nTyto l\u00e9ky nejsou v sou\u010dasn\u00e9 dob\u011b leg\u00e1ln\u011b dostupn\u00e9 pro klinick\u00e9 pou\u017eit\u00ed u ko\u010dek.<\/p>\n

<\/h2>\n

ANTIVIRALIKA (inhibitory prote\u00e1z, inhibitory polymer\u00e1z, nukleosidov\u00e1 analoga<\/strong> ) Jedin\u00e9 l\u00e9\u010debn\u00e9 p\u0159\u00edpravky, kter\u00e9 nyn\u00ed d\u00e1vaj\u00ed ko\u010dk\u00e1m s FIP nad\u011bji<\/a>, jsou GS441524, co\u017e je nukleosidov\u00fd analog, a GC376, inhibitor prote\u00e1z.
\nGS441524 z\u016fst\u00e1v\u00e1 nejlep\u0161\u00ed volbou pro l\u00e9\u010dbu FIP d\u00edky ni\u017e\u0161\u00edmu po\u010dtu recidiv ve srovn\u00e1n\u00ed s GC376.
\nVe srovn\u00e1n\u00ed s p\u0159\u00edpravkem Remdesivir je tak\u00e9 rychleji \u00fa\u010dinn\u00fd.
\nRemdesivir je ve skute\u010dnosti prekurzorem GS441524, tak\u017ee k tomu, aby mohl p\u016fsobit, je zapot\u0159eb\u00ed dal\u0161\u00ed krok, aby se Remdesivir p\u0159em\u011bnil na GS441524. \u00a0GS-441524<\/strong> Byly poskytnuty d\u016fkazy, \u017ee tento l\u00e9k funguje dob\u0159e v mnoha situac\u00edch.
\nJeho z\u00edsk\u00e1n\u00ed bylo obt\u00ed\u017en\u00e9.
\nRemdesivir, jak ji\u017e bylo uvedeno, je protil\u00e1tka nebo prol\u00e9\u010divo, kter\u00e9 t\u011blo n\u00e1sledn\u011b p\u0159em\u011bn\u00ed na GS-441524.
\nPod\u00e1n\u00ed l\u00e9ku ve form\u011b protid\u016f nebo prol\u00e9\u010div napom\u00e1h\u00e1 jeho z\u00edsk\u00e1n\u00ed do bun\u011bk imunitn\u00edho syst\u00e9mu, kter\u00e9 obsahuj\u00ed imunosupresivn\u00ed koronaviry.
\nP\u0159i testov\u00e1n\u00ed n\u011bkter\u00fdch l\u00e9k\u016f u ko\u010dek byl GS-441524 pod\u00e1v\u00e1n ve sv\u00e9 p\u016fvodn\u00ed form\u011b, p\u0159i\u010dem\u017e nebyla pozorov\u00e1na \u017e\u00e1dn\u00e1 \u00fasp\u011b\u0161n\u00e1 m\u00edra vyl\u00e9\u010den\u00ed FIP. \u00a0 GS441524 je v sou\u010dasnosti st\u00e1le nejlep\u0161\u00ed mo\u017enost\u00ed l\u00e9\u010dby.
\nVzhledem k vysok\u00e9 cen\u011b a nedostupnosti tohoto l\u00e9ku by v\u0161ak majitel\u00e9 ko\u010dek m\u011bli v\u00edce tla\u010dit na to, aby jejich ko\u010dka onemocn\u011bn\u00ed v\u016fbec nechytila. \u00a0GC376<\/strong> GC376 lze pova\u017eovat za \u0161irokospektr\u00e9 antivirov\u00e9 l\u00e9\u010divo, kter\u00e9 inhibuje Mpro<\/sup> n\u011bkolika vir\u016f, v\u010detn\u011b koronavir\u016f, jako je FCoV, virus prase\u010d\u00edho epidemick\u00e9ho pr\u016fjmu (PEDV), SARS-CoV, MERS-CoV, SARS-CoV-2, koronavirus fretek a nork\u016f.
\nGC376 je prol\u00e9\u010divo GC373, dal\u0161\u00edho inhibitoru prote\u00e1z na b\u00e1zi dipeptid\u016f.
\nL\u00e9\u010dba FIP u ko\u010dek pomoc\u00ed GC376 byla spojena s ne\u017e\u00e1douc\u00edmi \u00fa\u010dinky, jako je p\u0159echodn\u00e9 p\u00edch\u00e1n\u00ed v m\u00edstech vpichu, podko\u017en\u00ed fibr\u00f3za, vypad\u00e1v\u00e1n\u00ed srsti a abnorm\u00e1ln\u00ed pro\u0159ez\u00e1v\u00e1n\u00ed st\u00e1l\u00fdch zub\u016f u mlad\u00fdch ko\u010dek[4]<\/span>.
\nProto je t\u0159eba prov\u00e9st dal\u0161\u00ed studie, kter\u00e9 by vyhodnotily mo\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky spojen\u00e9 s pou\u017eit\u00edm GC376 na zv\u00ed\u0159ec\u00edch modelech p\u0159ed jeho pou\u017eit\u00edm v klinick\u00fdch studi\u00edch.
\nGC376 zabra\u0148uje replikaci viru FCoV jin\u00fdm mechanismem.
\nM\u00edra relapsu u ko\u010dek l\u00e9\u010den\u00fdch GC376 je v\u0161ak v\u00fdrazn\u011b vy\u0161\u0161\u00ed ne\u017e u GS441524.
\nKde GC376 zaz\u00e1\u0159\u00ed, je situace, kdy se u ko\u010dek vyvinula rezistence v\u016f\u010di GS441524, zejm\u00e9na v p\u0159\u00edpadech relapsu.
\nPak je vhodn\u00e9 pou\u017e\u00edt m\u00edsto n\u011bj GC376.
\nExistuj\u00ed tak\u00e9 v\u00fdzkumn\u00e9 studie, kter\u00e9 ukazuj\u00ed, \u017ee kombinace GS441524 a GC376 p\u0159in\u00e1\u0161\u00ed lep\u0161\u00ed v\u00fdsledky a tak\u00e9 umo\u017enila krat\u0161\u00ed dobu l\u00e9\u010dby 6 t\u00fddn\u016f m\u00edsto obvykl\u00fdch 12 t\u00fddn\u016f.<\/p>\n

Ko\u010di\u010d\u00ed interferon<\/b><\/p>\n

Interferon je l\u00e1tka, kterou t\u011blo p\u0159irozen\u011b vytv\u00e1\u0159\u00ed v reakci na virovou infekci.
\nVeterin\u00e1rn\u00ed l\u00e9ka\u0159i maj\u00ed k dispozici dva druhy interferon\u016f: ko\u010di\u010d\u00ed interferon omega (Virbagen Omega,\u00ae vyr\u00e1b\u011bn\u00fd spole\u010dnost\u00ed Virbac ve Francii) a lidsk\u00fd interferon alfa, kter\u00fd se vyr\u00e1b\u00ed pod n\u011bkolika obchodn\u00edmi n\u00e1zvy.
\nJe vhodn\u011bj\u0161\u00ed pou\u017e\u00edvat ko\u010di\u010d\u00ed interferon, proto\u017ee interferony jsou druhov\u011b specifick\u00e9: nejl\u00e9pe funguj\u00ed u druhu, ze kter\u00e9ho poch\u00e1zej\u00ed.
\nInterferon-omega je injekce prod\u00e1van\u00e1 pro ko\u010dky s FIP.
\nMal\u00e1 ran\u00e1 studie uk\u00e1zala slibn\u00e9 v\u00fdsledky, a tak se na kr\u00e1tkou dobu stal sou\u010d\u00e1st\u00ed standardn\u00ed l\u00e9\u010dby.
\nByla to jedna z prvn\u00edch dostupn\u00fdch l\u00e9\u010debn\u00fdch metod pro FIP<\/a>, nicm\u00e9n\u011b \u00fasp\u011b\u0161nost byla n\u00edzk\u00e1.
\nV\u011bt\u0161\u00ed dvojit\u011b zaslepen\u00e1 placebem kontrolovan\u00e1 studie nezjistila \u017e\u00e1dn\u00fd p\u0159\u00ednos interferonu.
\nT\u00edm m\u011bla v\u011bc skon\u010dit, ale l\u00e9k je st\u00e1le k dispozici a lid\u00e9 st\u00e1le prosazuj\u00ed d\u0159\u00edv\u011bj\u0161\u00ed pr\u00e1ci bez odkazu na tu pozd\u011bj\u0161\u00ed.<\/p>\n

KORTIKOSTEROIDY (POUZE PRO PALLIALITIVE)<\/strong><\/p>\n

V po\u010d\u00e1te\u010dn\u00edm st\u00e1diu onemocn\u011bn\u00ed m\u016f\u017ee b\u00fdt nutn\u00e1 podp\u016frn\u00e1 (symptomatick\u00e1) l\u00e9\u010dba, kter\u00e1 udr\u017e\u00ed ko\u010dky na\u017eivu dostate\u010dn\u011b dlouho, aby mohly za\u010d\u00edt p\u016fsobit antivirotika.
\nMezi l\u00e9ky jsou \u010dasto zahrnuty protiz\u00e1n\u011btliv\u00e9 l\u00e9ky (kortikosteroidy, NSAIDS).
\nJe vhodn\u011bj\u0161\u00ed vyhnout se nadm\u011brn\u00e9mu pou\u017e\u00edv\u00e1n\u00ed t\u011bchto l\u00e9k\u016f, leda\u017ee by se jednalo o kr\u00e1tkodob\u00e9 pod\u00e1v\u00e1n\u00ed a pouze v p\u0159\u00edpad\u011b, \u017ee pro to existuj\u00ed p\u00e1dn\u00e9 d\u016fvody, zejm\u00e9na u extr\u00e9mn\u011b \u0161patn\u011b se c\u00edt\u00edc\u00edch ko\u010dek v prvn\u00edch dnech. <\/span><\/p>\n

Hlavn\u00edm c\u00edlem l\u00e9\u010dby FIP je zabr\u00e1nit replikaci viru v makrof\u00e1z\u00edch, co\u017e okam\u017eit\u011b zastav\u00ed tvorbu r\u016fzn\u00fdch z\u00e1n\u011btliv\u00fdch a imunosupresivn\u00edch cytokin\u016f, kter\u00e9 vyvol\u00e1vaj\u00ed p\u0159\u00edznaky FIP.
\nZat\u00edmco n\u011bkter\u00e9 l\u00e9ky, jako jsou kortikosteroidy (prednisolon) a NSAID (meloxikam), mohou z\u00e1n\u011btliv\u00e9 cytokiny sni\u017eovat, GS-441524 tyto \u0161kodliv\u00e9 cytokiny zcela blokuje.
\nB\u011bhem 24-48 hodin vyvol\u00e1 p\u0159\u00edpravek FipMed v\u00fdrazn\u00e9 zlep\u0161en\u00ed teploty, aktivity, hladu a dal\u0161\u00edch p\u0159\u00edznak\u016f.
\nToto zlep\u0161en\u00ed bude v\u00fdrazn\u011b v\u011bt\u0161\u00ed, ne\u017e m\u016f\u017ee poskytnout jak\u00fdkoli jin\u00fd l\u00e9k.
\nV d\u016fsledku toho, pokud neexistuje z\u00e1va\u017en\u00fd d\u016fvod pro pokra\u010dov\u00e1n\u00ed v u\u017e\u00edv\u00e1n\u00ed jin\u00fdch l\u00e9k\u016f, m\u011bly by b\u00fdt vysazeny, jakmile dojde ke znateln\u00e9mu a trval\u00e9mu zlep\u0161en\u00ed p\u0159\u00edznak\u016f FIP<\/a>. <\/span><\/p>\n

Krom\u011b maskov\u00e1n\u00ed p\u0159\u00edznak\u016f souvisej\u00edc\u00edch s FIP mohou steroidy naru\u0161ovat distribuci p\u0159\u00edpravku GS-441524 p\u0159es hematoencefalickou bari\u00e9ru.
\nN\u011bkolik studi\u00ed prok\u00e1zalo, \u017ee steroidy mohou sn\u00ed\u017eit prostupnost p\u0159es hematoencefalickou bari\u00e9ru.
\nU ko\u010dek m\u016f\u017ee sn\u00ed\u017een\u00e1 propustnost sn\u00ed\u017eit \u00fa\u010dinnost GS-441524 a zv\u00fd\u0161it pravd\u011bpodobnost recidivy. <\/span><\/p>\n

 <\/p>\n

GS 441524<\/a> Bezpe\u010dnost jako l\u00e9\u010dba FIP<\/b><\/span><\/p>\n

Bylo prok\u00e1z\u00e1no, \u017ee GS-441524 je bezpe\u010dnou a \u00fa\u010dinnou mo\u017enost\u00ed l\u00e9\u010dby.
\nTento l\u00e9k byl p\u016fvodn\u011b vyvinut jako antivirotikum pro lidi, ale od t\u00e9 doby byl znovu pou\u017eit pro ko\u010dky. <\/span><\/p>\n

\u010cetn\u00e9 studie prok\u00e1zaly, \u017ee l\u00e9k nezp\u016fsobuje v\u00fdznamn\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky nebo toxicitu, pokud je pod\u00e1v\u00e1n podle pokyn\u016f.<\/span><\/p>\n

U n\u011bkter\u00fdch ko\u010dek se mohou b\u011bhem l\u00e9\u010dby vyskytnout m\u00edrn\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, jako je nevolnost nebo letargie.
\nTyto p\u0159\u00edznaky obvykle rychle odezn\u00ed a nevy\u017eaduj\u00ed z\u00e1sah veterin\u00e1rn\u00edho l\u00e9ka\u0159e. <\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Pro ko\u010dky je ji\u017e k dispozici osv\u011bd\u010den\u00e1 l\u00e9\u010dba FIP ko\u010dek. Z d\u016fvodu nedostatku finan\u010dn\u00ed motivace v\u0161ak v sou\u010dasn\u00e9 dob\u011b neexistuje \u017e\u00e1dn\u00fd ofici\u00e1ln\u011b schv\u00e1len\u00fd l\u00e9k na FIP u ko\u010dek. Podp\u016frn\u00e1 l\u00e9\u010dba m\u016f\u017ee zm\u00edrnit nep\u0159\u00edjemn\u00e9 pocity, ale nezv\u00fd\u0161\u00ed m\u00edru p\u0159e\u017eit\u00ed, nap\u0159\u00edklad protiz\u00e1n\u011btliv\u00e9 l\u00e9ky a dren\u00e1\u017e tekutiny z hrudn\u00edku a b\u0159icha. Vzhledem k rychl\u00e9 a vysok\u00e9 \u00famrtnosti byla […]<\/p>\n","protected":false},"author":11,"featured_media":22368,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_glsr_average":0,"_glsr_ranking":0,"_glsr_reviews":0,"footnotes":""},"categories":[849],"tags":[850,895],"_links":{"self":[{"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/pages\/22365"}],"collection":[{"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/comments?post=22365"}],"version-history":[{"count":2,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/pages\/22365\/revisions"}],"predecessor-version":[{"id":29253,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/pages\/22365\/revisions\/29253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/media\/22368"}],"wp:attachment":[{"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/media?parent=22365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/categories?post=22365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fipmed.co\/cs\/wp-json\/wp\/v2\/tags?post=22365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}