{"id":22630,"date":"2024-03-28T04:32:29","date_gmt":"2024-03-28T04:32:29","guid":{"rendered":"https:\/\/fipmed.co\/molnupiravir-os-trito-antiiiko-pharmako-gia-ti-therapeia-tis-fip\/"},"modified":"2024-03-28T04:32:29","modified_gmt":"2024-03-28T04:32:29","slug":"molnupiravir-os-trito-antiiiko-pharmako-gia-ti-therapeia-tis-fip","status":"publish","type":"page","link":"https:\/\/fipmed.co\/el\/molnupiravir-os-trito-antiiiko-pharmako-gia-ti-therapeia-tis-fip\/","title":{"rendered":"Molnupiravir \u03c9\u03c2 \u03c4\u03c1\u03af\u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP"},"content":{"rendered":"<p class=\"p2\"><span class=\"s1\"><span class=\"Apple-converted-space\">\u03a0\u03bf\u03bb\u03bb\u03bf\u03af \u03b9\u03b4\u03b9\u03bf\u03ba\u03c4\u03ae\u03c4\u03b5\u03c2 \u03b3\u03ac\u03c4\u03b1\u03c2 \u03bc\u03b5 FIP \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf Molnupiravir \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf GS441524 \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b3\u03ac\u03c4\u03b1 \u03c4\u03bf\u03c5\u03c2.<br \/>\n\u0397 \u03b1\u03bb\u03ae\u03b8\u03b5\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf Molnupiravir \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c7\u03bf\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b5\u03c4\u03b5, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03c3\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03b3\u03ac\u03c4\u03b1 \u03c3\u03b1\u03c2 \u03b3\u03b9\u03b1 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03b8\u03b5\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1.    <\/span><\/span><\/p>\n<p class=\"p2\"><strong><span class=\"s1\"><span class=\"Apple-converted-space\">\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03b7 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 &#8220;\u03a4\u03bf molnupiravir \u03c9\u03c2 \u03c4\u03c1\u03af\u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP&#8221; \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Dr. <\/span><\/span><i>Niels C. Pedersen DVM, PhD<span class=\"Apple-converted-space\"> \u03c3\u03c4\u03bf <\/span><\/i><i>20 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5 2021<span class=\"Apple-converted-space\"> <\/span><\/i> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p2\">\u0397 <span class=\"s2\">\u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7, \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf-\u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c4\u03bf\u03c5 Molnupiravir, \u03b5\u03af\u03bd\u03b1\u03b9 <\/span>\u03ad\u03bd\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf (\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03b6\u03af\u03c4\u03b7\u03c2) \u03c0\u03bf\u03c5 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b1 \u03c4\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 1970 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03bb\u03b9\u03ac \u03a3\u03bf\u03b2\u03b9\u03b5\u03c4\u03b9\u03ba\u03ae \u0388\u03bd\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c0\u03bb\u03b1 [2].<br \/>\n\u0397 \u03bf\u03c0\u03bb\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b5\u03c5\u03bb\u03bf\u03b3\u03b9\u03ac \u03ae\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03bf\u03c2 \u03c6\u03cc\u03b2\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03c4\u03b7\u03c2 \u03b5\u03c5\u03bb\u03bf\u03b3\u03b9\u03ac\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03ba\u03bf\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03bb\u03ac \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03b9.<br \/>\n\u0397 \u03b5\u03c5\u03bb\u03bf\u03b3\u03b9\u03ac \u03b5\u03af\u03c7\u03b5 \u03b5\u03be\u03b1\u03bb\u03b5\u03b9\u03c6\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ba\u03cc\u03c3\u03bc\u03bf, \u03cc\u03bb\u03b1 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03b1 \u03b1\u03c0\u03bf\u03b8\u03ad\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03c7\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b5\u03af\u03c7\u03b5 \u03b1\u03c0\u03b1\u03b3\u03bf\u03c1\u03b5\u03c5\u03c4\u03b5\u03af.<br \/>\n\u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03a3\u03bf\u03b2\u03b9\u03b5\u03c4\u03b9\u03ba\u03ae \u0388\u03bd\u03c9\u03c3\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03b9\u03bf\u03cd\u03c2 RNA \u03c9\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c0\u03bb\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ac\u03bc\u03c5\u03bd\u03ac \u03c4\u03bf\u03c5\u03c2.<br \/>\n\u039f \u03b9\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03bf\u03bc\u03c5\u03b5\u03bb\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b9\u03c0\u03c0\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03c4\u03b7\u03c2 \u0392\u03b5\u03bd\u03b5\u03b6\u03bf\u03c5\u03ad\u03bb\u03b1\u03c2 (VEEV) \u03ae\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5\u03c2 \u03b9\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03c3\u03bf\u03b2\u03b1\u03c1\u03ac \u03c9\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c0\u03bb\u03b1 [3].<br \/>\n\u039f VEEV \u03bc\u03b5\u03c4\u03b1\u03b4\u03af\u03b4\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c3\u03b9\u03bc\u03c0\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03bf\u03c5\u03bd\u03bf\u03c5\u03c0\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c5\u03c8\u03b7\u03bb\u03cc \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc, \u03c0\u03bf\u03bd\u03bf\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03af\u03c4\u03b9\u03b4\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b1\u03bd\u03b1\u03c4\u03b7\u03c6\u03cc\u03c1\u03bf.<br \/>\n\u0392\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 VEEV, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03b1\u03bb\u03c6\u03b1\u03ca\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03bf Ebola, \u03bf chikungunya, \u03bf \u03b9\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03c1\u03af\u03c0\u03b7\u03c2, \u03bf \u03bd\u03bf\u03c1\u03bf\u03ca\u03cc\u03c2, \u03bf \u03b9\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2\u03bf\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd, \u03bf \u03b9\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 C \u03ba\u03b1\u03b9 \u03bf \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c5\u03c4\u03b9\u03b1\u03ba\u03cc\u03c2 \u03b9\u03cc\u03c2. [3-8].<br \/>\n\u0397 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7\u03c2<span class=\"s2\">\u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd <\/span>\u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03ba\u03bf\u03c1\u03bf\u03bd\u03b1\u03ca\u03cc NL63 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03c4\u03bf 2006 [9].<br \/>\n\u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b1\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b6\u03c9\u03b9\u03ba\u03ce\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03b1\u03ca\u03ce\u03bd [8].        <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0388\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b9\u03bf \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u0399\u03bd\u03c3\u03c4\u03b9\u03c4\u03bf\u03cd\u03c4\u03bf \u0391\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd Emory (EIDD) [1], \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 \u03ae\u03c4\u03b1\u03bd EIDD-1931.<br \/>\n\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03c9\u03bd \u03b1\u03bb\u03c6\u03b1\u03ca\u03ce\u03bd \u03c3\u03b5 \u03b9\u03b4\u03c1\u03cd\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf Emory \u03c0\u03b1\u03c1\u03b5\u03af\u03c7\u03b5 \u03b7 \u03ba\u03c5\u03b2\u03ad\u03c1\u03bd\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u0397\u03a0\u0391 \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf 2004, \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03c3\u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd [10].<br \/>\n\u0397 \u03a5\u03c0\u03b7\u03c1\u03b5\u03c3\u03af\u03b1 \u039c\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u0391\u03c0\u03b5\u03b9\u03bb\u03ce\u03bd \u0386\u03bc\u03c5\u03bd\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b5\u03af\u03c7\u03b5 \u03b8\u03b5\u03c3\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03c4\u03bf 2014 \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ae\u03c2 \u03ad\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 VEEV \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b1\u03bb\u03c6\u03b1\u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03ce\u03bd.<br \/>\n\u0397 &#8220;\u039d4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03b1\u03bd\u03c4\u03b9-\u03b9\u03b9\u03ba\u03ad\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2&#8221; \u03ba\u03b1\u03bb\u03cd\u03c6\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03b4\u03b9\u03c0\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03c5\u03c1\u03b5\u03c3\u03b9\u03c4\u03b5\u03c7\u03bd\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u0397\u03a0\u0391 2016\/106050 A1 \u03c4\u03bf 2016 [11].<br \/>\n\u03a0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03ae\u03c1\u03b8\u03b5 \u03c4\u03bf 2019 \u03b1\u03c0\u03cc \u03c4\u03bf \u0395\u03b8\u03bd\u03b9\u03ba\u03cc \u0399\u03bd\u03c3\u03c4\u03b9\u03c4\u03bf\u03cd\u03c4\u03bf \u0391\u03bb\u03bb\u03b5\u03c1\u03b3\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u039b\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b5\u03c4\u03b1\u03af\u03c1\u03bf\u03c5 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c3\u03c4\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03c0\u03c1\u03bf\u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c4\u03b7\u03c2 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7\u03c2 (EIDD-2801) \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b3\u03c1\u03af\u03c0\u03b7\u03c2 [10].<br \/>\n\u0397 \u03b4\u03b7\u03bb\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c7\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf EIDD-2801 \u03ae\u03c4\u03b1\u03bd \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03c5\u03b8\u03b5\u03af \u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b8\u03b1 \u03b5\u03c0\u03ad\u03c4\u03c1\u03b5\u03c0\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7 \u03bd\u03b1     <span class=\"s1\"><span class=\"Apple-converted-space\"> <\/span><\/span>\u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c7\u03ac\u03c0\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c9\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2.<br \/>\n\u03a4\u03bf 2019\/2020 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b3\u03c1\u03af\u03c0\u03b7 \u03c3\u03c4\u03bf\u03bd SARS-II CoV [2].<br \/>\n\u0397 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 EIDD-2801 \u03b4\u03cc\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b8\u03c5\u03b3\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 Emory \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 Ridgeway Biotherapeutics, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c4\u03b7 Merck \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03ac \u03ba\u03b1\u03b9 \u03b4\u03b1\u03c0\u03b1\u03bd\u03b7\u03c1\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA.<br \/>\n\u0397 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1 \u03ad\u03ba\u03b4\u03bf\u03c3\u03b7 \u03c4\u03bf\u03c5 EIDD-2081 \u03c0\u03bf\u03c5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03ad\u03c7\u03b5\u03b9 \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03c4\u03b5\u03af Molnupiravir.   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0397 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7<span class=\"s2\">, \u03c4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 Molnupiravir, <\/span>\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c9\u03c2 \u03c4\u03b1\u03c5\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae.<br \/>\n\u03a3\u03c4\u03b7 \u03bc\u03af\u03b1 \u03bc\u03bf\u03c1\u03c6\u03ae, \u03bc\u03b9\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7, \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c0\u03bb\u03cc \u03b4\u03b5\u03c3\u03bc\u03cc \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 \u03ac\u03bd\u03b8\u03c1\u03b1\u03ba\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 N-OH.<br \/>\n\u03a3\u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b9\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03c5\u03c1\u03b9\u03b4\u03af\u03bd\u03b7, \u03ad\u03c7\u03b5\u03b9 \u03bf\u03be\u03af\u03bc\u03b7 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03cc \u03b4\u03b5\u03c3\u03bc\u03cc \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 \u03ac\u03bd\u03b8\u03c1\u03b1\u03ba\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 N-OH.<br \/>\n\u03a0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7\u03c2, \u03b7 \u03b9\u03b9\u03ba\u03ae RNA-\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 RNA \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03b9 \u03c9\u03c2 \u03bf\u03c5\u03c1\u03b9\u03b4\u03af\u03bd\u03b7 \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03c3\u03ac\u03b3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7 \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03b3\u03bf\u03c5\u03b1\u03bd\u03bf\u03c3\u03af\u03bd\u03b7.<br \/>\n\u0397 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03af\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03b9\u03b9\u03ba\u03cc \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03cd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 [8].    <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0397 \u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 Molnupiravir \u03b1\u03c0\u03cc \u03c4\u03b7 Merck \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc \u03cc\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03c4\u03b1\u03c7\u03c5\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1.<br \/>\n\u03a3\u03b5 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b9\u03ba\u03ae \u03b4\u03ae\u03bb\u03c9\u03c3\u03b7, \u03b7 Merck \u03b4\u03ae\u03bb\u03c9\u03c3\u03b5 \u03c4\u03b1 \u03b5\u03be\u03ae\u03c2 [12] &#8211; &#8221; <i>\u0395\u03bd \u03b1\u03bd\u03b1\u03bc\u03bf\u03bd\u03ae \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd <\/i>2 <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\"><i>\u03b1\u03c0\u03cc \u03c4\u03b7 MOVe-OUT, \u03b7 Merck \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 Molnupiravir \u03bc\u03b5 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf. \u0397 Merck \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 10 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 2021, \u03b5\u03bd\u03ce \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf 2022. &#8230;&#8230;. . \u0397 Merck \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03c0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf Molnupiravir \u03c3\u03b5 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf, \u03b5\u03ac\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03ae \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af, \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c6\u03b1\u03c1\u03bc\u03cc\u03c3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bc\u03b1\u03ba\u03c9\u03c4\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c4\u03b9\u03bc\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03b5\u03b9\u03c3\u03bf\u03b4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1\u03c2 \u03a4\u03c1\u03ac\u03c0\u03b5\u03b6\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c7\u03c9\u03c1\u03ce\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03b9\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03bd\u03b4\u03b7\u03bc\u03af\u03b1. &#8230;&#8230; . \u03a3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7, \u03b7 Merck \u03b1\u03bd\u03b1\u03ba\u03bf\u03af\u03bd\u03c9\u03c3\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03c5\u03bc\u03ad\u03bd\u03c9\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03ac\u03c8\u03b5\u03b9 \u03bc\u03b7 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b5\u03c2 \u03b1\u03b4\u03b5\u03b9\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf Molnupiravir \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c4\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 Molnupiravir \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc 100 \u03c7\u03ce\u03c1\u03b5\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c3\u03b1\u03af\u03bf\u03c5 \u03b5\u03b9\u03c3\u03bf\u03b4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (LMIC) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03ae \u03ad\u03ba\u03c4\u03b1\u03ba\u03c4\u03b5\u03c2 \u03b5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2&#8221;.  <\/i>\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03af\u03b8\u03b1\u03bd\u03bf \u03b1\u03c5\u03c4\u03ae \u03b7 &#8220;\u03b3\u03b5\u03bd\u03bd\u03b1\u03b9\u03bf\u03b4\u03c9\u03c1\u03af\u03b1&#8221; \u03bd\u03b1 \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b6\u03ce\u03c9\u03bd.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1\u03c2 \u03c0\u03b1\u03bd\u03b4\u03b7\u03bc\u03af\u03b1\u03c2 Covid-19, \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03c4\u03b1\u03c7\u03ad\u03c9\u03c2 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b4\u03cd\u03bf \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac, \u03c4\u03bf Remdesivir, \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03bf \u03c1\u03b5\u03ba\u03cc\u03c1 \u03b3\u03b9\u03b1 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<br \/>\n\u03a4\u03bf molnupiravir \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c5\u03c0\u03cc \u03cc\u03c1\u03bf\u03c5\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ad\u03c4\u03bf\u03c5\u03c2 \u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4&#8217; \u03bf\u03af\u03ba\u03bf\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf [12].<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03bf\u03cd \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03ac\u03bb\u03bb\u03b7 \u03ba\u03bf\u03b9\u03bd\u03ae \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c5\u03c7\u03bd\u03ae \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b3\u03b1\u03c4\u03ce\u03bd, \u03c4\u03b7 \u03bb\u03bf\u03b9\u03bc\u03ce\u03b4\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03af\u03c4\u03b9\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bb\u03bf\u03c5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd (FIP).<br \/>\n\u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7\u03c2 (GC376) [13] \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf RNA \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 RNA (GS-441524) \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 Remdesivir [14].<br \/>\n\u0397 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 EIDD-1931 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 EIDD-2801 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd FIPV \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03b9\u03c3\u03c4\u03ce\u03bd [15].<br \/>\n\u0397 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7-50% (EC50) \u03b3\u03b9\u03b1 \u03c4\u03bf EIDD-1931 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 FIPV \u03b5\u03af\u03bd\u03b1\u03b9 0,09 uM, \u03c4\u03bf EIDD-2801 0,4 uM \u03ba\u03b1\u03b9 \u03c4\u03bf GS-441524 0,66 Um [15].     <strong>  \u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 100 uM \u03b5\u03af\u03bd\u03b1\u03b9 2,8, 3,8 \u03ba\u03b1\u03b9 0 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1.<br \/>\n\u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03bf\u03b9 EIDD-1931 \u03ba\u03b1\u03b9 -2801 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf GS-441524. <\/strong>  \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf EIDD-1931 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf EIDD-2801 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ac\u03c1\u03b9\u03c3\u03c4\u03bf\u03b9 \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u03a0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03c4\u03b1 EIDD-1931 \u03ba\u03b1\u03b9 EIDD-2801 \u03c5\u03c0\u03cc\u03c3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03b1\u03c0\u03af\u03b8\u03b1\u03bd\u03b7 \u03c4\u03b7 \u03bd\u03cc\u03bc\u03b9\u03bc\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b5\u03bd\u03ce\u03c3\u03b5\u03c9\u03bd \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b1.<br \/>\n\u03a4\u03bf GS-441524, \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03bf\u03c5 Remdesivir, \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03bf\u03c7\u03c5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 \u03b4\u03af\u03c0\u03bb\u03c9\u03bc\u03b1 \u03b5\u03c5\u03c1\u03b5\u03c3\u03b9\u03c4\u03b5\u03c7\u03bd\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Gilead Sciences, \u03b5\u03c1\u03b5\u03c5\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP \u03bb\u03af\u03b3\u03bf \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03bd\u03b4\u03b7\u03bc\u03af\u03b1\u03c2 Covid-19.<br \/>\n\u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03ae\u03c4\u03b1\u03bd \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 Remdesivir \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u0388\u03bc\u03c0\u03bf\u03bb\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c4\u03c9\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03ce\u03bd \u03c0\u03bf\u03c5 \u03bc\u03bf\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03bf\u03bd SARS \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd FIP [14].<br \/>\n\u03a0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03ad\u03b3\u03b9\u03bd\u03b1\u03bd \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03bf\u03bd\u03b5\u03c2 \u03c4\u03b7\u03c2 Gilead Science, \u03b7 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03b1\u03c1\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c4\u03b1 \u03b4\u03b9\u03ba\u03b1\u03b9\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b6\u03ce\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf GS-441524 \u03bc\u03cc\u03bb\u03b9\u03c2 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03c6\u03b1\u03bd\u03b5\u03c1\u03cc \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ae\u03c1\u03c7\u03b5 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03b3\u03bf\u03c1\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf Covid-19 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf [16].<br \/>\n\u03a0\u03b1\u03c1\u03bf\u03bc\u03bf\u03af\u03c9\u03c2, \u03bf\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03ad\u03c2 \u03bc\u03bf\u03c5 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 2-3 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd Emory, \u03c4\u03b7\u03bd Ridgeback Biotherapeutics \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ba\u03c4\u03b7\u03bd\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03b7\u03c2 Merck \u03bd\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf EIDD-1931 \u03ba\u03b1\u03b9 \u03c4\u03bf EIDD-2801 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd FIP \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03b5\u03af\u03c4\u03b5 \u03ad\u03bc\u03b5\u03b9\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03bf\u03c1\u03c1\u03af\u03c6\u03b8\u03b7\u03ba\u03b1\u03bd, \u03b1\u03bd\u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03bf\u03c5\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b7 Gilead \u03b1\u03c1\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03b4\u03b9\u03ba\u03b1\u03b9\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03b6\u03ce\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf GS-441524.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP \u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b5 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03bc\u03b9\u03b1 \u03bc\u03b7 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b3\u03bf\u03c1\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf GS-441524 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1.<br \/>\n\u0397 \u03af\u03b4\u03b9\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP \u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b5 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c4\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf Molnupiravir \u03c9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1.      <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0397 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 EIDD-1931 \u03ba\u03b1\u03b9 EIDD-2801\/Molnupiravir \u03ba\u03b1\u03b9 GS-441524 \u03ba\u03b1\u03b9 Remdesivir \u03b8\u03ad\u03c4\u03b5\u03b9 \u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b3\u03b9\u03b1\u03c4\u03af \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac [17].<br \/>\n\u03a4\u03bf Remdesivir \u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c3\u03c4\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af \u03b7 \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c4\u03bf GS-441524 \u03ba\u03b1\u03b9 \u03c4\u03bf Remdesivir \u03b5\u03af\u03c7\u03b1\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03b9\u03c3\u03c4\u03ce\u03bd [18].<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf Remdesivir \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03ac\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9, \u03c9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5, \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c5\u03c0\u03cc \u03cc\u03c1\u03bf\u03c5\u03c2 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7.<br \/>\n\u03a4\u03bf EIDD-2801 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 EIDD-1931, \u03c0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c4\u03bf EIDD-1931 \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bb\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03c3\u03c4\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 [6].<br \/>\n\u03a4\u03b1 \u03ba\u03af\u03bd\u03b7\u03c4\u03c1\u03b1 \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 Remdesivir \u03b1\u03bd\u03c4\u03af \u03c4\u03bf\u03c5 GS-441524 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bc\u03c6\u03b9\u03c3\u03b2\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c4\u03bf \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b5\u03c1\u03b5\u03af \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 [17].<br \/>\n\u0393\u03b9\u03b1\u03c4\u03af \u03c0\u03c1\u03bf\u03c4\u03ac\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf EIDD-2801, \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf EIDD-1931 \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c6\u03b8\u03b7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf, 4 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03ad\u03bd\u03b1 \u03c4\u03c1\u03af\u03c4\u03bf \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03bf\u03be\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf EIDD-2801 [15];<br \/>\n\u0397 \u03b9\u03c3\u03c7\u03cd\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03ba\u03b1\u03b9\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03c5\u03c1\u03b5\u03c3\u03b9\u03c4\u03b5\u03c7\u03bd\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b2\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c5\u03c1\u03b5\u03c3\u03b9\u03c4\u03b5\u03c7\u03bd\u03af\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 [16, 17, 19].      <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0388\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP \u03c3\u03c4\u03b9\u03c2 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c6\u03c1\u03b1\u03b3\u03bc\u03bf\u03af \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03c4\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b1 \u03bc\u03ac\u03c4\u03b9\u03b1 \u03ae\/\u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf [13, 14, 20].<br \/>\n\u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b1\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03be\u03b5\u03c0\u03b5\u03c1\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03c4\u03b7\u03c2 FIP \u03bc\u03b5 \u03c4\u03bf GS-441524 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03c5\u03b4\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03c5\u03b3\u03c1\u03cc \u03ba\u03b1\u03b9\/\u03ae \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf [20]. <strong>\u03a4\u03bf GC376, \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ac \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03c4\u03b7\u03c2 FIP \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 [17], \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 FIP<\/strong> \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1\u03c2 \u03bd\u03b1 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 [14].<br \/>\n\u0395\u03c5\u03c4\u03c5\u03c7\u03ce\u03c2, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf EIDD-1931 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf, \u03cc\u03c0\u03c9\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03b1\u03c0\u03cc VEEV [3].<br \/>\n\u0397 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 GS-441524, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2 FIP.<br \/>\n\u039f\u03b9 \u03bc\u03b1\u03ba\u03c1\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03b5\u03b9\u03c3\u03cc\u03b4\u03bf\u03c5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf.    <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u0397 \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03ae \u03b6\u03ce\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b1\u03c1\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2.<br \/>\n\u03a4\u03bf GS-441524 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 GC376, EIDD-1931 \u03ba\u03b1\u03b9 EIDD-2801 \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 [15].<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 <i>in v <\/i>ivo \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae. <strong>\u03a4\u03bf GC376 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03b1\u03ca\u03cc [15], \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b5\u03af \u03c4\u03b7\u03bd \u03bf\u03b4\u03bf\u03bd\u03c4\u03bf\u03c6\u03c5\u0390\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd \u03cc\u03c4\u03b1\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ac \u03b3\u03b1\u03c4\u03ac\u03ba\u03b9\u03b1 [13].<\/strong>   <strong>\u0394\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03bc\u03af\u03b1 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03c1\u03b9\u03ce\u03bd \u03b5\u03c4\u03ce\u03bd \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 GS-441524 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd in vitro \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 400 uM [18].<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03b1 EIDD-1931 \u03ba\u03b1\u03b9 EIDd-2801 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 100 uM <\/strong> [15].<br \/>\nTherefore, it is the ability of EIDD-1931 to create fatal mutations in RNA has been of greatest concern for some time [8, 21, 22].<br \/>\nThis has been a big reason why it has been slow to be applied to disease.<br \/>\nHowever, the current recommended treatment of Covid-19 with Molnupiravir is for only 5 days at the early stage of treatment [10].<br \/>\nHowever, the recommended treatment with GS-441524 for FIP is 12 weeks [14], allowing much greater time for toxicity to manifest itself.<br \/>\nTherefore, it will be important to carefully observe cats on EIDD-1931 or EIDD-2801 treatment for both short- and long-term effects.     <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">\u038c\u03bb\u03b1 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b9\u03b9\u03ba\u03cc \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1.<br \/>\n\u03a0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03c4\u03bf Remdesivir \u03ad\u03c7\u03b5\u03b9 \u03c6\u03b1\u03bd\u03b5\u03af \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf \u03c3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b9\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf HIV\/AIDS, \u03b7 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03b8\u03b5\u03af \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 [23-25].<br \/>\n\u0397 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf GS-441524 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd FIP \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae FIP, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03bd\u03b1 \u03b5\u03b9\u03c3\u03ad\u03bb\u03b8\u03b5\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf [13, 14, 20].<br \/>\n\u0397 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf GS-441524 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03b9 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP \u03c3\u03c5\u03c7\u03bd\u03ac \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ae \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf, \u03b5\u03bd\u03ce \u03c4\u03bf Remdesivir (\u03ba\u03b1\u03b9 \u03c4\u03bf Molnupiravir) \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03b9\u03c1\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03bf\u03c5 Covid-19 [16].<br \/>\n\u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 HIV\/AIDS \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03bf\u03ba\u03c4\u03ad\u03b9\u03bb \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<br \/>\n\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b8\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1, \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03cc\u03c8\u03b5\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<br \/>\n\u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b5\u03c0\u03b9\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd.<br \/>\n\u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c4\u03bf GC376 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7\u03c2 [13], \u03b5\u03bd\u03ce \u03c4\u03bf GS-441524 \u03b4\u03c1\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf RNA RNA \u03c1\u03b5\u03c0\u03bb\u03b9\u03ba\u03ac\u03c3\u03b7 [18].<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf GC376 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03ac\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03ba\u03b1\u03bb\u03ac \u03b4\u03b9\u03b1\u03bc\u03ad\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd \u03c6\u03c1\u03b1\u03b3\u03bc\u03bf\u03cd.<br \/>\n\u0391\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b3\u03af\u03bd\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b8\u03b1 \u03c5\u03c0\u03ac\u03c1\u03be\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03c5\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 GS-441524 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 Molnupiravir \u03b1\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5 \u03c4\u03bf GS-441524 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03c1\u03b1\u03b3\u03bc\u03bf\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2-\u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5 [3].<br \/>\n\u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b8\u03b1 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03c3\u03b1\u03bd \u03c4\u03bf Molnupiravir (\u03ae \u03c4\u03b7\u03bd 5-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7) \u03bc\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP.          <\/p>\n<p class=\"p2\">\u038c\u03c0\u03c9\u03c2 \u03b1\u03bd\u03b1\u03bc\u03b5\u03bd\u03cc\u03c4\u03b1\u03bd, \u03c4\u03bf Molnupiravir \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03ad\u03bd\u03b1\u03bd \u039a\u03b9\u03bd\u03ad\u03b6\u03bf \u03c0\u03c9\u03bb\u03b7\u03c4\u03ae \u03c4\u03bf\u03c5 GS-441524 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03c4\u03b1\u03c1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03bf\u03bd \u03b9\u03c3\u03c4\u03cc\u03c4\u03bf\u03c0\u03bf FIP Warriors CZ\/SK [26].<br \/>\n\u0397 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c0\u03b5\u03b4\u03af\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b5 286 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 FIP \u03c0\u03bf\u03c5 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03bf\u03b9\u03ba\u03af\u03b4\u03b9\u03c9\u03bd \u03b6\u03ce\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391, \u03c4\u03bf \u0397\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u0392\u03b1\u03c3\u03af\u03bb\u03b5\u03b9\u03bf, \u03c4\u03b7\u03bd \u0399\u03c4\u03b1\u03bb\u03af\u03b1, \u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1, \u03c4\u03b7 \u0393\u03b1\u03bb\u03bb\u03af\u03b1, \u03c4\u03b7\u03bd \u0399\u03b1\u03c0\u03c9\u03bd\u03af\u03b1, \u03c4\u03b7 \u03a1\u03bf\u03c5\u03bc\u03b1\u03bd\u03af\u03b1, \u03c4\u03b7\u03bd \u03a4\u03bf\u03c5\u03c1\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1.<br \/>\n\u0394\u03b5\u03bd \u03c3\u03b7\u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1\u03c2 \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd 286 \u03b3\u03b1\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03af\u03c7\u03b1\u03bd \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03b5\u03c0\u03c4\u03ac \u03b3\u03b1\u03c4\u03ce\u03bd \u03bc\u03b5 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae (n=2) \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae (n=5) FIP.<br \/>\n\u0395\u03af\u03ba\u03bf\u03c3\u03b9 \u03bf\u03ba\u03c4\u03ce \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03c4\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 4-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 258 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<br \/>\n\u038c\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03b9\u03bd\u03b1\u03bd \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 3-5 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1, \u03c0\u03b5\u03c1\u03af\u03bf\u03b4\u03bf \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ad\u03c2 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03c4\u03b7\u03ba\u03b1\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ce\u03c2.    <span class=\"s3\">.<br \/>\nT <\/span><span class=\"s4\">\u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03b4\u03b9\u03ac\u03c3\u03b5\u03b9\u03c3\u03c4\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 Molnupiravir \u03b3\u03b9\u03b1 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 FIP.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b5\u03bb\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c0\u03b5\u03b4\u03af\u03bf\u03c5 \u03b8\u03b1 \u03b3\u03c1\u03b1\u03c6\u03c4\u03b5\u03af \u03c3\u03b5 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c7\u03b5\u03b9\u03c1\u03bf\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5, \u03b8\u03b1 \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03bf\u03bc\u03bf\u03c4\u03af\u03bc\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03c4\u03b5\u03af.<br \/>\n\u03a0\u03b1\u03c1&#8217; \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03c0\u03c9\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b9\u03b4\u03b9\u03bf\u03ba\u03c4\u03ae\u03c4\u03b5\u03c2 \u03b3\u03b1\u03c4\u03ce\u03bd \u03bc\u03b5 FIP.<br \/>\n\u03a4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03ad\u03bd\u03b1\u03c2 \u03ac\u03bb\u03bb\u03bf\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c2 \u03c0\u03c9\u03bb\u03b7\u03c4\u03ae\u03c2 \u03c4\u03bf\u03c5 GS-441524 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf Molnupiravir \u03b3\u03b9\u03b1 \u03c4\u03b7 FIP, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP.   <span class=\"Apple-converted-space\"> <\/span><\/span><\/p>\n<p class=\"p3\">\u0394\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03c4\u03b5\u03af \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf Molnupiravir \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03ad\u03bd\u03b1\u03c2 \u03c0\u03c9\u03bb\u03b7\u03c4\u03ae\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03ac\u03c3\u03c7\u03b5\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03b9\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03bf\u03bb\u03bd\u03bf\u03c5\u03c0\u03b1\u03c1\u03b9\u03b2\u03af\u03c1\u03b7 \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 FIP \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03c6\u03b7\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c6\u03c5\u03bb\u03bb\u03ac\u03b4\u03b9\u03bf \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 Hero-2081 [26].<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 Molnupiravir \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 &#8220;\u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 50 mg&#8221; \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 (q12h \u03ae q24h;).<br \/>\n\u0395\u03c5\u03c4\u03c5\u03c7\u03ce\u03c2, \u03bc\u03b9\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf Molnupiravir \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 in vitro \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c4\u03c9\u03bd EIDD-1931 \u03ba\u03b1\u03b9 EIDD-2801 [15] \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03b5\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 GS-441524 [14,18].<br \/>\n\u03a4\u03bf molnupiravir (EIDD-2801) \u03ad\u03c7\u03b5\u03b9 EC50 0,4 uM\/ul \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 FIPV \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1, \u03b5\u03bd\u03ce \u03c4\u03bf EC50 \u03c4\u03bf\u03c5 GS-441524 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 1,0 uM\/ul [18].<br \/>\n\u039a\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 40-50%, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 (SC) \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf Molnupiravir \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf \u03ae\u03bc\u03b9\u03c3\u03c5 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b5\u03ba\u03ba\u03af\u03bd\u03b7\u03c3\u03b7\u03c2 4 mg\/kg SC q24h \u03b3\u03b9\u03b1 \u03c4\u03bf GS-441524 [14], \u03ae 2 mg\/kg SC q24h.<br \/>\n\u0397 \u03b4\u03cc\u03c3\u03b7 <i>per-os <\/i>(PO) \u03b8\u03b1 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03b6\u03cc\u03c4\u03b1\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03c5\u03c0\u03cc\u03c8\u03b7 \u03b7 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b7 4 mg\/kg PO q24h.<br \/>\n\u039c\u03b9\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf Molnupiravir \u03c3\u03b5 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 FIP \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03c4\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Covid-19.<br \/>\n\u03a3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Covid-19 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 200 mg Molnupiravir PO q12h \u03b3\u03b9\u03b1 5 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2.<br \/>\n\u0391\u03c5\u03c4\u03ae \u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c0\u03c1\u03bf\u03c6\u03b1\u03bd\u03ce\u03c2 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03bf\u03c5 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03ac\u03bd \u03ad\u03bd\u03b1\u03c2 \u03bc\u03ad\u03c3\u03bf\u03c2 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03c2 \u03b6\u03c5\u03b3\u03af\u03b6\u03b5\u03b9 60-80 kg (70 kg), \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 ~3,0 mg\/kg PO q12h.<br \/>\n\u039c\u03b9\u03b1 \u03b3\u03ac\u03c4\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03cc 1,5 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03ad\u03c4\u03bf\u03bd\u03c4\u03b1\u03c2 \u03af\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03c4\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b3\u03ac\u03c4\u03b5\u03c2, \u03b7 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03cc \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd 4,5 mg\/kg PO q12 hr.<br \/>\n\u03a5\u03c0\u03bf\u03b8\u03ad\u03c4\u03bf\u03bd\u03c4\u03b1\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf Molnupiravir \u03b4\u03b9\u03b1\u03c3\u03c7\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c6\u03c1\u03b1\u03b3\u03bc\u03cc \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2-\u03bc\u03b1\u03c4\u03b9\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c6\u03c1\u03b1\u03b3\u03bc\u03cc \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2-\u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03bf GS-441524 [3,18], \u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af ~1,5 \u03ba\u03b1\u03b9 ~2,0 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03b1\u03c0\u03b5\u03af \u03b7 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b5\u03af\u03c3\u03b4\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c5\u03b4\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03c5\u03b3\u03c1\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03bf\u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03bf \u03c5\u03b3\u03c1\u03cc \u03b3\u03b9\u03b1 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae (~8 mg\/kg PO, q12 h) \u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae FIP (~10 mg\/kg PO, q12 h).<br \/>\n\u0397 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 10-12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03bf GS-441524 [14, 20].<br \/>\n\u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c3\u03c5\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf Molnupiravir \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf.<br \/>\n\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03bf \u03cc\u03c4\u03b9 \u03c4\u03bf Molnupiravir \u03b8\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c3\u03c4\u03b5\u03c1\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf GS-441524 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP, \u03b1\u03bb\u03bb\u03ac \u03ad\u03bd\u03b1 \u03c4\u03c1\u03af\u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03c4\u03bf GS-441524 (\u03c9\u03c2 \u03ba\u03bf\u03ba\u03c4\u03ad\u03b9\u03bb \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2) \u03ae \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03b3\u03b1\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03b1\u03bb\u03ac \u03c3\u03c4\u03bf GS-441524.<br \/>\n\u039f \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c2 \u03ac\u03b3\u03bd\u03c9\u03c3\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03cc\u03c3\u03bf\u03bd \u03c4\u03bf Molnupiravir \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc, \u03b7 N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf [21] \u03ba\u03b1\u03b9 \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd FIP \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf Covid-19 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2.               <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p3\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c4\u03c5\u03c7\u03ad\u03c2 \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf EIDD-1931 (N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7), \u03c4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 Molnupiravir, \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03be\u03b5\u03c4\u03b1\u03c3\u03c4\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03b3\u03b1\u03c4\u03ce\u03bd \u03bc\u03b5 FIP \u03b1\u03c0\u03cc \u03c4\u03bf Molnupiravir.<br \/>\n\u03a4\u03bf EIDD-1931 \u03b5\u03af\u03bd\u03b1\u03b9 4 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03b1\u03c0\u03cc \u03c4\u03bf Molnupiravir (EC50 0,09 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 0,4 uM) \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03ac\u03c0\u03c9\u03c2 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf (2,3% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 3,8% \u03c3\u03b5 100 uM), \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 [15].<br \/>\n\u0397 N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7 \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03ac\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 [3], \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b2\u03b1\u03b8\u03bc\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 EIDD-2801 (Molnupiravir). <span class=\"s5\">\u03a4\u03bf \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03bd\u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 GS-441524 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 Remdesivir, \u03bc\u03b5 \u03c4\u03bf \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03c0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03b7 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c4\u03bf \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03bf [17].<span class=\"Apple-converted-space\"> <\/span><\/span>   <\/p>\n<p class=\"p2\"><b>\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2<span class=\"Apple-converted-space\"> <\/span><\/b><\/p>\n<p class=\"p2\">[1] Painter GR, Natchus MG, Cohen O, Holman W, Painter WP.<br \/>\n\u0391\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03b4\u03c1\u03ce\u03bd\u03c4\u03bf\u03c2, \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03b1\u03bd\u03b4\u03b7\u03bc\u03af\u03b1: \u03b7 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03bf\u03c5 molnupiravir \u03c9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf COVID-19 [\u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03b4\u03af\u03ba\u03c4\u03c5\u03bf \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7, 2021 Jun 18]. <i>Curr Opin Virol<\/i>.<br \/>\n2021;50:17-22.<br \/>\ndoi:10.1016\/j.coviro.2021.06.003   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[2] Halford B. \u0388\u03bd\u03b1\u03c2 \u03b1\u03bd\u03b1\u03b4\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ca\u03cc\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf COVID-19.<br \/>\nc&amp;en topics.<br \/>\n2020.<br \/>\nhttps:\/\/cen.acs.org\/pharmaceuticals\/drug-development\/emerging-antiviral-takes-aim-COVID-19\/98\/web\/2020\/05.   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[3] Painter GR, Richard A. Bowend RA, Bluemling GR et al.<br \/>\n\u0397 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c1\u03b9\u03b2\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03bf\u03c5 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03bd\u03b4\u03bf\u03c1\u03c1\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b9\u03cc \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b9\u03c0\u03c0\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03c4\u03b7\u03c2 \u0392\u03b5\u03bd\u03b5\u03b6\u03bf\u03c5\u03ad\u03bb\u03b1\u03c2.<br \/>\nAntiviral Res. 2019, 171:104597  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[4] Costantini, V.P., Whitaker, T., Barclay, L., Lee, D., McBrayer, T.R., Schinazi, R.F., Vinje,J., 2012. \u0391\u03bd\u03c4\u03b9\u03b9\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c1\u03bf\u03ca\u03bf\u03cd. Antivir. Ther.17 (6), 981-991. https:\/\/doi.org\/10.3851\/imp2229.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[5] Ehteshami, M., Tao, S., Zandi, K., Hsiao, H.M., Jiang, Y., Hammond, E., Amblard, F., Russell, O.O., Merits, A., Schinazi, R.F., 2017.<br \/>\n\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b2-d-N(4)-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7\u03c2 \u03c9\u03c2 \u03bd\u03ad\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd chikungunya.<br \/>\nAntimicrob.<br \/>\nAgents Chemother.<br \/>\n61 (4) e02395-02316.<br \/>\nhttps:\/\/doi.org\/10.1128\/aac.02395-16.     <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[6] Stuyver, L.J., Whitaker, T., McBrayer, T.R., Hernandez-Santiago, B.I., Lostia, S., Tharnish, P.M., Ramesh, M., Chu, C.K., Jordan, R., Shi, J., Rachakonda, S., Watanabe, K.A., Otto, M.J., Schinazi, R.F., 2003.<br \/>\n\u03a1\u03b9\u03b2\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03b9\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03c9\u03bd \u03b9\u03ce\u03bd \u03c4\u03b7\u03c2 \u03b9\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b4\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2\u03bf\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 C \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1.<br \/>\nAntimicrob.<br \/>\nAgents Chemother.<br \/>\n47 (1), 244-254.    <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[7] Yoon J., Toots M, Lee S, Lee ME, et al., 2018.<br \/>\n\u0391\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c1\u03b9\u03b2\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ad\u03bf\u03c2 \u03c6\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 <span class=\"Apple-converted-space\"> <\/span>\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b9\u03ce\u03bd \u03c4\u03b7\u03c2 \u03b3\u03c1\u03af\u03c0\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03b3\u03ba\u03c5\u03c4\u03af\u03bf\u03c5.<br \/>\nAntimicrob.<br \/>\nAgents Chemother.<br \/>\n2018, 62 (8):https:\/\/doi.org\/10.1128\/aac.00766-18 6   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[8].<br \/>\nUrakova N, Kuznetsova V, Crossman DK, Sokratian A, Guthrie DB, Kolykhalov AA, et al.<br \/>\n\u0397 \u03b2-d-N4-Hydroxycytidine \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ad\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03c4\u03c9\u03bd \u03b1\u03c6\u03c1\u03bf\u03b4\u03af\u03c3\u03b9\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c5\u03c8\u03b7\u03bb\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b9\u03b9\u03ba\u03cc \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1.<br \/>\nJ Virol.<br \/>\n2018, 92:e01965-e01917.<br \/>\ndoi: 10.1128\/JVI.01965-17.     <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[9] Pyrc, K., Bosch, B.J., Berkhout, B., Jebbink, M.F., Dijkman, R., Rottier, P., van der Hoek,L., 2006. \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bc\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03cc NL63 \u03c3\u03c4\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2. Antimicrob. Agents Chemother. 2006, 50(6):2000-2008. https:\/\/doi.org\/10.1128\/aac.01598-05.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[10].<br \/>\nWhitfill T. A likely new treatment for Covid-19 was made possible by government-funded innovation.<br \/>\nSTAT+.<br \/>\nhttps:\/\/www.statnews.com\/2021\/10\/05\/government-funding-backed-molnupiravir-possible-new-covid-19-treatment\/.   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[11]  Painter, G.R., Guthrie, D.B., Bluemling, G., Natchus, M.G. N4-Hydroxycytidine and Derivatives and Anti-viral Uses Related Hero.<br \/>\n\u0391\u03af\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b4\u03af\u03c0\u03bb\u03c9\u03bc\u03b1 \u03b5\u03c5\u03c1\u03b5\u03c3\u03b9\u03c4\u03b5\u03c7\u03bd\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u0397\u03a0\u0391, 2016, 2016\/106050 A1. <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[12]  \u0394\u03b5\u03bb\u03c4\u03af\u03bf \u03c4\u03cd\u03c0\u03bf\u03c5 \u03c4\u03b7\u03c2 Merck, 1 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5 2021.<br \/>\nhttps:\/\/www.merck.com\/news\/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat\/. <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[13]  Pedersen NC, Kim Y, Liu H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC, Bannasch M, Meadows JM, Chang KO.<br \/>\n\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 3C \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03b4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03b1\u03b9\u03bb\u03bf\u03c5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd.<br \/>\nJ Feline Med Surg. 2018, 20(4):378-392.  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[14]  Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03bf\u03c5 GS-441524 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b1\u03c4\u03ce\u03bd \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ce\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bb\u03bf\u03b9\u03bc\u03ce\u03b4\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03af\u03c4\u03b9\u03b4\u03b1 \u03b1\u03b9\u03bb\u03bf\u03c5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd.<br \/>\nJ Feline Med Surg. 2019, 21(4):271-281. <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[15]  Cook SE, Vogel H \u03ba\u03b1\u03b9 D. Castillo D. \u039c\u03b9\u03b1 \u03bf\u03c1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03cc \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03c1\u03bf\u03bd\u03b1\u03ca\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03b1\u03ca\u03bf\u03cd \u03c4\u03c9\u03bd \u03b1\u03b9\u03bb\u03bf\u03c5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd.<br \/>\n2021.<br \/>\nbioRxiv 2020.07.09.195016; doi: https:\/\/doi.org\/10.1101\/2020.07.09.195016  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[16]  Zhang S. \u0388\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf COVID-19 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c0\u03b1\u03bd\u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03b3\u03ac\u03c4\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b1\u03cd\u03c1\u03b7\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2.<br \/>\n\u039c\u03ac\u03b9\u03bf\u03c2 8, 2020 <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">Shutterstock \/ The Atlantic, https:\/\/www.theatlantic.com\/science\/archive\/2020\/05\/remdesivir-cats\/611341\/.<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[17]  Yan VC, Muller FL.<br \/>\n\u03a0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03af\u03bf\u03c5 GS-441524 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 Remdesivir \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 Covid-19.<br \/>\nACS Medicinal Chemistry Letters.<br \/>\n2020, <i>11 <\/i>(7):1361-1366 DOI: 10.1021\/acsmedchemlett.0c00316   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[18]  Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC.<br \/>\n\u03a4\u03bf \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c3\u03b9\u03b4\u03b9\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf GS-441524 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c4\u03bf\u03bd \u03b9\u03cc \u03c4\u03b7\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03b4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bb\u03bf\u03c5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd (FIP) \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 \u03b3\u03ac\u03c4\u03b1\u03c2.Vet Microbiol.<br \/>\n2018, 219:226-233.  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[19].<br \/>\nCommon Dreams.<br \/>\nPublic citizen.<br \/>\nPress release, August 4, 2020, https:\/\/www.commondreams.org\/newswire\/2020\/08\/04\/public-citizen-scientists-gilead-and-federal-scientists-have-neglected 7   <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[20]  Dickinson PJ.<br \/>\n\u039c\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7 \u03c4\u03bf\u03c5 \u039a\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u039d\u03b5\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03a3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03cc: Covid-19.<br \/>\nFront.<br \/>\nVet.<br \/>\nSci.<br \/>\n2020, 23: https:\/\/doi.org\/10.3389\/fvets.2020.584673     <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[21]  Zhou S, Hill CS, Sarkar S, et al., \u0397 <span class=\"s6\">\u03b2-d-N4-\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03ba\u03c5\u03c4\u03b9\u03b4\u03af\u03bd\u03b7<\/span> \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf\u03bd SARS-CoV-2 \u03bc\u03ad\u03c3\u03c9 \u03b8\u03b1\u03bd\u03b1\u03c4\u03b7\u03c6\u03cc\u03c1\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03be\u03b9\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03be\u03b9\u03b3\u03cc\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b8\u03b7\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd.<br \/>\nJ Infect Dis.<br \/>\n2021, 224:415-419, https:\/\/doi.org\/10.1093\/infdis\/jiab247.  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[22]  Cohen J, Piller C. \u03a4\u03b1 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bd\u03b9\u03ba\u03ac \u03bc\u03b7\u03bd\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03bc\u03b1\u03c4\u03b9\u03ac \u03c3\u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03bf\u03b4\u03cc\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03bb\u03b1\u03c4\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c3\u03c7\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf COVID-19.<br \/>\nScienceInsider-Health.<br \/>\n2020, https:\/\/www.science.org\/news\/2020\/05\/emails-offer-look-whistleblower-charges-cronyism-behind-potential-covid-19-drug.  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[23]  Agostini ML, Andres EL, Sims AC, et al.<br \/>\n\u0397 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03b1\u03ca\u03bf\u03cd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b9\u03ba\u03ae \u03c1\u03b5\u03bc\u03b4\u03b5\u03c3\u03b9\u03b2\u03af\u03c1\u03b7 (GS-5734) \u03b4\u03b9\u03b1\u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03bf\u03c1\u03c1\u03b9\u03b2\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ac\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b9\u03cc. <i>MBio <\/i>2018; 9.<br \/>\nDOI: 10.1128\/mBio.00221-18.  <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[24]  Szemiel AM, Merits A, Orton RJ, \u0397 <i>in vitro <\/i>\u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf Remdesivir \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03bb\u03b9\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b2\u03bb\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 SARS-CoV-2.<br \/>\nPlos Path, 2021,https:\/\/doi.org\/10.1371\/journal.ppat.1009929 . <span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[25]  Martinot M, Jary A, Fafi-Kremer S, et al., Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019, <i>Clinical Infectious Diseases<\/i>, 2020;, ciaa1474, https:\/\/doi.org\/10.1093\/cid\/ciaa1474<span class=\"Apple-converted-space\"> <\/span><\/p>\n<p class=\"p2\">[26]  FIP Warriors CZ\/SK <span class=\"s7\">&#8211; EIDD-2801 <\/span>(Molnupiravir)<span class=\"Apple-converted-space\"> <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u03a0\u03bf\u03bb\u03bb\u03bf\u03af \u03b9\u03b4\u03b9\u03bf\u03ba\u03c4\u03ae\u03c4\u03b5\u03c2 \u03b3\u03ac\u03c4\u03b1\u03c2 \u03bc\u03b5 FIP \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf Molnupiravir \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf GS441524 \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b3\u03ac\u03c4\u03b1 \u03c4\u03bf\u03c5\u03c2. \u0397 \u03b1\u03bb\u03ae\u03b8\u03b5\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FIP \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf Molnupiravir \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c7\u03bf\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03bd\u03b1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22631,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_glsr_average":0,"_glsr_ranking":0,"_glsr_reviews":0,"footnotes":""},"categories":[852],"tags":[],"_links":{"self":[{"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/pages\/22630"}],"collection":[{"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/comments?post=22630"}],"version-history":[{"count":0,"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/pages\/22630\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/media\/22631"}],"wp:attachment":[{"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/media?parent=22630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/categories?post=22630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fipmed.co\/el\/wp-json\/wp\/v2\/tags?post=22630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}