{"id":17177,"date":"2024-03-28T04:32:29","date_gmt":"2024-03-28T04:32:29","guid":{"rendered":"https:\/\/fipmed.co\/%e3%83%a2%e3%83%ab%e3%83%8c%e3%83%94%e3%83%a9%e3%83%93%e3%83%ab-%e7%ac%ac3%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e8%96%ac%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e3%83%95%e3%82%a3%e3%83%83\/"},"modified":"2024-05-10T07:01:51","modified_gmt":"2024-05-10T07:01:51","slug":"fip-%e3%83%a2%e3%83%ab%e3%83%8c%e3%83%94%e3%83%a9%e3%83%93%e3%83%ab%e3%81%aefip%e6%b2%bb%e7%99%82%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%ac%ac3%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9","status":"publish","type":"page","link":"https:\/\/fipmed.co\/ja\/fip-%e3%83%a2%e3%83%ab%e3%83%8c%e3%83%94%e3%83%a9%e3%83%93%e3%83%ab%e3%81%aefip%e6%b2%bb%e7%99%82%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%ac%ac3%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9\/","title":{"rendered":"FIP \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306eFIP\u6cbb\u7642\u306b\u304a\u3051\u308b\u7b2c3\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u3057\u3066"},"content":{"rendered":"<p class=\"p2\"><span class=\"s1\"><span class=\"Apple-converted-space\">\u30d5\u30a3\u30c3\u30d7\u732b\u306e\u98fc\u3044\u4e3b\u306e\u591a\u304f\u306f\u3001\u98fc\u3044\u732b\u306e\u6cbb\u7642\u306b\u95a2\u3057\u3066FIP\u00a0 \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3068GS441524\u306e\u4e21\u65b9\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u3002 \u5b9f\u969b\u306e\u3068\u3053\u308d\u3001\u3069\u3061\u3089\u306e\u6cbb\u7642\u6cd5\u3082FIP\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u3002 \u3057\u304b\u3057\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u7d30\u80de\u6bd2\u6027\u304c\u5f37\u304f\u3001\u9078\u629e\u3059\u308b\u306b\u306f\u975e\u5e38\u306b\u5371\u967a\u306a\u85ac\u5264\u3067\u3042\u308b\u3002 <\/span><\/span><\/p>\n<p class=\"p2\"><strong><span class=\"s1\"><br \/>\n<span class=\"Apple-converted-space\">\u4ee5\u4e0b\u306fDr. <\/span><br \/>\n<\/span><i>Niels C. Pedersen DVM,<span class=\"Apple-converted-space\"> PhD\u304b\u3089\u306e <\/span>\u5831\u544a\u3067\u3042\u308b\u3002 <\/i><i>2021\u5e7410\u670820\u65e5 <\/i> <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p2\"><span class=\"s2\"><span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u30d7\u30ed\u30c9\u30e9\u30c3\u30b0\u3067\u3042\u308b\u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306f <\/span>\u30011970\u5e74\u4ee3\u5f8c\u534a\u306b\u65e7\u30bd\u9023\u3067\u751f\u7269\u5175\u5668\u7814\u7a76\u306e\u4e00\u74b0\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u305f\u4f4e\u5206\u5b50\uff08\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\uff09\u3067\u3042\u308b[2]\u3002 \u5929\u7136\u75d8\u306e\u3088\u3046\u306a\u75c5\u6c17\u306e\u5175\u5668\u5316\u306f\u4e16\u754c\u7684\u306b\u6050\u308c\u3089\u308c\u3066\u3044\u305f\u304c\u3001\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u3092\u3053\u306e\u76ee\u7684\u306b\u4f7f\u7528\u3059\u308b\u5371\u967a\u6027\u306f\u3042\u307e\u308a\u306b\u3082\u5927\u304d\u304b\u3063\u305f\u3002 \u5929\u7136\u75d8\u306f\u4e16\u754c\u304b\u3089\u6839\u7d76\u3055\u308c\u3001\u4e8b\u5b9f\u4e0a\u3059\u3079\u3066\u306e\u5728\u5eab\u304c\u7834\u68c4\u3055\u308c\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u7981\u6b62\u3055\u308c\u305f\u3002 \u3053\u306e\u305f\u3081\u3001\u7c73\u30bd\u4e21\u56fd\u306f\u751f\u7269\u5175\u5668\u3068\u3057\u3066\u306e\u4ed6\u306eRNA\u30a6\u30a4\u30eb\u30b9\u3084\u3001\u305d\u308c\u3092\u9632\u5fa1\u3059\u308b\u305f\u3081\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u5264\u306e\u7814\u7a76\u306b\u7740\u624b\u3057\u305f\u3002 \u30d9\u30cd\u30ba\u30a8\u30e9\u99ac\u8133\u810a\u9ac4\u708e\u30a6\u30a4\u30eb\u30b9\uff08VEEV\uff09\u306f\u3001\u751f\u7269\u5175\u5668\u3068\u3057\u3066\u771f\u5263\u306b\u691c\u8a0e\u3055\u308c\u305f\u6700\u521d\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u3072\u3068\u3064\u3067\u3042\u308b[3]\u3002 VEEV\u306f\u868a\u306b\u523a\u3055\u308c\u308b\u3053\u3068\u3067\u4eba\u306b\u611f\u67d3\u3057\u3001\u9ad8\u71b1\u3001\u982d\u75db\u3001\u8133\u708e\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u6b7b\u306b\u81f3\u308b\u3053\u3068\u3082\u3042\u308b\u816b\u308c\u3092\u8d77\u3053\u3059\u3002 \u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306fVEEV\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30dc\u30e9\u51fa\u8840\u71b1\u3001\u30c1\u30af\u30f3\u30b0\u30cb\u30a2\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u3001\u30ce\u30ed\u30a6\u30a4\u30eb\u30b9\u3001\u725b\u4e0b\u75e2\u30a6\u30a4\u30eb\u30b9\u3001C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u3001\u547c\u5438\u5668\u5408\u80de\u4f53\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u3001\u5e45\u5e83\u3044\u30a2\u30eb\u30d5\u30a1\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002[3-8] \u3002 \u30d2\u30c8\u30fb\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9NL<span class=\"s2\">63\u306b\u5bfe\u3059\u308b <\/span>\u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306e\u963b\u5bb3\u52b9\u679c\u306b\u95a2\u3059\u308b\u6700\u3082\u53e4\u3044\u5831\u544a\u306f2006\u5e74\u3067\u3042\u3063\u305f [9]\u3002 \u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u5e83\u7bc4\u306a\u30d2\u30c8\u304a\u3088\u3073\u52d5\u7269\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b[8]\u3002<\/p>\n<p class=\"p2\">\u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306e\u6700\u8fd1\u306e\u6b74\u53f2\u306e\u91cd\u8981\u306a\u90e8\u5206\u306f\u3001\u30a8\u30e2\u30ea\u30fc\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u6240\uff08EIDD\uff09\u306b\u7531\u6765\u3057 [1]\u3001\u305d\u306e\u5b9f\u9a13\u540d\u306fEIDD-1931\u3067\u3042\u3063\u305f\u3002 \u30a8\u30e2\u30ea\u30fc\u5927\u5b66\u306e\u3088\u3046\u306a\u6a5f\u95a2\u306b\u304a\u3051\u308b\u30a2\u30eb\u30d5\u30a1\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u7814\u7a76\u306b\u306f\u30012004\u5e74\u307e\u3067\u3055\u304b\u306e\u307c\u308b\u304c\u3001\u7c73\u56fd\u653f\u5e9c\u304b\u3089\u591a\u984d\u306e\u8ca1\u653f\u7684\u652f\u63f4\u304c\u63d0\u4f9b\u3055\u308c\u3066\u304a\u308a\u3001\u73fe\u5728[10] \u3002 \u56fd\u9632\u8105\u5a01\u524a\u6e1b\u5c40\u306f2014\u5e74\u3001VEEV\u3084\u305d\u306e\u4ed6\u306e\u30a2\u30eb\u30d5\u30a1\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u5316\u5408\u7269\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u3092\u76ee\u6a19\u306b\u3001\u7d44\u7e54\u7684\u306a\u652f\u63f4\u3092\u884c\u3063\u305f\u3002 \u300cN4-Hydroxycytidine and derivatives and anti-viral Uses related to that &#8220;\u306f\u30012016\u5e74\u306b\u7c73\u56fd\u7279\u8a31\u51fa\u98582016\/106050 A1\uff08[11] \uff09\u3067\u30ab\u30d0\u30fc\u3055\u308c\u3066\u3044\u308b\u3002 2019\u5e74\u306b\u306f\u3001\u56fd\u7acb\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u304b\u3089\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6cbb\u7642\u306e\u305f\u3081\u306e\u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306e\u30a8\u30b9\u30c6\u30eb\u5316\u30d7\u30ed\u30c9\u30e9\u30c3\u30b0\uff08EIDD-2801\uff09\u306e\u63d0\u643a\u7814\u7a76\u3078\u306e\u8ffd\u52a0\u8cc7\u91d1\u304c\u63d0\u4f9b\u3055\u308c\u305f[10] \u3002 EIDD-2801\u306e\u5316\u5b66\u7684\u5909\u66f4\u306e\u610f\u56f3\u306f\u3001\u7d4c\u53e3\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3042\u308a\u3001\u6700\u7d42\u7684\u306b\u306f\u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u304c\u3001EIDD-2801\u306e\u7d4c\u53e3\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u306b\u3042\u308b\u3002\u6ce8\u5c04\u3067\u306f\u306a\u304f\u9320\u5264\u3068\u3057\u3066\u6295\u4e0e\u3055\u308c\u308b\u3002 \u7814\u7a76\u306e\u91cd\u70b9\u304c\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u304b\u3089SARS-II CoV\u306b\u5207\u308a\u66ff\u308f\u3063\u305f\u306e\u306f2019\/2020\u5e74\u306e\u3053\u3068\u3067\u3042\u308b[2]\u3002 EIDD-2801\u306e\u5546\u696d\u5316\u306f\u30ea\u30c3\u30b8\u30a6\u30a7\u30a4\u30fb\u30d0\u30a4\u30aa\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u3068\u3044\u3046\u30a8\u30e2\u30ea\u30fc\u306e\u95a2\u9023\u4f1a\u793e\u306b\u59d4\u306d\u3089\u308c\u3001\u30ea\u30c3\u30b8\u30a6\u30a7\u30a4\u30fb\u30d0\u30a4\u30aa\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306f\u305d\u306e\u5f8c\u30e1\u30eb\u30af\u3068\u63d0\u643a\u3057\u3001\u9577\u304f\u8cbb\u7528\u306e\u304b\u304b\u308bFDA\u306e\u627f\u8a8d\u624b\u7d9a\u304d\u3092\u884c\u3063\u305f\u3002 EIDD-2081\u306e\u73fe\u5728\u306e\u5b9f\u5730\u8a66\u9a13\u30d0\u30fc\u30b8\u30e7\u30f3\u306f <span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3068\u547d\u540d\u3055\u308c\u305f\u3002<\/p>\n<p class=\"p2\"><span class=\"s2\"><span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u6709\u52b9\u6210\u5206 <\/span>\u3067\u3042\u308b\u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306f\u3001\u4e92\u5909\u7570\u6027\u4f53\u3068\u3057\u30662\u3064\u306e\u5f62\u614b\u3067\u5b58\u5728\u3059\u308b\u3002 \u3042\u308b\u5f62\u3067\u306f\u3001\u70ad\u7d20\u3068N-OH\u57fa\u306e\u9593\u306b\u5358\u7d50\u5408\u3092\u6301\u3064\u30b7\u30c1\u30b8\u30f3\u3092\u6a21\u5023\u3057\u3066\u3044\u308b\u3002 \u30a6\u30ea\u30b8\u30f3\u3092\u6a21\u5023\u3057\u305f\u5225\u306e\u5f62\u3067\u306f\u3001\u70ad\u7d20\u3068N-OH\u57fa\u306e\u9593\u306b\u4e8c\u91cd\u7d50\u5408\u3092\u6301\u3064\u30aa\u30ad\u30b7\u30e0\u3092\u6301\u3064\u3002 \u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u30a6\u30a4\u30eb\u30b9RNA\u4f9d\u5b58\u6027RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306f\u30b7\u30c1\u30b8\u30f3\u306e\u4ee3\u308f\u308a\u306b\u30a6\u30ea\u30b8\u30f3\u3092\u8aad\u307f\u3001\u30b0\u30a2\u30ce\u30b7\u30f3\u306e\u4ee3\u308f\u308a\u306b\u30a2\u30c7\u30ce\u30b7\u30f3\u3092\u633f\u5165\u3059\u308b\u3002 \u30a6\u30a4\u30eb\u30b9\u306e\u5f62\u614b\u304c\u5207\u308a\u66ff\u308f\u308b\u3068\u3001\u8ee2\u5199\u306e\u969b\u306b\u30df\u30b9\u30de\u30c3\u30c1\u304c\u8d77\u3053\u308a\u3001\u305d\u306e\u7d50\u679c\u3001\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306b\u591a\u304f\u306e\u5909\u7570\u304c\u751f\u3058\u3001\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u304c\u505c\u6b62\u3059\u308b[8]\u3002<\/p>\n<h4 class=\"p2\">\u30e1\u30eb\u30af\u793e\u306b\u3088\u308bFIP \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306eFDA\u306b\u3088\u308b\u6761\u4ef6\u4ed8\u304d\u627f\u8a8d\u304a\u3088\u3073\u5b8c\u5168\u627f\u8a8d\u3078\u306e\u524d\u9032\u306f\u52a0\u901f\u3057\u3066\u3044\u308b\u3002 \u30e1\u30eb\u30af\u793e\u306f\u4f01\u696d\u58f0\u660e\u306e\u4e2d\u3067\u3001\u6b21\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u308b\u3002[12] &#8211;<i>&#8220;In anticipation of results <\/i>2<\/h4>\n<p class=\"p2\"><i>MOVe-OUT\u304b\u3089\u3001\u30e1\u30eb\u30af\u793e\u306f\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3092\u30ea\u30b9\u30af\u751f\u7523\u3057\u3066\u3044\u308b\u3002\u30e1\u30eb\u30af\u793e\u306f\u30012021\u5e74\u672b\u307e\u3067\u306b1,000\u4e07\u30b3\u30fc\u30b9\u306e\u6cbb\u7642\u3092\u751f\u7523\u3057\u30012022\u5e74\u306b\u306f\u3055\u3089\u306b\u591a\u304f\u306e\u7528\u91cf\u3092\u751f\u7523\u3059\u308b\u898b\u8fbc\u307f\u3067\u3042\u308b\u3002&#8230;&#8230;..\u30e1\u30eb\u30af\u306f\u3001Molnupiravir\u304c\u627f\u8a8d\u307e\u305f\u306f\u8a8d\u53ef\u3055\u308c\u305f\u5834\u5408\u3001\u30b0\u30ed\u30fc\u30d0\u30eb\u306b\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u30a2\u30af\u30bb\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u7d04\u675f\u3057\u3001\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306b\u5bfe\u3059\u308b\u4fdd\u5065\u533b\u7642\u5bfe\u5fdc\u3078\u306e\u8cc7\u91d1\u8abf\u9054\u80fd\u529b\u3092\u76f8\u5bfe\u7684\u306b\u53cd\u6620\u3059\u308b\u305f\u3081\u3001\u4e16\u754c\u9280\u884c\u306e\u56fd\u5225\u6240\u5f97\u57fa\u6e96\u306b\u57fa\u3065\u304f\u6bb5\u968e\u7684\u306a\u4fa1\u683c\u8a2d\u5b9a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u5b9f\u65bd\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002&#8230;&#8230; .\u30e1\u30eb\u30af\u306f\u3001\u30b0\u30ed\u30fc\u30d0\u30eb\u30fb\u30a2\u30af\u30bb\u30b9\u306e\u62e1\u5927\u3078\u306e\u30b3\u30df\u30c3\u30c8\u30e1\u30f3\u30c8\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u73fe\u5730\u306e\u898f\u5236\u5f53\u5c40\u306b\u3088\u308b\u627f\u8a8d\u307e\u305f\u306f\u7dca\u6025\u627f\u8a8d\u5f8c\u3001100\u3092\u8d85\u3048\u308b\u4e2d\u4f4e\u6240\u5f97\u56fd\uff08LMICs\uff09\u3067\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u5165\u624b\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u3001\u65e2\u5b58\u306e\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u533b\u85ac\u54c1\u30e1\u30fc\u30ab\u30fc\u3068\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u975e\u72ec\u5360\u7684\u306a\u4efb\u610f\u30e9\u30a4\u30bb\u30f3\u30b9\u5951\u7d04\u3092\u7de0\u7d50\u3057\u305f\u3053\u3068\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002 <\/i>\u3053\u306e &#8220;\u5bdb\u5927\u3055 &#8220;\u304c\u52d5\u7269\u5229\u7528\u306b\u3082\u9069\u7528\u3055\u308c\u308b\u3068\u306f\u8003\u3048\u306b\u304f\u3044\u3002<\/p>\n<p class=\"p2\">\u4eca\u56de\u306eCovid-19\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306e\u539f\u56e0\u7269\u8cea\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u306f\u3001\u904e\u53bb2\u5e74\u9593\u306b\u6025\u901f\u306b\u30d5\u30a3\u30fc\u30eb\u30c9\u30c6\u30b9\u30c8\u304c\u884c\u308f\u308c\u3001\u305d\u306e\u3046\u3061\u306e1\u3064\u3067\u3042\u308b\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306f\u3001\u5165\u9662\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u8a18\u9332\u7684\u306a\u901f\u3055\u3067\u627f\u8a8d\u3055\u308c\u305f\u3002 \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u3001\u65e9\u671f\u611f\u67d3\u75c7\u306e\u5728\u5b85\u6cbb\u7642\u7528\u7d4c\u53e3\u85ac\u3068\u3057\u3066\u3001\u6628\u5e74\u4e2d\u306b\u6761\u4ef6\u4ed8\u304d\u627f\u8a8d\u306b\u5411\u3051\u3066\u52d5\u304d\u51fa\u3057\u305f[12] \u3002 \u3057\u304b\u3057\u3001\u6709\u52b9\u306a\u6297\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u5316\u5408\u7269\u306f\u3001\u732b\u306b\u591a\u304f\u898b\u3089\u308c\u308b\u3082\u3046\u4e00\u3064\u306e\u75c5\u6c17\u3067\u3042\u308b\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\uff08FIP\uff09\u306b\u5bfe\u3057\u3066\u65e9\u304f\u304b\u3089\u958b\u767a\u3055\u308c\u3066\u3044\u305f\u3002 \u3053\u308c\u3089\u306e\u85ac\u5264\u306b\u306f\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u5264\uff08GC376\uff09[13] \u3001Remdesivir[14] \u306e\u6d3b\u6027\u90e8\u5206\u3067\u3042\u308bRNA\u4f9d\u5b58\u6027RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\uff08GS-441524\uff09\u304c\u542b\u307e\u308c\u308b\u3002 \u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306b\u3088\u308bFIP\u306e\u6cbb\u7642\u304c\u6210\u529f\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u6700\u8fd1\u3001EIDD-1931\u3068EIDD-2801\u306e\u4e21\u65b9\u306b\u3064\u3044\u3066\u3001\u7d44\u7e54\u57f9\u990a\u306b\u304a\u3051\u308bFIPV\u3092\u963b\u5bb3\u3059\u308b\u80fd\u529b\u306b\u3064\u3044\u3066\u7814\u7a76\u304c\u884c\u308f\u308c\u305f[15] \u3002 FIPV\u306b\u5bfe\u3059\u308bEIDD-1931\u306e\u6709\u52b9\u6fc3\u5ea6-50\uff05\uff08EC50\uff09\u306f0.09uM\u3001EIDD-2801\u306f0.4uM\u3001GS-441524\u306f0.66Um[15] \u3067\u3042\u3063\u305f\u3002<strong> 100uM\u3067\u306e\u7d30\u80de\u6bd2\u6027\u30d1\u30fc\u30bb\u30f3\u30c8\u306f\u3001\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u3067\u305d\u308c\u305e\u308c2.8\u30013.8\u30010\u3067\u3042\u3063\u305f\u3002 \u5f93\u3063\u3066\u3001EIDD-1931\u3068-2801\u306fGS-441524\u3088\u308a\u3082\u308f\u305a\u304b\u306b\u30a6\u30a4\u30eb\u30b9\u963b\u5bb3\u4f5c\u7528\u304c\u5f37\u3044\u304c\u3001\u7d30\u80de\u6bd2\u6027\u3082\u5f37\u3044\u3002<\/strong> \u3053\u308c\u3089\u306e\u5b9f\u9a13\u5ba4\u7814\u7a76\u306f\u3001EIDD-1931\u3068EIDD-2801\u304cFIP\u6cbb\u7642\u306e\u512a\u308c\u305f\u5019\u88dc\u3067\u3082\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n<p class=\"p2\">EIDD-1931\u3068EIDD-2801\u306fFIP\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u5927\u3044\u306b\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u304c\u3059\u3050\u306b\u5408\u6cd5\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u3092\u4f4e\u304f\u3057\u3066\u3044\u308b\u3044\u304f\u3064\u304b\u306e\u969c\u5bb3\u304c\u3042\u308b\u3002 \u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306e\u6d3b\u6027\u578b\u3067\u3042\u308bGS-441524\u306f\u30ae\u30ea\u30a2\u30c9\u30fb\u30b5\u30a4\u30a8\u30f3\u30b7\u30ba\u304c\u7279\u8a31\u3092\u53d6\u5f97\u3057\u3066\u304a\u308a\u3001Covid-19\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u304c\u8d77\u3053\u308b\u5c11\u3057\u524d\u306bFIP\u306e\u732b\u306b\u4f7f\u7528\u3059\u308b\u305f\u3081\u306b\u7814\u7a76\u3055\u308c\u305f\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u3092SARS\u69d8\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3067\u306f\u306a\u304f\u3001\u30a8\u30dc\u30e9\u30a6\u30a4\u30eb\u30b9\u306b\u4f7f\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u3063\u305f\u3053\u3068\u304c\u3001FIP\u306e\u7814\u7a76\u3092\u4fc3\u3057\u305f\u306e\u3067\u3042\u308b[14] \u3002 [16]\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u30ae\u30ea\u30a2\u30c9\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u306e\u79d1\u5b66\u8005\u3068\u5171\u540c\u3067\u884c\u308f\u308c\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u540c\u793e\u306fGS-441524\u306e\u52d5\u7269\u5b9f\u9a13\u3092\u62d2\u5426\u3057\u305f\u3002 \u540c\u69d8\u306b\u3001\u30a8\u30e2\u30ea\u30fc\u5927\u5b66\u3001\u30ea\u30c3\u30b8\u30d0\u30c3\u30af\u30fb\u30d0\u30a4\u30aa\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u3001\u30e1\u30eb\u30af\u793e\u7363\u533b\u5b66\u90e8\u9580\u306b\u5bfe\u3057\u3066\u3001\u732b\u306eFIP\u306b\u5bfe\u3059\u308bEIDD-1931\u3068EIDD-2801\u306e\u7814\u7a76\u3092\u3053\u30532-3\u5e74\u8a66\u307f\u3066\u3082\u3001\u56de\u7b54\u304c\u306a\u3044\u304b\u62d2\u5426\u3055\u308c\u305f\u3002\u30ae\u30ea\u30a2\u30c9\u793e\u304cGS-441524\u306e\u52d5\u7269\u5b9f\u9a13\u3092\u62d2\u5426\u3057\u305f\u7406\u7531\u3068\u540c\u69d8\u306e\u7406\u7531\u3067\u3042\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u306a\u3044\u3002 \u3057\u304b\u3057\u3001FIP\u6cbb\u7642\u85ac\u306b\u5bfe\u3059\u308b\u4e16\u754c\u7684\u306a\u30cb\u30fc\u30ba\u306f\u9ad8\u304f\u3001GS-441524\u306e\u672a\u627f\u8a8d\u5e02\u5834\u306f\u4e2d\u56fd\u304b\u3089\u6025\u901f\u306b\u62e1\u5927\u3057\u305f\u3002 \u3053\u306e\u3088\u3046\u306aFIP\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u304b\u3089\u3001\u6700\u8fd1\u3001FIP\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3078\u306e\u95a2\u5fc3\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3002<\/p>\n<p class=\"p2\">EIDD-1931\u3068EIDD-2801\/\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3001GS-441524\u3068\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306e\u72b6\u6cc1\u306f\u3001\u306a\u305c\u4e00\u90e8\u306e\u533b\u85ac\u54c1\u304c\u5e02\u8ca9\u306e\u305f\u3081\u306b\u30d7\u30ed\u30c9\u30e9\u30c3\u30b0\u306b\u5909\u66f4\u3055\u308c\u308b\u306e\u304b\u7591\u554f\u3092\u6295\u3052\u304b\u3051\u3066\u3044\u308b[17] \u3002 \u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u30a8\u30b9\u30c6\u30eb\u5316\u3055\u308c\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u30cd\u30b3\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f\u3001GS-441524\u3068\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306f\u7d44\u7e54\u57f9\u990a\u3067\u540c\u7a0b\u5ea6\u306e\u30a6\u30a4\u30eb\u30b9\u963b\u5bb3\u6d3b\u6027\u3092\u793a\u3057\u305f[18] \u3002 \u3057\u304b\u3057\u3001\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306f\u7d4c\u53e3\u6295\u4e0e\u3067\u306f\u5438\u53ce\u304c\u60aa\u3044\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u305f\u3081\u3001\u6761\u4ef6\u4ed8\u304d\u3067\u6ce8\u5c04\u5264\u306e\u307f\u304c\u627f\u8a8d\u3055\u308c\u305f\u3002 EIDD-2801\u306f\u3001EIDD-1931\u306e\u7d4c\u53e3\u5438\u53ce\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u5275\u88fd\u3055\u308c\u305f\u304c\u3001\u305d\u308c\u4ee5\u524d\u306e\u7814\u7a76\u3067\u306f\u3001EIDD-1931\u306f\u30a8\u30b9\u30c6\u30eb\u5316\u3057\u306a\u304f\u3066\u3082\u7d4c\u53e3\u7684\u306b\u5341\u5206\u306b\u5438\u53ce\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u305f[6]\u3002 [17]GS-441524\u306e\u4ee3\u308f\u308a\u306b\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u3092\u30d2\u30c8\u306b\u4f7f\u7528\u3059\u308b\u305f\u3081\u306b\u5546\u54c1\u5316\u3057\u305f\u52d5\u6a5f\u306f\u79d1\u5b66\u7684\u306b\u7591\u554f\u8996\u3055\u308c\u3066\u3044\u308b\u3002 EIDD-2801[15] \u3001EIDD-1931\u306e\u65b9\u304c\u5b89\u4fa1\u3067\u30014\u500d\u306e\u30a6\u30a4\u30eb\u30b9\u6291\u5236\u52b9\u679c\u304c\u3042\u308a\u3001\u6bd2\u6027\u30823\u5206\u306e1\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u306a\u305cEIDD-2801\u304c\u5546\u54c1\u5316\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u7279\u8a31\u6a29\u306e\u5f37\u3055\u3068\u7279\u8a31\u306e\u5b58\u7d9a\u671f\u9593\u306f\u3001\u3053\u308c\u3089\u306e\u6c7a\u5b9a\u306b\u304a\u3044\u3066\u3088\u308a\u8aac\u5f97\u529b\u306e\u3042\u308b\u8981\u56e0\u304b\u3082\u3057\u308c\u306a\u3044[16, 17, 19]\u3002<\/p>\n<p class=\"p2\">\u732b\u306eFIP\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u554f\u984c\u306e\u3072\u3068\u3064\u306f\u3001\u8840\u6db2-\u773c\u304a\u3088\u3073\u8840\u6db2-\u8133\u9593\u306e\u969c\u58c1\u3067\u3042\u308a\u3001\u3053\u306e\u969c\u58c1\u306f\u773c\u304a\u3088\u3073\/\u307e\u305f\u306f\u8133\u306b\u75c5\u6c17\u304c\u53ca\u3076\u3068\u975e\u5e38\u306b\u91cd\u8981\u306b\u306a\u308b[13, 14, 20]\u3002 \u3053\u306e\u554f\u984c\u306f\u3001GS-441524\u3092\u7528\u3044\u305f\u773c\u578b\u304a\u3088\u3073\u795e\u7d4c\u578b\u306eFIP\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u8840\u4e2d\u6fc3\u5ea6\u3092\u4e0a\u3052\u308b\u305f\u3081\u306b\u6295\u4e0e\u91cf\u3092\u5f90\u3005\u306b\u5897\u3084\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u623f\u6c34\u304a\u3088\u3073\uff0f\u307e\u305f\u306f\u8133\u5185\u306e\u85ac\u7269\u6fc3\u5ea6\u3092\u4e0a\u3052\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u5927\u90e8\u5206\u304c\u514b\u670d\u3055\u308c\u3066\u3044\u308b\u3002 [20]. <strong>GC376\u306f\u57f9\u990a\u4e2d\u306eFIP\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u6700\u3082\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u3072\u3068\u3064\u3067\u3042\u308b[17]<\/strong>\u3001\u6295\u4e0e\u91cf\u3092\u6570\u500d\u306b\u5897\u3084\u3057\u3066\u3082\u3053\u308c\u3089\u306e\u90e8\u4f4d\u306b\u5341\u5206\u306a\u85ac\u5264\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u305f\u3081\u3001<strong>\u773c\u3084\u795e\u7d4c\u6027\u306eFIP\u306b\u306f\u52b9\u679c\u304c\u306a\u3044<\/strong>\u3002 [14]. \u5e78\u3044\u3001EIDD-1931\u306f\u3001VEEV\u611f\u67d3\u99ac\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u8133\u5185\u3067\u6709\u52b9\u306a\u30ec\u30d9\u30eb\u306b\u9054\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u3067\u3042\u308b[3]\u3002 \u85ac\u5264\u8010\u6027\u3082\u307e\u305f\u3001GS-441524\u3067\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u4e00\u90e8\u306e\u732b\u3001\u7279\u306bFIP\u306e\u795e\u7d4c\u578b\u306b\u898b\u3089\u308c\u308b\u554f\u984c\u3067\u3042\u308b\u3002 \u6cbb\u7642\u671f\u9593\u304c\u9577\u304f\u3001\u8133\u5185\u306b\u5341\u5206\u306a\u85ac\u5264\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u305f\u3081\u3001\u85ac\u5264\u8010\u6027\u304c\u751f\u3058\u3084\u3059\u3044\u3002<\/p>\n<p class=\"p2\">\u88ab\u9a13\u85ac\u304c\u4eba\u3084\u52d5\u7269\u306b\u53ca\u307c\u3059\u77ed\u671f\u7684\u30fb\u9577\u671f\u7684\u306a\u6bd2\u6027\u4f5c\u7528\u306f\u6700\u3082\u91cd\u8981\u3067\u3042\u308b\u3002 GS-441524\u306f\u7d30\u80de\u57f9\u990a\u306b\u304a\u3044\u3066GC376\u3001EIDD-1931\u3001EIDD-2801\u3088\u308a\u3082\u6bd2\u6027\u304c\u4f4e\u3044[15] \u3002 \u3057\u304b\u3057\u3001\u6700\u3082\u91cd\u8981\u306a\u306e\u306f<i>\u751f\u4f53 <\/i>\u5185\u3067\u8d77\u3053\u308b\u6bd2\u6027\u3067\u3042\u308b\u3002<strong>GC376\u306f\u65e2\u77e5\u306e\u85ac\u5264\u306e\u4e2d\u3067\u6700\u3082\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u306e\u3072\u3068\u3064\u3067\u3042\u308b[15] \u304c\u3001\u5e7c\u3044\u5b50\u732b\u306b\u6295\u4e0e\u3059\u308b\u3068\u6210\u732b\u306e\u6b6f\u5217\u5f62\u6210\u3092\u9045\u3089\u305b\u308b[13] \u3002<\/strong> <strong>GS-441524\u306e\u91ce\u5916\u4f7f\u7528\u3067\u7d043\u5e74\u9593\u3001\u6df1\u523b\u306a\u6bd2\u6027\u306f\u89b3\u5bdf\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u3001\u3053\u308c\u306fin vitro\u3067400uM\uff08[18] \uff09\u3068\u3044\u3046\u9ad8\u6fc3\u5ea6\u3067\u3082\u7d30\u80de\u6bd2\u6027\u4f5c\u7528\u304c\u5168\u304f\u306a\u3044\u3053\u3068\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u3002 \u3057\u304b\u3057\u3001EIDD-1931\u3068EIDd-2801\u306f100uM\u3067\u6709\u610f\u306a\u7d30\u80de\u6bd2\u6027\u3092\u793a\u3057\u305f\u3002<\/strong> [15]. \u3057\u305f\u304c\u3063\u3066\u3001RNA\u306b\u81f4\u547d\u7684\u306a\u7a81\u7136\u5909\u7570\u3092\u8d77\u3053\u3059EIDD-1931\u306e\u80fd\u529b\u3053\u305d\u304c\u3001\u4ee5\u524d\u304b\u3089\u6700\u3082\u61f8\u5ff5\u3055\u308c\u3066\u304d\u305f\u3053\u3068\u3067\u3042\u308b [8, 21, 22]\u3002 \u3053\u308c\u304c\u3001\u75c5\u6c17\u3078\u306e\u9069\u7528\u304c\u9045\u308c\u3066\u3044\u308b\u5927\u304d\u306a\u7406\u7531\u3067\u3042\u308b\u3002 \u3057\u304b\u3057\u3001\u73fe\u5728\u63a8\u5968\u3055\u308c\u3066\u3044\u308bCovid-19\u306e\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u6cbb\u7642\u306e\u521d\u671f\u6bb5\u968e\u3067\u306f\u308f\u305a\u304b5\u65e5\u9593\u3067\u3042\u308b[10] \u3002 \u3057\u304b\u3057\u3001FIP\u306b\u5bfe\u3059\u308bGS-441524\u306e\u63a8\u5968\u6cbb\u7642\u671f\u9593\u306f12\u9031\u9593\u3067\u3042\u308b\uff08[14] \uff09\u3002 \u3057\u305f\u304c\u3063\u3066\u3001EIDD-1931\u307e\u305f\u306fEIDD-2801\u306e\u6295\u4e0e\u3092\u53d7\u3051\u3066\u3044\u308b\u732b\u306b\u3064\u3044\u3066\u306f\u3001\u77ed\u671f\u7684\u304a\u3088\u3073\u9577\u671f\u7684\u306a\u5f71\u97ff\u306b\u3064\u3044\u3066\u6ce8\u610f\u6df1\u304f\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n<p class=\"p2\">\u3053\u308c\u307e\u3067\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306f\u3059\u3079\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u85ac\u5264\u8010\u6027\u3092\u7372\u5f97\u3057\u3066\u304d\u305f\u3002 \u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306f\u3001HIV\/AIDS\u306e\u3088\u3046\u306a\u30a6\u30a4\u30eb\u30b9\u6027\u75be\u60a3\u306b\u4f7f\u7528\u3055\u308c\u308b\u4ed6\u306e\u85ac\u5264\u306b\u6bd4\u3079\u3001\u3053\u306e\u3088\u3046\u306a\u5909\u7570\u306e\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u3044\u3088\u3046\u306b\u898b\u3048\u308b\u304c\u3001\u85ac\u5264\u8010\u6027\u306b\u3064\u3044\u3066\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b[23-25] \u3002 FIP\u306e\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u732b\u306b\u304a\u3051\u308bGS-441524\u306b\u5bfe\u3059\u308b\u8010\u6027\u306f\u3001\u7279\u306b\u795e\u7d4c\u6027FIP\u306e\u732b\u3067\u3001\u8133\u306b\u5341\u5206\u306a\u85ac\u5264\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u3088\u308a\u56f0\u96e3\u306a\u5834\u5408\u306b\u3001\u3088\u308a\u9ad8\u3044\u983b\u5ea6\u3067\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b [13, 14, 20]\u3002 \u732b\u306b\u304a\u3051\u308bGS-441524\u306b\u5bfe\u3059\u308b\u8010\u6027\u3082\u307e\u305f\u3001FIP\u306e\u732b\u306f12\u9031\u9593\u4ee5\u4e0a\u6cbb\u7642\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u3088\u308a\u554f\u984c\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002\u4e00\u65b9\u3001\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\uff08\u304a\u3088\u3073\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\uff09\u306f\u3001Covid-19[16] \u306e\u521d\u671f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u671f\u306b\u306f5\u65e5\u9593\u306e\u307f\u306e\u6295\u4e0e\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002 \u85ac\u5264\u8010\u6027\u306e\u554f\u984c\u306f\u3001HIV\/AIDS\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u8010\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u7570\u306a\u308b\u85ac\u5264\u306e\u30ab\u30af\u30c6\u30eb\u3092\u540c\u6642\u306b\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u52b9\u679c\u7684\u306b\u7ba1\u7406\u3055\u308c\u3066\u304d\u305f\u3002 \u3042\u308b\u85ac\u5264\u306b\u5bfe\u3059\u308b\u85ac\u5264\u8010\u6027\u5909\u7570\u4f53\u306f\u3001\u4ed6\u306e\u85ac\u5264\u306b\u3088\u3063\u3066\u5373\u5ea7\u306b\u963b\u5bb3\u3055\u308c\u308b\u305f\u3081\u3001\u6cbb\u7642\u306b\u76f4\u9762\u3057\u305f\u969b\u306e\u967d\u6027\u9078\u629e\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u3002 \u8010\u6027\u6291\u5236\u306f\u30012\u3064\u306e\u85ac\u5264\u304c\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u306b\u95a2\u4e0e\u3059\u308b\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u653b\u6483\u3059\u308b\u5834\u5408\u306b\u7279\u306b\u5f37\u304f\u306a\u308b\u3002 \u4f8b\u3048\u3070\u3001GC376\u306f\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u5264[13] \u3001GS-441524\u306fRNA\u4f9d\u5b58\u6027RNA\u8907\u88fd\u9175\u7d20[18] \u306b\u4f5c\u7528\u3059\u308b\u3002 \u3057\u304b\u3057\u3001GC376\u306f\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3057\u3066\u3082\u3042\u307e\u308a\u5438\u53ce\u3055\u308c\u306a\u3044\u3002 \u307e\u3060\u5341\u5206\u306a\u7814\u7a76\u306f\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u3001GS-441524\u3068\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u9593\u306b\u4ea4\u5dee\u8010\u6027\u306f\u306a\u3044\u3082\u306e\u306e\u3001\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3059\u308b\u70b9\u3067\u306fGS-441524\u3068\u540c\u7a0b\u5ea6\u306e\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u3067\u3042\u308b[3]\u3002 \u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001<span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\uff08\u307e\u305f\u306f5-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\uff09\u306f\u3001\u5c06\u6765\u306eFIP\u6cbb\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u8ffd\u52a0\u85ac\u3068\u306a\u308b\u3060\u308d\u3046\u3002<\/p>\n<p class=\"p2\">\u4e88\u60f3\u901a\u308a\u3001<span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306f\u6700\u8fd1\u3001GS-441524\u306e\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u4e2d\u56fd\u306e\u8ca9\u58f2\u8005\u306b\u3088\u3063\u3066FIP\u306e\u732b\u3067\u8a66\u9a13\u3055\u308c\u3001\u4e88\u5099\u7684\u306a\u7d50\u679c\u304cFIP Warriors CZ\/SK\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8[26] \u306b\u5831\u544a\u3055\u308c\u305f\u3002 \u30d5\u30a3\u30fc\u30eb\u30c9\u30c8\u30e9\u30a4\u30a2\u30eb\u306f\u3001\u7c73\u56fd\u3001\u82f1\u56fd\u3001\u30a4\u30bf\u30ea\u30a2\u3001\u30c9\u30a4\u30c4\u3001\u30d5\u30e9\u30f3\u30b9\u3001\u65e5\u672c\u3001\u30eb\u30fc\u30de\u30cb\u30a2\u3001\u30c8\u30eb\u30b3\u3001\u4e2d\u56fd\u306e\u30da\u30c3\u30c8\u30af\u30ea\u30cb\u30c3\u30af\u3067\u53d7\u8a3a\u3057\u305f\u69d8\u3005\u306a\u81ea\u7136\u767a\u75c7\u578bFIP\u306e\u732b286\u982d\u3067\u69cb\u6210\u3055\u308c\u305f\u3002 \u8a66\u9a13\u306b\u53c2\u52a0\u3057\u305f286\u982d\u306e\u732b\u306e\u3046\u3061\u3001\u773c\u6027\uff08n=2\uff09\u3068\u795e\u7d4c\u6027\uff08n=5\uff09\u306eFIP\u3092\u767a\u75c7\u3057\u305f7\u982d\u3092\u542b\u3080\u6b7b\u4ea1\u4f8b\u306f\u306a\u304b\u3063\u305f\u3002 \u3053\u308c\u3089\u306e\u732b\u306e\u3046\u306128\u5339\u306f4\uff5e6\u9031\u9593\u306e\u6cbb\u7642\u3067\u6cbb\u7652\u3057\u3001258\u5339\u306f8\u9031\u9593\u5f8c\u306b\u6cbb\u7652\u3057\u305f\u3002 \u6cbb\u7642\u3057\u305f\u732b\u306f\u3059\u3079\u30663\uff5e5\u30f5\u6708\u5f8c\u3082\u5065\u5eb7\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u671f\u9593\u3001\u6cbb\u7652\u3057\u306a\u304b\u3063\u305f\u732b\u3067\u306f\u518d\u767a\u304c\u4e88\u60f3\u3055\u308c\u308b\u3002<span class=\"s3\">. T<\/span><span class=\"s4\">\u3053\u306e\u30c7\u30fc\u30bf\u306f\u3001\u69d8\u3005\u306aFIP\u306e\u732b\u306b\u5bfe\u3059\u308b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u793a\u3059\u6709\u529b\u306a\u8a3c\u62e0\u3068\u306a\u308b\u3002 \u3057\u304b\u3057\u3001\u3053\u306e\u30d5\u30a3\u30fc\u30eb\u30c9\u30fb\u30c8\u30e9\u30a4\u30a2\u30eb\u304c\u539f\u7a3f\u3068\u306a\u308a\u3001\u67fb\u8aad\u3092\u7d4c\u3066\u51fa\u7248\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002 \u3068\u306f\u3044\u3048\u3001\u73fe\u5728\u3067\u306fFIP\u306b\u304b\u304b\u3063\u305f\u732b\u306e\u98fc\u3044\u4e3b\u5411\u3051\u306b\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002 GS-441524\u306e\u4ed6\u306e\u5927\u624b\u8ca9\u58f2\u696d\u8005\u306e\u5c11\u306a\u304f\u3068\u30821\u793e\u3082FIP\u306b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306b\u95a2\u5fc3\u3092\u6301\u3063\u3066\u304a\u308a\u3001FIP\u306e\u732b\u306b\u5bfe\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u8ffd\u52a0\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u9700\u8981\u3092\u793a\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n<p class=\"p3\">FIP\u306e\u732b\u306b\u5bfe\u3059\u308b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u5b89\u5168\u304b\u3064\u6709\u52b9\u306a\u6295\u4e0e\u91cf\u306f\u767a\u8868\u3055\u308c\u3066\u3044\u306a\u3044\u3002 \u3057\u304b\u3057\u3001\u4e2d\u56fd\u306e\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u8ca9\u58f2\u696d\u8005\u306f\u3001Hero-2081[26] \u3068\u3044\u3046\u88fd\u54c1\u306e\u5e83\u544a\u30c1\u30e9\u30b7\u306e\u4e2d\u3067\u3001\u81ea\u7136\u767a\u75c7FIP\u306e\u732b\u306b\u304a\u3051\u308b\u30e2\u30eb\u30cc\u30d1\u30ea\u30d3\u30eb\u306e\u85ac\u7269\u52d5\u614b\u5b66\u7684\u30c7\u30fc\u30bf\u3068\u5b9f\u5730\u8a66\u9a13\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\u3002 \u3057\u304b\u3057\u3001\u3053\u306e\u60c5\u5831\u306b\u306f\u3001\u300c50mg\u9320\u300d1\u9320\u306b\u542b\u307e\u308c\u308b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u91cf\u3068\u5b9f\u969b\u306e\u6295\u4e0e\u9593\u9694\uff08q12h\u304bq24h\u304b\uff09\u304c\u660e\u78ba\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u306a\u3044\u3002 \u5e78\u3044\u306a\u3053\u3068\u306b\u3001FIP\u306e\u732b\u306b\u304a\u3051\u308b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u6295\u4e0e\u958b\u59cb\u91cf\u306e\u76ee\u5b89\u306f\u3001EIDD-1931\u3068EIDD-2801\u306ein-vitro\u7d30\u80de\u57f9\u990a\u8a66\u9a13\uff08[15] \uff09\u3068GS-441524\u306e\u5b9f\u9a13\u5ba4\u304a\u3088\u3073\u91ce\u5916\u8a66\u9a13\uff08[14,18] \uff09\u304b\u3089\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002 \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\uff08EIDD-2801\uff09\u306e\u7d30\u80de\u57f9\u990a\u306b\u304a\u3051\u308bFIPV\u306b\u5bfe\u3059\u308bEC50\u306f0.4 uM\/ul\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001GS-441524\u306eEC50\u306f\u7d041.0 uM\/ul[18] \u3067\u3042\u308b\u3002 \u4e21\u5264\u306e\u7d4c\u53e3\u5438\u53ce\u7387\u306f\u7d0440\uff5e50\uff05\u3068\u540c\u7a0b\u5ea6\u3067\u3042\u308b\u305f\u3081\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u6709\u52b9\u76ae\u4e0b\uff08SC\uff09\u6295\u4e0e\u91cf\u306f\u3001GS-441524[14] \u306e\u958b\u59cb\u7528\u91cf\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b4mg\/kg SC q24h\u306e\u7d042\u5206\u306e1\u3001\u307e\u305f\u306f2mg\/kg SC q24h\u3068\u306a\u308b\u3002 \u7d4c\u53e3\u5438\u53ce\u52b9\u7387\u304c\u4f4e\u3044\u3053\u3068\u3092\u8003\u616e\u3057\u3001<i>1\u56de\u3042\u305f\u308a\u306e <\/i>\u6295\u4e0e\u91cf\u30922\u500d\u306b\u3057\u30664mg\/kg\u309224\u6642\u9593\u3054\u3068\u306b\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3002 FIP\u306e\u732b\u306b\u5bfe\u3059\u308b\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u7d4c\u53e3\u6295\u4e0e\u958b\u59cb\u91cf\u306e\u76ee\u5b89\u306f\u3001\u5165\u624b\u53ef\u80fd\u306aCovid-19\u6cbb\u7642\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3082\u7b97\u51fa\u3067\u304d\u308b\u3002 Covid-19\u306e\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u306f\u3001Molnupiravir 200mg\u30925\u65e5\u9593\u3001q12h\u3067\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3002 \u3053\u306e\u6295\u4e0e\u91cf\u306f\u3001\u660e\u3089\u304b\u306b\u4eba\u3092\u5bfe\u8c61\u306b\u884c\u308f\u308c\u305f\u85ac\u7269\u52d5\u614b\u5b66\u7684\u7814\u7a76\u304b\u3089\u7b97\u51fa\u3055\u308c\u305f\u3082\u306e\u3067\u3001\u5e73\u5747\u7684\u306a\u4eba\u306e\u4f53\u91cd\u304c60\uff5e80kg\uff0870kg\uff09\u3067\u3042\u308c\u3070\u3001\u6709\u52b9\u963b\u5bb3\u91cf\u306f\uff5e3.0mg\/kg\u30921\u56de12\u6642\u9593\u304b\u3051\u3066\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3002 \u732b\u306e\u57fa\u790e\u4ee3\u8b1d\u91cf\u306f\u30d2\u30c8\u306e1.5\u500d\u3067\u3042\u308a\u3001\u30d2\u30c8\u3068\u732b\u306e\u7d4c\u53e3\u5438\u53ce\u91cf\u304c\u7b49\u3057\u3044\u3068\u4eee\u5b9a\u3059\u308b\u3068\u3001\u3053\u306e\u8a08\u7b97\u306b\u3088\u308b\u732b\u306e\u6700\u5c0f\u6295\u4e0e\u91cf\u306f4.5mg\/kg PO q12hr\u3068\u306a\u308b\u3002 \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u304cGS-441524\u3068\u540c\u7b49\u306e\u52b9\u7387\u3067\u8840\u6db2-\u773c\u95a2\u9580\u304a\u3088\u3073\u8840\u6db2-\u8133\u95a2\u9580\u3092\u901a\u904e\u3059\u308b\u3068\u4eee\u5b9a\u3057\u305f\u5834\u5408 [3,18]\u773c\u6027FIP\uff08\uff5e8mg\/kg PO\u3001q12h\uff09\u307e\u305f\u306f\u795e\u7d4c\u6027FIP\uff08\uff5e10mg\/kg PO\u3001q12h\uff09\u306e\u732b\u3067\u306f\u3001\u623f\u6c34\u304a\u3088\u3073\u8133\u810a\u9ac4\u6db2\u306b\u5341\u5206\u306b\u6d78\u900f\u3055\u305b\u308b\u305f\u3081\u3001\u6295\u4e0e\u91cf\u3092\uff5e1.5\u500d\u304a\u3088\u3073\uff5e2.0\u500d\u306b\u5897\u91cf\u3059\u308b\u3002 \u6cbb\u7642\u671f\u9593\u306f10\uff5e12\u9031\u9593\u3067\u3001\u6cbb\u7642\u53cd\u5fdc\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306fGS-441524\u3068\u540c\u3058\u3067\u3042\u308b[14, 20]\u3002 \u3053\u308c\u3089\u306e\u63a8\u5968\u306f\u3001\u516c\u8868\u3055\u308c\u305f\u60c5\u5831\u304b\u3089\u306e\u63a8\u5b9a\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3042\u308a\u3001\u73fe\u5834\u3067\u306e\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u4f7f\u7528\u306b\u306f\u3055\u3089\u306a\u308b\u7d4c\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 FIP\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u304cGS-441524\u3088\u308a\u3082\u5b89\u5168\u3067\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u306f\u7591\u554f\u3067\u3042\u308b\u304c\u3001\u7b2c3\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u304cGS-441524\u8010\u6027\u3092\u4e88\u9632\u3057\u305f\u308a\uff08\u8010\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u7570\u306a\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u30ab\u30af\u30c6\u30eb\u3068\u3057\u3066\uff09\u3001GS-441524\u304c\u52b9\u304b\u306a\u304f\u306a\u3063\u305f\u732b\u306e\u6cbb\u7642\u306b\u975e\u5e38\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002 <span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u6709\u52b9\u6210\u5206\u3067\u3042\u308bN4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306f\u975e\u5e38\u306b\u5f37\u529b\u306a\u5909\u7570\u539f\u3067\u3042\u308b\u305f\u3081\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u9577\u671f\u7684\u306a\u6bd2\u6027\u304c\u306a\u3044\u304b\u3069\u3046\u304b\u304c\u5927\u304d\u306a\u672a\u77e5\u6570\u3067\u3042\u308b\u3002[21] \u3001FIP\u306e\u6cbb\u7642\u671f\u9593\u306f\u30b3\u30d3\u30c3\u30c9-19\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u9577\u304f\u3001\u526f\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u3082\u5927\u304d\u3044\u3002<\/p>\n<p class=\"p3\">\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u6709\u52b9\u6210\u5206\u3067\u3042\u308bEIDD-1931\uff08N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\uff09\u304c\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3088\u308a\u3082FIP\u306e\u732b\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u8003\u616e\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u306f\u6b8b\u5ff5\u3067\u3042\u308b\u3002 EIDD-1931\u306f\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3088\u308a\u30824\u500d\u30a6\u30a4\u30eb\u30b9\u963b\u5bb3\u4f5c\u7528\u304c\u5f37\u304f\uff08EC50 0.09 vs 0.4 uM\uff09\u3001\u7d30\u80de\u6bd2\u6027\u30d1\u30fc\u30bb\u30f3\u30c8\u306f\u305d\u308c\u305e\u308c\u3084\u3084\u4f4e\u3044\uff08100 uM\u30672.3\uff05 vs 3.8\uff05\uff09[15] \u3002 N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306f\u7d4c\u53e3\u7d4c\u8def\u3067\u3082\u52b9\u7387\u3088\u304f\u5438\u53ce\u3055\u308c\u308b [3]\u304c\u3001EIDD-2801\uff08<span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\uff09\u306e\u958b\u767a\u3067\u306f\u8efd\u8996\u3055\u308c\u3066\u3044\u305f\u3002<span class=\"s5\">\u3053\u306e\u30b7\u30ca\u30ea\u30aa\u306fGS-441524\u3068\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306e\u30b7\u30ca\u30ea\u30aa\u3068\u540c\u3058\u3067\u3001\u73fe\u5728\u306e\u7814\u7a76\u3067\u306f\u524d\u8005\u304c\u6700\u826f\u306e\u5019\u88dc\u3067\u3042\u3063\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5f8c\u8005\u304c\u5546\u696d\u5316\u306b\u9078\u3070\u308c\u305f[17] \u3002 <\/span><\/p>\n<p class=\"p2\"><b>\u53c2\u8003\u6587\u732e <\/b><\/p>\n<p class=\"p2\">[1] Painter GR, Natchus MG, Cohen O, Holman W, Painter WP. \u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306b\u304a\u3051\u308b\u76f4\u63a5\u4f5c\u7528\u578b\u7d4c\u53e3\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u958b\u767a\uff1aCOVID-19\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e<span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306e\u9032\u5316\uff3b2021\u5e746\u670818\u65e5\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u5148\u884c\u516c\u958b\uff3d\u3002<i>Curr Opin Virol<\/i>. 2021;50:17-22. doi:10.1016\/j.coviro.2021.06.003<\/p>\n<p class=\"p2\">[2] Halford B. An emerging antiviral takes aim at COVID-19. c&amp;en\u306e\u30c8\u30d4\u30c3\u30af\u30b9\u3002 2020. https:\/\/cen.acs.org\/pharmaceuticals\/drug-development\/emerging-antiviral-takes-aim-COVID-19\/98\/web\/2020\/05.<\/p>\n<p class=\"p2\">[3] Painter GR, Richard A. Bowend RA, Bluemling GR et al. \u30d9\u30cd\u30ba\u30a8\u30e9\u30a6\u30de\u8133\u708e\u30a6\u30a4\u30eb\u30b9\u7d4c\u9f3b\u611f\u67d3\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u5e83\u6d3b\u6027\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a2\u30ca\u30ed\u30b0\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u6d3b\u6027\u3002 Antiviral Res. 2019, 171:104597<\/p>\n<p class=\"p2\">[4] Costantini, V.P., Whitaker, T., Barclay, L., Lee, D., McBrayer, T.R., Schinazi, R.F., Vinje,J., 2012.\u30ce\u30ed\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u985e\u4f3c\u4f53\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3002Antivir.Ther.17 (6), 981-991. https:\/\/doi.org\/10.3851\/imp2229.<\/p>\n<p class=\"p2\">[5] Ehteshami, M., Tao, S., Zandi, K., Hsiao, H.M., Jiang, Y., Hammond, E., Amblard, F., Russell, O.O., Merits, A., Schinazi, R.F., 2017. \u30c1\u30af\u30f3\u30b0\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u306e\u65b0\u898f\u963b\u5bb3\u5264\u3068\u3057\u3066\u306e\u03b2-d-N(4)-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306e\u7279\u6027\u3002 Antimicrob. Agents Chemother. 61 (4) e02395-02316. https:\/\/doi.org\/10.1128\/aac.02395-16.<\/p>\n<p class=\"p2\">[6] Stuyver, L.J., Whitaker, T., McBrayer, T.R., Hernandez-Santiago, B.I., Lostia, S., Tharnish, P.M., Ramesh, M., Chu, C.K., Jordan, R., Shi, J., Rachakonda, S., Watanabe, K.A., Otto, M.J., Schinazi, R.F., 2003. \u30a6\u30b7\u30a6\u30a4\u30eb\u30b9\u6027\u4e0b\u75e2\u75c7\u30a6\u30a4\u30eb\u30b9\u304a\u3088\u3073C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u306e\u57f9\u990a\u306b\u304a\u3051\u308b\u8907\u88fd\u3092\u963b\u5bb3\u3059\u308b\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a2\u30ca\u30ed\u30b0\u3002 Antimicrob. Agents Chemother. 47 (1), 244-254.<\/p>\n<p class=\"p2\">[7] Yoon J., Toots M, Lee S, Lee ME, et al, 2018. \u7d4c\u53e3\u3067\u6709\u52b9\u306a\u5e83\u57df\u30b9\u30da\u30af\u30c8\u30eb\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u304a\u3088\u3073\u547c\u5438\u5668\u5408\u80de\u4f53\u30a6\u30a4\u30eb\u30b9\u306e\u30a2\u30ca\u30ed\u30b0\u963b\u5bb3\u5264\u3002 Antimicrob. Agents Chemother. 2018, 62 (8):https:\/\/doi.org\/10.1128\/aac.00766-18 6<\/p>\n<p class=\"p2\">[8]. Urakova N, Kuznetsova V, Crossman DK, Sokratian A, Guthrie DB, Kolykhalov AA, et al. \u03b2-d-N4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b7\u30c1\u30b8\u30f3\u306f\u5f37\u529b\u306a\u6297\u30a2\u30eb\u30d5\u30a1\u30a6\u30a4\u30eb\u30b9\u5316\u5408\u7269\u3067\u3042\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306b\u9ad8\u30ec\u30d9\u30eb\u306e\u5909\u7570\u3092\u8a98\u5c0e\u3059\u308b\u3002 J Virol. 2018, 92:e01965-e01917. doi: 10.1128\/JVI.01965-17.<\/p>\n<p class=\"p2\">[9] Pyrc, K., Bosch, B.J., Berkhout, B., Jebbink, M.F., Dijkman, R., Rottier, P., van der Hoek,L., 2006.\u30d2\u30c8\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9NL63\u306e\u8907\u88fd\u30b5\u30a4\u30af\u30eb\u306e\u521d\u671f\u6bb5\u968e\u306b\u304a\u3051\u308b\u611f\u67d3\u306e\u963b\u5bb3\u3002Antimicrob.Agents Chemother.2006, 50(6):2000-2008. https:\/\/doi.org\/10.1128\/aac.01598-05.<\/p>\n<p class=\"p2\">[10]. \u30a6\u30a3\u30c3\u30c8\u30d5\u30a3\u30ebT. \u30b3\u30d3\u30c9-19\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306f\u3001\u653f\u5e9c\u8cc7\u91d1\u306b\u3088\u308b\u6280\u8853\u9769\u65b0\u306b\u3088\u3063\u3066\u53ef\u80fd\u306b\u306a\u3063\u305f\u3002 STAT+\u3002 https:\/\/www.statnews.com\/2021\/10\/05\/government-funding-backed-molnupiravir-possible-new-covid-19-treatment\/.<\/p>\n<p class=\"p2\">[11] Painter,G.R.\u3001Guthrie,D.B.\u3001Bluemling,G.\u3001Natchus,M.G.N4-Hydroxycytidine\u304a\u3088\u3073\u8a98\u5c0e\u4f53\u306a\u3089\u3073\u306b\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u7528\u9014\u3002 \u7c73\u56fd\u7279\u8a31\u51fa\u9858\u30012016\u5e74\u30012016\/106050 A1\u3002<\/p>\n<p class=\"p2\">[12] \u30e1\u30eb\u30af\u306e\u30cb\u30e5\u30fc\u30b9\u30ea\u30ea\u30fc\u30b9\u30012021\u5e7410\u67081\u65e5\u3002 https:\/\/www.merck.com\/news\/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat\/.<\/p>\n<p class=\"p2\">[13] Pedersen NC, Kim Y, Liu H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC, Bannasch M, Meadows JM, Chang KO. \u5f8c\u5929\u6027\u30cd\u30b3\u4f1d\u67d3\u6027\u8179\u819c\u708e\u306b\u5bfe\u3059\u308b3C\u69d8\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u5264\u306e\u6709\u52b9\u6027 J Feline Med Surg. 2018, 20(4):378-392.<\/p>\n<p class=\"p2\">[14] PedersenNC\u3001Perron M\u3001Bannasch M\u3001Montgomery E\u3001Murakami E\u3001Liepnieks M\u3001Liu H.\u81ea\u7136\u767a\u751f\u306e\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\u306e\u732b\u306e\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a2\u30ca\u30ed\u30b0GS-441524\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002 J Feline Med Surg. 2019, 21(4):271-281.<\/p>\n<p class=\"p2\">[15] \u732b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u6709\u52b9\u306a\u6297\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u85ac\u4f75\u7528\u7642\u6cd5\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u5408\u7406\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3002 2021. bioRxiv 2020.07.09.195016; doi: https:\/\/doi.org\/10.1101\/2020.07.09.195016<\/p>\n<p class=\"p2\">[16] COVID-19\u306f\u95c7\u5e02\u5834\u306e\u732b\u306e\u6cbb\u7642\u85ac\u3068\u307b\u3068\u3093\u3069\u540c\u3058\u3067\u3042\u308b\u3002 2020\u5e745\u67088\u65e5<\/p>\n<p class=\"p2\">Shutterstock \/ The Atlantic, https:\/\/www.theatlantic.com\/science\/archive\/2020\/05\/remdesivir-cats\/611341\/.<\/p>\n<p class=\"p2\">[17] \u30e4\u30f3VC\u3001\u30df\u30e5\u30e9\u30fcFL\u3002 Covid-19\u6cbb\u7642\u306b\u304a\u3051\u308b\u89aa\u30cc\u30af\u30ec\u30aa\u30b7\u30c9GS-441524\u306eRemdesivir\u306b\u5bfe\u3059\u308b\u512a\u4f4d\u6027\u3002 ACS Medicinal Chemistry Letters. 2020,<i>11 <\/i>(7):1361-1366 DOI: 10.1021\/acsmedchemlett.0c00316<\/p>\n<p class=\"p2\">[18] Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. \u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u30a2\u30ca\u30ed\u30b0GS-441524\u306f\u3001\u7d44\u7e54\u57f9\u990a\u304a\u3088\u3073\u5b9f\u9a13\u7684\u732b\u611f\u67d3\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u732b\u4f1d\u67d3\u6027\u8179\u819c\u708e\uff08FIP\uff09\u30a6\u30a4\u30eb\u30b9\u3092\u5f37\u529b\u306b\u963b\u5bb3\u3059\u308b.Vet Microbiol. 2018, 219:226-233.<\/p>\n<p class=\"p2\">[19]. \u30b3\u30e2\u30f3\u30fb\u30c9\u30ea\u30fc\u30e0\u30b9 \u4e00\u822c\u5e02\u6c11\u3002 \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u30012020\u5e748\u67084\u65e5\u3001https:\/\/www.commondreams.org\/newswire\/2020\/08\/04\/public-citizen-scientists-gilead-and-federal-scientists-have-neglected 7<\/p>\n<p class=\"p2\">[20] \u30c7\u30a3\u30c3\u30ad\u30f3\u30bd\u30f3PJ \u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\uff1aCovid-19\u6642\u4ee3\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u3002 \u30d5\u30ed\u30f3\u30c8 \u7363\u533b\u3060\u3002 \u30b5\u30a4\u3002 2020, 23: https:\/\/doi.org\/10.3389\/fvets.2020.584673<\/p>\n<p class=\"p2\">[21] <span class=\"s6\">\u03b2-d-N4-hydroxycytidine<\/span> Inhibits SARS-CoV-2 through lethal mutagenesis but Is also mutagenic to mammalian cells. J Infect Dis. 2021, 224:415-419, https:\/\/doi.org\/10.1093\/infdis\/jiab247.<\/p>\n<p class=\"p2\">[22] Cohen J, Piller C. E\u30e1\u30fc\u30eb\u304b\u3089\u3001COVID-19\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u533b\u85ac\u54c1\u306e\u80cc\u5f8c\u306b\u3042\u308b\u7e01\u6545\u4e3b\u7fa9\u306e\u5185\u90e8\u544a\u767a\u306b\u3064\u3044\u3066\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002 \u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30a4\u30f3\u30b5\u30a4\u30c0\u30fc\u30fb\u30d8\u30eb\u30b9 2020\u5e74\u3001https:\/\/www.science.org\/news\/2020\/05\/emails-offer-look-whistleblower-charges-cronyism-behind-potential-covid-19-drug\u3002<\/p>\n<p class=\"p2\">[23] Agostini ML, Andres EL, Sims AC, et al. \u6297\u30a6\u30a4\u30eb\u30b9\u5264\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\uff08GS-5734\uff09\u306b\u5bfe\u3059\u308b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u53d7\u6027\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3068\u6821\u6b63\u30a8\u30af\u30bd\u30ea\u30dc\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u3002<i>MBio <\/i>2018; 9. DOI: 10.1128\/mBio.00221-18.<\/p>\n<p class=\"p2\">[24] Szemiel AM, Merits A, Orton RJ,<i>In vitro <\/i>selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. Plos Path, 2021,https:\/\/doi.org\/10.1371\/journal.ppat.1009929 .<\/p>\n<p class=\"p2\">[25] Martinot M, Jary A, Fafi-Kremer S, et al., Emerging RNA-Dependent RNA Polymerase Mutation in Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019,<i>Clinical Infectious Diseases<\/i>, 2020;, ciaa1474, https:\/\/doi.org\/10.1093\/cid\/ciaa1474<\/p>\n<p class=\"p2\">[26] FIP\u30a6\u30a9\u30ea\u30a2\u30fc\u30ba CZ\/SK<span class=\"s7\">&#8211; EIDD-2801 <\/span>\uff08<span class=\"s1\"><span class=\"Apple-converted-space\">FIP <\/span><\/span>\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d5\u30a3\u30c3\u30d7\u732b\u306e\u98fc\u3044\u4e3b\u306e\u591a\u304f\u306f\u3001\u98fc\u3044\u732b\u306e\u6cbb\u7642\u306b\u95a2\u3057\u3066FIP\u00a0 \u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u3068GS441524\u306e\u4e21\u65b9\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u3002 \u5b9f\u969b\u306e\u3068\u3053\u308d\u3001\u3069\u3061\u3089\u306e\u6cbb\u7642\u6cd5\u3082FIP\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u3002 \u3057\u304b\u3057\u3001\u30e2\u30eb\u30cc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16941,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_glsr_average":0,"_glsr_ranking":0,"_glsr_reviews":0,"footnotes":""},"categories":[637],"tags":[],"_links":{"self":[{"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/pages\/17177"}],"collection":[{"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/comments?post=17177"}],"version-history":[{"count":0,"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/pages\/17177\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/media\/16941"}],"wp:attachment":[{"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/media?parent=17177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/categories?post=17177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fipmed.co\/ja\/wp-json\/wp\/v2\/tags?post=17177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}