{"id":17178,"date":"2024-03-28T04:32:29","date_gmt":"2024-03-28T04:32:29","guid":{"rendered":"https:\/\/fipmed.co\/%eb%aa%b0%eb%88%84%ed%94%bc%eb%9d%bc%eb%b9%84%eb%a5%b4-%ec%a0%9c3-%ed%95%ad%eb%b0%94%ec%9d%b4%eb%9f%ac%ec%8a%a4%ec%a0%9c-fip-%ec%b9%98%eb%a3%8c%ec%a0%9c%eb%a1%9c%ec%84%9c%ec%9d%98-%ed%95%ad%eb%b0%94\/"},"modified":"2024-03-28T04:32:29","modified_gmt":"2024-03-28T04:32:29","slug":"%eb%aa%b0%eb%88%84%ed%94%bc%eb%9d%bc%eb%b9%84%eb%a5%b4-%ec%a0%9c3-%ed%95%ad%eb%b0%94%ec%9d%b4%eb%9f%ac%ec%8a%a4%ec%a0%9c-fip-%ec%b9%98%eb%a3%8c%ec%a0%9c%eb%a1%9c%ec%84%9c%ec%9d%98-%ed%95%ad%eb%b0%94","status":"publish","type":"page","link":"https:\/\/fipmed.co\/ko\/%eb%aa%b0%eb%88%84%ed%94%bc%eb%9d%bc%eb%b9%84%eb%a5%b4-%ec%a0%9c3-%ed%95%ad%eb%b0%94%ec%9d%b4%eb%9f%ac%ec%8a%a4%ec%a0%9c-fip-%ec%b9%98%eb%a3%8c%ec%a0%9c%eb%a1%9c%ec%84%9c%ec%9d%98-%ed%95%ad%eb%b0%94\/","title":{"rendered":"FIP \uce58\ub8cc\ub97c \uc704\ud55c \uc138 \ubc88\uc9f8 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub85c\uc11c \ubab0\ub204\ud53c\ub77c\ube44\ub974"},"content":{"rendered":"

\ub9ce\uc740 FIP \uace0\uc591\uc774 \ubcf4\ud638\uc790\ub4e4\uc774 \uace0\uc591\uc774 \uce58\ub8cc\uc640 \uad00\ub828\ud558\uc5ec \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc640 GS441524\ub97c \ubaa8\ub450 \uace0\ub824\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc0ac\uc2e4 \ub450 \uce58\ub8cc \uc635\uc158 \ubaa8\ub450 FIP\ub97c \uce58\ub8cc\ud558\uace0 \ubc14\uc774\ub7ec\uc2a4 \ubcf5\uc81c\ub97c \uc608\ubc29\ud558\ub294 \ub370 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub294 \uc138\ud3ec \ub3c5\uc131\uc774 \uac15\ud558\uae30 \ub54c\ubb38\uc5d0 \ud2b9\ud788 \uace0\uc591\uc774\ub97c 12\uc8fc \ub3d9\uc548 \uce58\ub8cc\ud574\uc57c \ud558\ub294 \uacbd\uc6b0 \ub3c5\uc131\uc774 \uac15\ud55c \uc57d\ubb3c\uc5d0 \uc7a5\uc2dc\uac04 \ub178\ucd9c\uc2dc\ud0a4\ub294 \uac83\uc740 \uad8c\uc7a5\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. <\/span><\/span><\/p>\n


\n \uc544\ub798\ub294 “FIP \uce58\ub8cc\ub97c \uc704\ud55c \uc138 \ubc88\uc9f8 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub85c\uc11c\uc758 \ubab0\ub204\ud53c\ub77c\ube44\ub974” \ubcf4\uace0\uc11c\uc785\ub2c8\ub2e4. <\/span>
\n<\/span>\ub2d0\uc2a4 C. \ud398\ub370\ub974\uc13c DVM, \ubc15\uc0ac <\/i>2021\ub144 10\uc6d4 20\uc77c <\/span><\/i> <\/strong><\/p>\n

 <\/p>\n

\ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \uc804\uad6c \uc57d\ubb3c\uc778 \ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740 <\/span>1970\ub144\ub300 \ud6c4\ubc18 \uad6c\uc18c\ub828\uc5d0\uc11c \uc0dd\ubb3c\ubb34\uae30 \uc5f0\uad6c\uc758 \uc77c\ud658\uc73c\ub85c \uc5f0\uad6c\ub41c \uc800\ubd84\uc790(\ub274\ud074\ub808\uc624\uc2dc\ub4dc)\uc785\ub2c8\ub2e4[2]. \ucc9c\uc5f0\ub450\uc640 \uac19\uc740 \uc9c8\ubcd1\uc758 \ubb34\uae30\ud654\ub294 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uacf5\ud3ec\uc758 \ub300\uc0c1\uc774\uc5c8\uc9c0\ub9cc, \uc774\ub7ec\ud55c \ubaa9\uc801\uc73c\ub85c \ucc9c\uc5f0\ub450 \ubc14\uc774\ub7ec\uc2a4\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc740 \uc704\ud5d8\uc131\uc774 \ub108\ubb34 \ucef8\uc2b5\ub2c8\ub2e4. \ucc9c\uc5f0\ub450\ub294 \uc804 \uc138\uacc4\uc5d0\uc11c \ubc15\uba78\ub418\uc5c8\uace0, \uc0ac\uc2e4\uc0c1 \ubaa8\ub4e0 \uac00\ucd95\uc774 \uba78\uc885\ub418\uc5c8\uc73c\uba70, \ub354 \uc774\uc0c1\uc758 \uc5f0\uad6c\ub3c4 \uae08\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub85c \uc778\ud574 \ubbf8\uad6d\uacfc \uc18c\ub828\uc740 \uc0dd\ubb3c\ud559\uc801 \ubb34\uae30\ub85c\uc11c \ub2e4\ub978 RNA \ubc14\uc774\ub7ec\uc2a4\uc640 \uc774\ub97c \ubc29\uc5b4\ud558\uae30 \uc704\ud55c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc9c4\ud589\ud588\uc2b5\ub2c8\ub2e4. \ubca0\ub124\uc218\uc5d8\ub77c \ub9d0 \ub1cc\ucc99\uc218\uc5fc \ubc14\uc774\ub7ec\uc2a4(VEEV)\ub294 \uc0dd\ubb3c\ud559\uc801 \ubb34\uae30\ub85c \uc2ec\uac01\ud558\uac8c \uace0\ub824\ub41c \ucd5c\ucd08\uc758 \ubc14\uc774\ub7ec\uc2a4 \uc911 \ud558\ub098\uc600\uc2b5\ub2c8\ub2e4[3]. VEEV\ub294 \ubaa8\uae30\uc5d0 \ubb3c\ub824 \uc0ac\ub78c\uc5d0\uac8c \uc804\uc5fc\ub418\uba70 \uace0\uc5f4, \ub450\ud1b5, \ub1cc\uc5fc\uc744 \uc77c\uc73c\ud0a4\uace0 \uce58\uba85\uc801\uc77c \uc218 \uc788\ub294 \ubd80\uc885\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740 VEEV\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc5d0\ubcfc\ub77c, \uce58\ucfe4\uad6c\ub2c8\uc57c, \uc778\ud50c\ub8e8\uc5d4\uc790 \ubc14\uc774\ub7ec\uc2a4, \ub178\ub85c \ubc14\uc774\ub7ec\uc2a4, \uc18c \uc124\uc0ac \ubc14\uc774\ub7ec\uc2a4, C\ud615 \uac04\uc5fc \ubc14\uc774\ub7ec\uc2a4, \ud638\ud761\uae30 \uc138\ud3ec\uc735\ud569 \ubc14\uc774\ub7ec\uc2a4 \ub4f1 \uad11\ubc94\uc704\ud55c \uc54c\ud30c\ubc14\uc774\ub7ec\uc2a4\uc758 \ubcf5\uc81c\ub97c \uc5b5\uc81c\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. [3-8]. \uc778\uac04 \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4NL63\uc5d0 \ub300\ud55c <\/span>\ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc758 \uc5b5\uc81c \ud6a8\uacfc\uc5d0 \ub300\ud55c \ucd5c\ucd08\uc758 \ubcf4\uace0\ub294 2006\ub144\uc5d0 \uc774\ub8e8\uc5b4\uc84c\uc2b5\ub2c8\ub2e4[9]. \ucd5c\uadfc \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uad11\ubc94\uc704\ud55c \uc778\uac04 \ubc0f \ub3d9\ubb3c \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \uc5b5\uc81c \ud6a8\uacfc\uac00 \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4[8]. <\/span><\/p>\n

\ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc758 \ucd5c\uadfc \uc5ed\uc0ac\uc5d0\uc11c \uc911\uc694\ud55c \ubd80\ubd84\uc740 \uc5d0\ubaa8\ub9ac \uc2e0\uc57d \uac1c\ubc1c \uc5f0\uad6c\uc18c(EIDD)\uc5d0\uc11c \ube44\ub86f\ub418\uc5c8\uc73c\uba70[1], \uc2e4\ud5d8 \uba85\uce6d\uc740 EIDD-1931\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ubbf8\uad6d \uc815\ubd80\ub294 2004\ub144\ubd80\ud130 \uc5d0\ubaa8\ub9ac \uac19\uc740 \uae30\uad00\uc5d0\uc11c \uc54c\ud30c\ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uc5f0\uad6c\ub97c \uc704\ud574 \uc0c1\ub2f9\ud55c \uc7ac\uc815 \uc9c0\uc6d0\uc744 \uc81c\uacf5\ud588\uc73c\uba70, \ud604\uc7ac\uae4c\uc9c0\ub3c4 \uc0c1\ub2f9\ud55c \uc7ac\uc815 \uc9c0\uc6d0( [10])\uc744 \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uad6d\ubc29\uc704\ud611\uac10\uc18c\uad6d\uc740 2014\ub144\uc5d0 VEEV \ubc0f \uae30\ud0c0 \uc54c\ud30c\ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud654\ud569\ubb3c\uc744 \ucc3e\uae30 \uc704\ud574 \uc81c\ub3c4\uc801 \uc9c0\uc6d0\uc744 \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. “N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518 \ubc0f \uc720\ub3c4\uccb4 \ubc0f \uc774\uc640 \uad00\ub828\ub41c \ud56d\ubc14\uc774\ub7ec\uc2a4 \uc6a9\ub3c4”\ub294 2016\ub144 \ubbf8\uad6d \ud2b9\ud5c8 \ucd9c\uc6d0 2016\/106050 A1 [11] \uc5d0\uc11c \ub2e4\ub8e8\uc5c8\uc2b5\ub2c8\ub2e4. 2019\ub144\uc5d0\ub294 \uc778\ud50c\ub8e8\uc5d4\uc790 \uce58\ub8cc\ub97c \uc704\ud55c \ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc758 \uc5d0\uc2a4\ud14c\ub974\ud654\ub41c \uc804\uad6c \uc57d\ubb3c(EIDD-2801)\uc5d0 \ub300\ud55c \ud30c\ud2b8\ub108 \uc5f0\uad6c\ub97c \uc704\ud574 \uad6d\ub9bd \uc54c\ub808\ub974\uae30 \ubc0f \uc804\uc5fc\ubcd1 \uc5f0\uad6c\uc18c\ub85c\ubd80\ud130 \ucd94\uac00 \uc790\uae08\uc774 \uc9c0\uc6d0\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [10]. EIDD-2801\uc5d0 \ub300\ud55c \ud654\ud559\uc801 \ubcc0\uacbd\uc758 \uba85\uc2dc\ub41c \uc758\ub3c4\ub294 \uacbd\uad6c \uc0dd\uccb4 \uc774\uc6a9\ub960\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \uad81\uadf9\uc801\uc73c\ub85c \ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc774 \ub2e4\uc74c\uc744 \uc218\ud589 \ud560 \uc218 \uc788\ub3c4\ub85d\ud558\ub294 \uac83\uc774 \uc5c8\uc2b5\ub2c8\ub2e4. <\/span><\/span>\uc8fc\uc0ac\uac00 \uc544\ub2cc \uc54c\uc57d\uc73c\ub85c \ud22c\uc5ec\ud574\uc57c \ud569\ub2c8\ub2e4. 2019\/2020\ub144\uc5d0 \uc778\ud50c\ub8e8\uc5d4\uc790\uc5d0\uc11c SARS-II CoV\ub85c \uc5f0\uad6c\uc758 \ucd08\uc810\uc774 \uc804\ud658\ub418\uc5c8\uc2b5\ub2c8\ub2e4[2]. EIDD-2801\uc758 \uc0c1\uc6a9\ud654\ub294 \uc5d0\ubaa8\ub9ac \uacc4\uc5f4\uc0ac\uc778 \ub9ac\uc9c0\uc6e8\uc774 \ubc14\uc774\uc624\ud14c\ub77c\ud4e8\ud2f1\uc2a4\uc5d0 \ub9e1\uaca8\uc84c\uace0, \uc774 \ud68c\uc0ac\ub294 \uae38\uace0 \ube44\uc6a9\uc774 \ub9ce\uc774 \ub4dc\ub294 FDA \uc2b9\uc778 \uc808\ucc28\ub97c \uc704\ud574 \uba38\ud06c\uc640 \ud30c\ud2b8\ub108\uc2ed\uc744 \ub9fa\uc5c8\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \ud544\ub4dc \ud14c\uc2a4\ud2b8 \uc911\uc778 EIDD-2081 \ubc84\uc804\uc740 \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub85c \uba85\uba85\ub418\uc5c8\uc2b5\ub2c8\ub2e4. <\/span><\/p>\n

\ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \ud65c\uc131 \uc131\ubd84\uc778 \ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740 <\/span>\ub450 \uac00\uc9c0 \ud615\ud0dc\uc758 \ud0c0\ud22c\uba38\ub85c \uc874\uc7ac\ud569\ub2c8\ub2e4. \ud55c \uac00\uc9c0 \ud615\ud0dc\ub294 \ud0c4\uc18c\uc640 N-OH \uadf8\ub8f9 \uc0ac\uc774\uc5d0 \ub2e8\uc77c \uacb0\ud569\uc774 \uc788\ub294 \uc0ac\uc774\ud2f0\ub518\uc744 \ubaa8\ubc29\ud55c \uac83\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\ub518\uc744 \ubaa8\ubc29\ud55c \ub2e4\ub978 \ud615\ud0dc\uc5d0\uc11c\ub294 \ud0c4\uc18c\uc640 N-OH \uadf8\ub8f9 \uc0ac\uc774\uc5d0 \uc774\uc911 \uacb0\ud569\uc774 \uc788\ub294 \uc625\uc2dc\uba54\ub97c \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ubca0\ud0c0-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc774 \uc874\uc7ac\ud558\uba74 \ubc14\uc774\ub7ec\uc2a4 RNA \uc758\uc874\uc131 RNA \uc911\ud569\ud6a8\uc18c\ub294 \uc774\ub97c \uc2dc\ud2f0\ub518 \ub300\uc2e0 \uc6b0\ub9ac\ub518\uc73c\ub85c \uc77d\uace0 \uad6c\uc544\ub178\uc2e0 \ub300\uc2e0 \uc544\ub370\ub178\uc2e0\uc744 \uc0bd\uc785\ud569\ub2c8\ub2e4. \ud615\ud0dc \uac04 \uc804\ud658\uc740 \uc804\uc0ac \uacfc\uc815\uc5d0\uc11c \ubd88\uc77c\uce58\ub97c \uc720\ubc1c\ud558\uc5ec \ubc14\uc774\ub7ec\uc2a4 \uac8c\ub188\uc5d0 \uc218\ub9ce\uc740 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc77c\uc73c\ud0a4\uace0 \ubc14\uc774\ub7ec\uc2a4 \ubcf5\uc81c\ub97c \uc911\ub2e8\uc2dc\ud0b5\ub2c8\ub2e4[8]. <\/span><\/p>\n

\uba38\ud06c\uc758 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uac00 FDA\uc758 \uc870\uac74\ubd80 \ubc0f \uc644\uc804 \uc2b9\uc778\uc744 \ubc1b\uae30 \uc704\ud55c \uc808\ucc28\uac00 \uac00\uc18d\ud654\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uae30\uc5c5 \uc131\uba85\uc11c\uc5d0\uc11c \uba38\ud06c\ub294 \ub2e4\uc74c\uacfc \uac19\uc774 \ubc1d\ud614\uc2b5\ub2c8\ub2e4 [12] – “\uacb0\uacfc\ub97c \uc608\uc0c1\ud558\uba74\uc11c <\/i>2 <\/span><\/p>\n

\ubd80\ud130 \uba38\ud06c\ub294 \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub97c \uc0dd\uc0b0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uba38\ud06c\ub294 2021\ub144 \ub9d0\uae4c\uc9c0 1,000\ub9cc \ucf54\uc2a4\uc758 \uce58\ub8cc\uc81c\ub97c \uc0dd\uc0b0\ud560 \uc608\uc815\uc774\uba70, 2022\ub144\uc5d0\ub294 \ub354 \ub9ce\uc740 \uc6a9\ub7c9\uc744 \uc0dd\uc0b0\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. ……. . \uba38\ud06c\ub294 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uac00 \ud5c8\uac00 \ub610\ub294 \uc2b9\uc778\ub420 \uacbd\uc6b0 \uc804 \uc138\uacc4\uc5d0 \uc801\uc2dc\uc5d0 \uacf5\uae09\ud558\uae30 \uc704\ud574 \ucd5c\uc120\uc744 \ub2e4\ud558\uace0 \uc788\uc73c\uba70, \uc138\uacc4\uc740\ud589 \uad6d\uac00 \uc18c\ub4dd \uae30\uc900\uc5d0 \ub530\ub77c \ub2e8\uacc4\ubcc4 \uac00\uaca9 \ucc45\uc815 \ubc29\uc2dd\uc744 \ub3c4\uc785\ud558\uc5ec \ud32c\ub370\ubbf9\uc5d0 \ub300\ud55c \uac01\uad6d\uc758 \uc0c1\ub300\uc801\uc778 \ubcf4\uac74 \ub300\uc751 \uc7ac\uc815 \ub2a5\ub825\uc744 \ubc18\uc601\ud560 \uacc4\ud68d\uc785\ub2c8\ub2e4. …… . \uba38\ud06c\ub294 \uad11\ubc94\uc704\ud55c \uae00\ub85c\ubc8c \uc811\uadfc\uc131\uc744 \uc704\ud55c \ub178\ub825\uc758 \uc77c\ud658\uc73c\ub85c \ud604\uc9c0 \uaddc\uc81c \uae30\uad00\uc758 \uc2b9\uc778 \ub610\ub294 \uae34\uae09 \uc2b9\uc778\uc5d0 \ub530\ub77c 100\uac1c \uc774\uc0c1\uc758 \uc911\uc800\uc18c\ub4dd \uad6d\uac00(LMIC)\uc5d0\uc11c \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \uacf5\uae09\uc744 \uac00\uc18d\ud654\ud558\uae30 \uc704\ud574 \uae30\uc874 \uc81c\ub124\ub9ad \uc81c\uc870\uc5c5\uccb4\uc640 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc5d0 \ub300\ud55c \ube44\ub3c5\uc810\uc801 \uc790\ubc1c\uc801 \ub77c\uc774\uc120\uc2a4 \uacc4\uc57d\uc744 \uccb4\uacb0\ud588\ub2e4\uace0 \uc774\uc804\uc5d0 \ubc1c\ud45c\ud588\uc2b5\ub2c8\ub2e4.” <\/i>\uc774\ub7ec\ud55c ‘\uad00\ub300\ud568’\uc774 \ub3d9\ubb3c \uc0ac\uc6a9\uc5d0\ub3c4 \uc801\uc6a9\ub420 \uac00\ub2a5\uc131\uc740 \ub0ae\uc2b5\ub2c8\ub2e4. <\/span><\/p>\n

\ud604\uc7ac \ucf54\ub85c\ub09819 \ud32c\ub370\ubbf9\uc758 \uc6d0\uc778 \ubb3c\uc9c8\uc744 \uc5b5\uc81c\ud558\ub294 \uc57d\ubb3c\uc740 \uc9c0\ub09c 2\ub144 \ub3d9\uc548 \uc2e0\uc18d\ud558\uac8c \ud604\uc7a5 \ud14c\uc2a4\ud2b8\ub97c \uac70\ucce4\uc73c\uba70, \uadf8\uc911 \ud558\ub098\uc778 \ub818\ub370\uc2dc\ube44\ub974\uac00 \uc785\uc6d0 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uae30\ub85d\uc801\uc778 \uc2dc\uac04 \ub0b4\uc5d0 \uc2b9\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub294 \ucd08\uae30 \uac10\uc5fc\uc758 \uac00\uc815 \ub0b4 \uce58\ub8cc\ub97c \uc704\ud55c \uacbd\uad6c\uc6a9 \uc57d\ubb3c\ub85c \uc791\ub144\uc5d0 \uc870\uac74\ubd80 \uc2b9\uc778\uc73c\ub85c \uc804\ud658\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [12]. \uadf8\ub7ec\ub098 \uace0\uc591\uc774\uc5d0\uac8c \ud754\ud558\uace0 \ubc1c\ubcd1\ub960\uc774 \ub192\uc740 \ub610 \ub2e4\ub978 \uc9c8\ubcd1\uc778 \uace0\uc591\uc774 \uc804\uc5fc\uc131 \ubcf5\ub9c9\uc5fc(FIP)\uc5d0 \ub300\ud55c \ud6a8\uacfc\uc801\uc778 \ud56d \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4 \ud654\ud569\ubb3c\uc774 \ub354 \uc77c\ucc0d \uac1c\ubc1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc57d\ubb3c\uc5d0\ub294 \ud504\ub85c\ud14c\uc544\uc81c \uc5b5\uc81c\uc81c(GC376) [13] \uc640 \ub818\ub370\uc2dc\ube44\ub974\uc758 \ud65c\uc131 \ubaa8\ud2f0\ud504\uc778 RNA \uc758\uc874\uc131 RNA \uc911\ud569\ud6a8\uc18c \uc5b5\uc81c\uc81c(GS-441524) [14] \uac00 \uc788\uc2b5\ub2c8\ub2e4. \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub85c FIP\ub97c \uce58\ub8cc\ud558\ub294 \ub370 \uc131\uacf5\ud568\uc5d0 \ub530\ub77c \ucd5c\uadfc \uc870\uc9c1 \ubc30\uc591\uc5d0\uc11c FIPV\ub97c \uc5b5\uc81c\ud558\ub294 \ub2a5\ub825\uc5d0 \ub300\ud55c EIDD-1931\uacfc EIDD-2801\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4 [15]. FIPV\uc5d0 \ub300\ud55c EIDD-1931\uc758 \uc720\ud6a8 \ub18d\ub3c4-50%(EC50)\ub294 0.09 uM, EIDD-2801 0.4 uM \ubc0f GS-441524 0.66 Um [15] \uc785\ub2c8\ub2e4. 100 uM\uc5d0\uc11c \uc138\ud3ec \ub3c5\uc131 \ubc31\ubd84\uc728\uc740 \uc774\ub4e4 \ud654\ud569\ubb3c\uc758 \uacbd\uc6b0 \uac01\uac01 2.8, 3.8 \ubc0f 0\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c EIDD-1931\uacfc -2801\uc740 GS-441524\ubcf4\ub2e4 \ubc14\uc774\ub7ec\uc2a4 \uc5b5\uc81c\ub825\uc774 \uc57d\uac04 \ub354 \ub192\uc9c0\ub9cc \uc138\ud3ec \ub3c5\uc131\ub3c4 \ub354 \ub192\uc2b5\ub2c8\ub2e4.<\/strong> \uc774\ub7ec\ud55c \uc2e4\ud5d8\uc2e4 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 EIDD-1931\uacfc EIDD-2801\uc740 \ubaa8\ub450 FIP \uce58\ub8cc\uc5d0 \ud0c1\uc6d4\ud55c \ud6c4\ubcf4\uc774\uae30\ub3c4 \ud569\ub2c8\ub2e4. <\/span><\/p>\n

EIDD-1931\uacfc EIDD-2801\uc740 FIP \uce58\ub8cc\uc5d0 \ud070 \uac00\ub2a5\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc9c0\ub9cc, \uba87 \uac00\uc9c0 \uc7a5\uc560\ubb3c\uc774 \uc788\uc5b4 \uc870\ub9cc\uac04 \uc774 \ud654\ud569\ubb3c\uc744 \ubc95\uc801\uc73c\ub85c \uc0ac\uc6a9\ud558\uae30\ub294 \uc5b4\ub824\uc6b8 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4. \ub818\ub370\uc2dc\ube44\ub974\uc758 \ud65c\uc131 \ud615\ud0dc\uc774\uc790 \uae38\ub9ac\uc5b4\ub4dc \uc0ac\uc774\uc5b8\uc2a4\uac00 \ud2b9\ud5c8\ub97c \ubcf4\uc720\ud55c GS-441524\ub294 \ucf54\ub85c\ub09819 \ud32c\ub370\ubbf9\uc774 \ubc1c\uc0dd\ud558\uae30 \uc9c1\uc804\uc5d0 FIP\uc5d0 \uac78\ub9b0 \uace0\uc591\uc774\uc5d0\uac8c \uc0ac\uc6a9\ud558\uae30 \uc704\ud574 \uc5f0\uad6c\ub41c \uc57d\ubb3c\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc0ac\uc2a4 \uc720\uc0ac \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4\uac00 \uc544\ub2cc \uc5d0\ubcfc\ub77c \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ub818\ub370\uc2dc\ube44\ub974\uc758 \uc7a0\uc7ac\uc801 \uc0ac\uc6a9 \uac00\ub2a5\uc131\uc73c\ub85c \uc778\ud574 FIP [14] \uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub294 \uae38\ub9ac\uc5b4\ub4dc \uc0ac\uc774\uc5b8\uc2a4\uc758 \uacfc\ud559\uc790\ub4e4\uacfc \ud611\ub825\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc9c0\ub9cc, \uc774 \ud68c\uc0ac\ub294 \uc778\uac04\uc5d0\uac8c \ucf54\ub85c\ub09819\uc5d0 \ub300\ud55c \ud6e8\uc52c \ub354 \ud070 \uc2dc\uc7a5\uc774 \uc788\ub2e4\ub294 \uac83\uc774 \uba85\ubc31\ud574\uc9c0\uc790 GS-441524\uc5d0 \ub300\ud55c \ub3d9\ubb3c \uad8c\ub9ac\ub97c \uac70\ubd80\ud588\uc2b5\ub2c8\ub2e4 [16]. \ub9c8\ucc2c\uac00\uc9c0\ub85c, \uc9c0\ub09c 2~3\ub144 \ub3d9\uc548 \uc5d0\ubaa8\ub9ac, \ub9ac\uc9c0\ubc31 \ubc14\uc774\uc624\ud14c\ub77c\ud4e8\ud2f1\uc2a4, \uba38\ud06c\uc758 \uc218\uc758\ud559 \uc0ac\uc5c5\ubd80\uc5d0 \uace0\uc591\uc774\uc758 FIP\uc5d0 \ub300\ud55c EIDD-1931\uacfc EIDD-2801\uc744 \uc5f0\uad6c\ud574 \ub2ec\ub77c\uace0 \uc694\uccad\ud588\uc9c0\ub9cc \uae38\ub9ac\uc5b4\ub4dc\uac00 GS-441524\uc758 \ub3d9\ubb3c\uad8c \uc2b9\uc778\uc744 \uac70\ubd80\ud55c \uac83\uacfc \ube44\uc2b7\ud55c \uc774\uc720\ub85c \ub2f5\ubcc0\uc744 \ubc1b\uc9c0 \ubabb\ud558\uac70\ub098 \uac70\uc808\ub2f9\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 FIP \uce58\ub8cc\uc81c\uc5d0 \ub300\ud55c \uc804 \uc138\uacc4\uc758 \ud070 \uc218\uc694\ub85c \uc778\ud574 \uc911\uad6d\uc5d0\uc11c GS-441524\uc758 \ubbf8\uc2b9\uc778 \uc2dc\uc7a5\uc774 \ube60\ub974\uac8c \ud615\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uc640 \uac19\uc740 FIP \uce58\ub8cc\uc758 \ud544\uc694\uc131\uc73c\ub85c \uc778\ud574 \ucd5c\uadfc \uc911\uad6d\uc5d0\uc11c\ub3c4 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc5d0 \ub300\ud55c \uad00\uc2ec\uc774 \ub192\uc544\uc84c\uc2b5\ub2c8\ub2e4. <\/span><\/p>\n

EIDD-1931 \ubc0f EIDD-2801\/\ubab0\ub204\ud53c\ub77c\ube44\ub974, GS-441524 \ubc0f \ub818\ub370\uc2dc\ube44\ub974\uc758 \uc0c1\ud669\uc740 \uc77c\ubd80 \uc57d\ubb3c\uc774 \ub9c8\ucf00\ud305\uc744 \uc704\ud574 \ud504\ub85c\uc57d\uc73c\ub85c \uc804\ud658\ub418\ub294 \uc774\uc720\uc5d0 \ub300\ud574 \uc758\ubb38\uc744 \uc81c\uae30\ud569\ub2c8\ub2e4 [17]. \ub818\ub370\uc2dc\ube44\ub974\ub294 \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud65c\uc131\uc744 \ub192\uc774\uae30 \uc704\ud574 \uc5d0\uc2a4\ud14c\ub974\ud654\ub41c \uac83\uc73c\ub85c \uc54c\ub824\uc84c\uc9c0\ub9cc, \uace0\uc591\uc774\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc870\uc9c1 \ubc30\uc591\uc5d0\uc11c GS-441524\uc640 \ub818\ub370\uc2dc\ube44\ub974\uac00 \uc720\uc0ac\ud55c \ubc14\uc774\ub7ec\uc2a4 \uc5b5\uc81c \ud65c\uc131\uc744 \ubcf4\uc778 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4 [18]. \uadf8\ub7ec\ub098 \ub818\ub370\uc2dc\ube44\ub974\ub294 \uacbd\uad6c \uacbd\ub85c\ub85c\ub294 \ud761\uc218\uac00 \uc798 \ub418\uc9c0 \uc54a\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc838 \uc8fc\uc0ac\uc81c\ub85c\ub9cc \uc870\uac74\ubd80 \uc2b9\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. EIDD-1931\uc740 \uc5d0\uc2a4\ud14c\ub974\ud654 \uc5c6\uc774\ub3c4 \uacbd\uad6c \ud761\uc218\uc728\uc774 \ub192\ub2e4\ub294 \ucd08\uae30 \uc5f0\uad6c \uacb0\uacfc\uac00 \uc788\uc74c\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0[6], EIDD-2801\uc740 EIDD-1931\uc758 \uacbd\uad6c \ud761\uc218\uc728\uc744 \ub192\uc774\uae30 \uc704\ud574 \uac1c\ubc1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc778\uac04\uc5d0\uac8c \uc0ac\uc6a9\ud558\uae30 \uc704\ud574 GS-441524 \ub300\uc2e0 \ub818\ub370\uc2dc\ube44\ub974\ub97c \uc0c1\uc6a9\ud654\ud55c \ub3d9\uae30\ub294 \uacfc\ud559\uc801\uc73c\ub85c \uc758\ubb38\uc774 \uc81c\uae30\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud6c4\uc790\ub294 \ucd94\uac00 \uc218\uc815\uc5c6\uc774 \uc5ec\ub7ec\uba74\uc5d0\uc11c \uc6b0\uc6d4\ud55c \uac83\uc73c\ub85c \ubcf4\uc774\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4 [17]. EIDD-1931\ubcf4\ub2e4 \uc800\ub834\ud558\uace0 \ubc14\uc774\ub7ec\uc2a4 \uc5b5\uc81c\ub825\uc740 4\ubc30, \ub3c5\uc131\uc740 1\/3 \ub0ae\uc740 EIDD-2801 [15] \uc774 \uc0c1\uc6a9\ud654\ub420 \uc218 \uc788\ub294\ub370 \uc65c EIDD-2801\uc744 \ub0b4\ub193\uc740 \uac83\uc77c\uae4c\uc694? \uc774\ub7ec\ud55c \uacb0\uc815\uc5d0\ub294 \ud2b9\ud5c8\uad8c\uc758 \uac15\ub3c4\uc640 \ud2b9\ud5c8 \uc218\uba85\uc774 \ub354 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4 [16, 17, 19]. <\/span><\/p>\n

\uace0\uc591\uc774 FIP \uce58\ub8cc\uc758 \ubb38\uc81c \uc911 \ud558\ub098\ub294 \ub208\uacfc \ub208 \uc0ac\uc774\uc758 \ud608\uc561 \ubc0f \ub1cc \uc0ac\uc774\uc758 \ud608\uc561 \uc7a5\ubcbd\uc73c\ub85c, \uc9c8\ubcd1\uc774 \ub208 \ubc0f\/\ub610\ub294 \ub1cc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \ub54c \ub9e4\uc6b0 \uc911\uc694\ud574\uc9d1\ub2c8\ub2e4 [13, 14, 20]. \uc774 \ubb38\uc81c\ub294 GS-441524\ub85c \uc548\uad6c \ubc0f \uc2e0\uacbd\ud559\uc801 \ud615\ud0dc\uc758 FIP\ub97c \uce58\ub8cc\ud560 \ub54c \uc810\uc9c4\uc801\uc73c\ub85c \uc6a9\ub7c9\uc744 \uc99d\uac00\uc2dc\ucf1c \ud608\uc911 \ub18d\ub3c4\ub97c \ub192\uc774\uace0 \ub530\ub77c\uc11c \uc218\uc561 \ubc0f\/\ub610\ub294 \ub1cc\uc758 \uc57d\ubb3c \ub18d\ub3c4\ub97c \ub192\uc784\uc73c\ub85c\uc368 \uc0c1\ub2f9 \ubd80\ubd84 \uadf9\ubcf5\ub418\uc5c8\uc2b5\ub2c8\ub2e4. [20]. \ubc30\uc591\uc5d0\uc11c FIP \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \uac00\uc7a5 \uac15\ub825\ud55c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uc911 \ud558\ub098 \uc778 GC376 [17] \uc740<\/strong> \uc6a9\ub7c9\uc744 \uc5ec\ub7ec \ubc88 \ub298\ub824\ub3c4 \uc774\ub7ec\ud55c \ubd80\uc704\uc5d0 \ucda9\ubd84\ud55c \uc57d\ubb3c\uc744 \uacf5\uae09\ud560 \uc218 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \uc548\uad6c \ubc0f \uc2e0\uacbd\uacc4 FIP\uc5d0 \ud6a8\uacfc\uc801\uc774\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4<\/strong>. [14]. \ub2e4\ud589\ud788\ub3c4 VEEV\uc5d0 \uac10\uc5fc\ub41c \ub9d0\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c \uacb0\uacfc\uc5d0\uc11c \uc54c \uc218 \uc788\ub4ef\uc774 EIDD-1931\uc740 \ub1cc\uc5d0\uc11c \ud6a8\uacfc\uc801\uc778 \uc218\uc900\uc5d0 \ub3c4\ub2ec\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4[3]. \uc57d\ubb3c \ub0b4\uc131\uc740 \ud604\uc7ac GS-441524\ub85c \uce58\ub8cc \uc911\uc778 \uc77c\ubd80 \uace0\uc591\uc774, \ud2b9\ud788 \uc2e0\uacbd\ud559\uc801 \ud615\ud0dc\uc758 FIP\ub97c \uc553\uace0 \uc788\ub294 \uac1c\uccb4\uc5d0\uc11c \ub098\ud0c0\ub098\uace0 \uc788\ub294 \ub610 \ub2e4\ub978 \ubb38\uc81c\uc785\ub2c8\ub2e4. \uce58\ub8cc \uacfc\uc815\uc774 \uae38\uace0 \ub1cc\uc5d0 \ucda9\ubd84\ud55c \uc57d\ubb3c\uc744 \uacf5\uae09\ud558\uae30 \uc5b4\ub835\uae30 \ub54c\ubb38\uc5d0 \uc57d\ubb3c \ub0b4\uc131\uc774 \uc0dd\uae38 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <\/span><\/p>\n

\uc2dc\ud5d8 \ub300\uc0c1\uc790 \ub610\ub294 \ub3d9\ubb3c\uc5d0 \ub300\ud55c \ud6c4\ubcf4 \uc57d\ubb3c\uc758 \ub2e8\uae30 \ubc0f \uc7a5\uae30 \ub3c5\uc131 \uc601\ud5a5\uc774 \uac00\uc7a5 \uc911\uc694\ud569\ub2c8\ub2e4. GS-441524\ub294 \uc138\ud3ec \ubc30\uc591\uc5d0\uc11c GC376, EIDD-1931 \ubc0f EIDD-2801\ubcf4\ub2e4 \ub3c5\uc131\uc774 \ub0ae\uc2b5\ub2c8\ub2e4 [15]. \uadf8\ub7ec\ub098 \uac00\uc7a5 \uc911\uc694\ud55c \uac83\uc740 \uc0dd\uccb4 \ub0b4\uc5d0\uc11c <\/i>\ubc1c\uc0dd\ud558\ub294 \ub3c5\uc131\uc785\ub2c8\ub2e4. GC376\uc740 \uac00\uc7a5 \ub9ce\uc774 \uc54c\ub824\uc9c4 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4 \uc5b5\uc81c \uc57d\ubb3c \uc911 \ud558\ub098\uc774\uc9c0\ub9cc [15], \uc5b4\ub9b0 \uc0c8\ub07c \uace0\uc591\uc774\uc5d0\uac8c \ud22c\uc5ec\ud558\uba74 \uc131\uc778\uc758 \uce58\uc5f4\uc744 \uc9c0\uc5f0\uc2dc\ud0b5\ub2c8\ub2e4 [13].<\/strong> GS-441524\ub97c \uac70\uc758 3\ub144 \ub3d9\uc548 \ud604\uc7a5\uc5d0\uc11c \uc0ac\uc6a9\ud55c \uacb0\uacfc \uc2ec\uac01\ud55c \ub3c5\uc131\uc740 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc73c\uba70, \uc774\ub294 400 uM \ub18d\ub3c4\uc5d0\uc11c\ub3c4 \uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c \uc138\ud3ec \ub3c5\uc131 \uc601\ud5a5\uc774 \uc804\ud600 \uc5c6\ub294 \uac83\uc744 \ubc18\uc601\ud569\ub2c8\ub2e4 [18]. \uadf8\ub7ec\ub098 EIDD-1931\uacfc EIDd-2801\uc740 100 uM\uc5d0\uc11c \uc0c1\ub2f9\ud55c \ub3c5\uc131\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4.<\/strong> [15]. \ub530\ub77c\uc11c RNA\uc5d0 \uce58\uba85\uc801\uc778 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc77c\uc73c\ud0a4\ub294 EIDD-1931\uc758 \ub2a5\ub825\uc740 \ud55c\ub3d9\uc548 \uac00\uc7a5 \ud070 \uad00\uc2ec\uc0ac\uc600\uc2b5\ub2c8\ub2e4[8, 21, 22]. \uc774\uac83\uc774 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \uc801\uc6a9\uc774 \ub354\ub518 \uac00\uc7a5 \ud070 \uc774\uc720\uc600\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud604\uc7ac \uad8c\uc7a5\ub418\ub294 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \ucf54\ub85c\ub09819 \uce58\ub8cc \uae30\uac04\uc740 \uce58\ub8cc \ucd08\uae30\uc5d0 \ub2e8 5\uc77c\uc785\ub2c8\ub2e4( [10]). \uadf8\ub7ec\ub098 FIP\uc5d0 \ub300\ud55c GS-441524\uc758 \uad8c\uc7a5 \uce58\ub8cc \uae30\uac04\uc740 12\uc8fc( [14])\ub85c, \ub3c5\uc131\uc774 \ub098\ud0c0\ub0a0 \ub54c\uae4c\uc9c0 \ud6e8\uc52c \ub354 \uae34 \uc2dc\uac04\uc774 \uc18c\uc694\ub429\ub2c8\ub2e4. \ub530\ub77c\uc11c EIDD-1931 \ub610\ub294 EIDD-2801 \uce58\ub8cc\ub97c \ubc1b\ub294 \uace0\uc591\uc774\ub97c \uc8fc\uc758 \uae4a\uac8c \uad00\ucc30\ud558\uc5ec \ub2e8\uae30 \ubc0f \uc7a5\uae30 \ud6a8\uacfc\ub97c \ubaa8\ub450 \ud655\uc778\ud558\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4. <\/span><\/p>\n

\ud604\uc7ac\uae4c\uc9c0 \ubaa8\ub4e0 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub294 \ubc14\uc774\ub7ec\uc2a4 \uac8c\ub188\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub97c \ud1b5\ud574 \uc57d\ubb3c \ub0b4\uc131\uc774 \uc0dd\uacbc\uc2b5\ub2c8\ub2e4. \ub818\ub370\uc2dc\ube44\ub974\ub294 HIV\/AIDS\uc640 \uac19\uc740 \ubc14\uc774\ub7ec\uc2a4 \uc9c8\ud658\uc5d0 \uc0ac\uc6a9\ub418\ub294 \ub2e4\ub978 \uc57d\ubb3c\ubcf4\ub2e4 \uc774\ub7ec\ud55c \ub3cc\uc5f0\ubcc0\uc774\uc5d0 \ub35c \ucde8\uc57d\ud55c \uac83\uc73c\ub85c \ubcf4\uc774\uc9c0\ub9cc, \uc57d\ubb3c \ub0b4\uc131\uc740 \uc798 \ubb38\uc11c\ud654\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4 [23-25]. FIP \uce58\ub8cc\ub97c \ubc1b\ub294 \uace0\uc591\uc774\uc5d0\uc11c GS-441524\uc5d0 \ub300\ud55c \ub0b4\uc131\uc740 \ud2b9\ud788 \ub1cc\uc5d0 \ucda9\ubd84\ud55c \uc57d\ubb3c\uc744 \uacf5\uae09\ud558\uae30 \uc5b4\ub824\uc6b4 \uc2e0\uacbd\ud559\uc801 FIP\ub97c \uac00\uc9c4 \uace0\uc591\uc774\uc5d0\uc11c \ub354 \uc790\uc8fc \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [13, 14, 20]. \uace0\uc591\uc774\uc758 GS-441524\uc5d0 \ub300\ud55c \ub0b4\uc131 \ub610\ud55c \ub354 \ubb38\uc81c\uac00 \ub420 \uc218 \uc788\ub294\ub370, FIP\uc5d0 \uac78\ub9b0 \uace0\uc591\uc774\ub294 \uc885\uc885 12\uc8fc \uc774\uc0c1 \uce58\ub8cc\ub97c \ubc1b\ub294 \ubc18\uba74, \ub818\ub370\uc2dc\ube44\ub974(\ubc0f \ubab0\ub204\ud53c\ub77c\ube44\ub974)\ub294 \ucf54\ub85c\ub09819\uc758 \ucd08\uae30 \ubc14\uc774\ub7ec\uc2a4 \ub2e8\uacc4\uc5d0\uc11c\ub294 5\uc77c\ub9cc \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \uad8c\uc7a5\ub418\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4 [16]. \ub0b4\uc131 \ud504\ub85c\ud30c\uc77c\uc774 \ub2e4\ub978 \uc5ec\ub7ec \uc57d\ubb3c\uc744 \ub3d9\uc2dc\uc5d0 \uc0ac\uc6a9\ud558\ub294 \uce75\ud14c\uc77c\uc744 \ud1b5\ud574 HIV\/AIDS \uce58\ub8cc\uc5d0\uc11c \uc57d\ubb3c \ub0b4\uc131 \ubb38\uc81c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uad00\ub9ac\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud55c \uc57d\ubb3c\uc5d0 \ub300\ud55c \uc57d\ubb3c \ub0b4\uc131 \ub3cc\uc5f0\ubcc0\uc774\ub294 \ub2e4\ub978 \uc57d\ubb3c\uc5d0 \uc758\ud574 \uc989\uc2dc \uc5b5\uc81c\ub418\uc5b4 \uce58\ub8cc \uc2dc \uc591\uc131 \uc120\ud0dd\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4. \ub0b4\uc131 \uc5b5\uc81c\ub294 \ub450 \uc57d\ubb3c\uc774 \ubc14\uc774\ub7ec\uc2a4 \ubcf5\uc81c\uc5d0 \uad00\uc5ec\ud558\ub294 \uc11c\ub85c \ub2e4\ub978 \ub2e8\ubc31\uc9c8\uc744 \uacf5\uaca9\ud560 \ub54c \ud2b9\ud788 \uac15\ub825\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, GC376\uc740 \ud504\ub85c\ud14c\uc544\uc81c \uc5b5\uc81c\uc81c [13] \uc774\uba70, GS-441524\ub294 RNA \uc758\uc874\uc131 RNA \ubcf5\uc81c\ud6a8\uc18c [18] \uc5d0 \uc791\uc6a9\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 GC376\uc740 \ud608\uc561-\ub1cc \uc7a5\ubcbd\uc744 \ud1b5\ud574 \uc798 \ud761\uc218\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc544\uc9c1 \ucda9\ubd84\ud55c \uc5f0\uad6c\uac00 \uc774\ub8e8\uc5b4\uc9c0\uc9c0 \uc54a\uc558\uc9c0\ub9cc, GS-441524\uc640 \ubab0\ub204\ud53c\ub77c\ube44\ub974 \uc0ac\uc774\uc5d0\ub294 \uad50\ucc28 \ub0b4\uc131\uc740 \uc5c6\uc9c0\ub9cc \ud608\uc561-\ub1cc \uc7a5\ubcbd\uc744 \ud1b5\uacfc\ud558\ub294 \ub370\ub294 GS-441524\ub9cc\ud07c \ud6a8\uacfc\uc801\uc778 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4[3]. \uc774\ub7ec\ud55c \uc810 \ub54c\ubb38\uc5d0 \ubab0\ub204\ud53c\ub77c\ube44\ub974(\ub610\ub294 5-\ud558\uc774\ub85d\uc2dc\uc2dc\ud2f0\ub518)\ub294 \ud5a5\ud6c4 FIP \uce58\ub8cc\uc5d0 \uc911\uc694\ud55c \ucd94\uac00 \uc57d\ubb3c\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc608\uc0c1\ub300\ub85c \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub294 \ucd5c\uadfc \ucd5c\uc18c \ud55c \uacf3\uc758 \uc911\uad6d GS-441524 \ud310\ub9e4\uc790\uac00 FIP\ub97c \uc553\uace0 \uc788\ub294 \uace0\uc591\uc774\ub97c \ub300\uc0c1\uc73c\ub85c \uc2e4\ud5d8\ud588\uc73c\uba70, \uc608\ube44 \uacb0\uacfc\ub294 FIP Warriors CZ\/SK \uc6f9\uc0ac\uc774\ud2b8 [26] \uc5d0 \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud604\uc7a5 \uc2dc\ud5d8\uc740 \ubbf8\uad6d, \uc601\uad6d, \uc774\ud0c8\ub9ac\uc544, \ub3c5\uc77c, \ud504\ub791\uc2a4, \uc77c\ubcf8, \ub8e8\ub9c8\ub2c8\uc544, \ud130\ud0a4, \uc911\uad6d\uc758 \ub3d9\ubb3c\ubcd1\uc6d0\uc5d0\uc11c \uc790\uc5f0\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\ub294 \ub2e4\uc591\ud55c \ud615\ud0dc\uc758 FIP\ub97c \uac00\uc9c4 286\ub9c8\ub9ac\uc758 \uace0\uc591\uc774\ub97c \ub300\uc0c1\uc73c\ub85c \uc9c4\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8\uc5d0 \ucc38\uc5ec\ud55c 286\ub9c8\ub9ac\uc758 \uace0\uc591\uc774 \uc911 \uc548\uad6c(n=2) \ubc0f \uc2e0\uacbd\uacc4(n=5) FIP\ub97c \uac00\uc9c4 7\ub9c8\ub9ac\uc758 \uace0\uc591\uc774\ub97c \ud3ec\ud568\ud558\uc5ec \uc0ac\ub9dd\ud55c \uace0\uc591\uc774\ub294 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uace0\uc591\uc774 \uc911 28\ub9c8\ub9ac\ub294 4~6\uc8fc \uce58\ub8cc \ud6c4, 258\ub9c8\ub9ac\ub294 8\uc8fc \uce58\ub8cc \ud6c4 \uc644\uce58\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uce58\ub8cc\ubc1b\uc740 \ubaa8\ub4e0 \uace0\uc591\uc774\ub294 3-5\uac1c\uc6d4 \ud6c4\uc5d0\ub3c4 \uac74\uac15\ud55c \uc0c1\ud0dc\ub97c \uc720\uc9c0\ud588\uc73c\uba70, \uc774 \uae30\uac04\uc740 \uce58\ub8cc\uac00 \uc131\uacf5\uc801\uc73c\ub85c \uc774\ub8e8\uc5b4\uc9c0\uc9c0 \uc54a\uc740 \uace0\uc591\uc774\uc758 \uacbd\uc6b0 \uc7ac\ubc1c\uc774 \uc608\uc0c1\ub418\ub294 \uae30\uac04\uc785\ub2c8\ub2e4.. T<\/span>\uadf8\uc758 \ub370\uc774\ud130\ub294 \ub2e4\uc591\ud55c \ud615\ud0dc\uc758 FIP\ub97c \uac00\uc9c4 \uace0\uc591\uc774\uc5d0 \ub300\ud55c \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774 \ud604\uc7a5 \uc2dc\ud5d8\uc740 \uc6d0\uace0 \ud615\ud0dc\ub85c \uc791\uc131\ub418\uc5b4 \ub3d9\ub8cc \uac80\ud1a0\ub97c \uc704\ud574 \uc81c\ucd9c\ub418\uace0 \ucd9c\ud310\ub418\uae30\ub97c \ud76c\ub9dd\ud569\ub2c8\ub2e4. \uadf8\ub7fc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ud604\uc7ac FIP\uac00 \uc788\ub294 \uace0\uc591\uc774\uc758 \uc18c\uc720\uc8fc\uc5d0\uac8c \ud310\ub9e4\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. GS-441524\uc758 \ub2e4\ub978 \uc8fc\uc694 \ud310\ub9e4\uc5c5\uccb4 \uc911 \ucd5c\uc18c \ud55c \uacf3\ub3c4 FIP\uc5d0 \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub97c \uc0ac\uc6a9\ud558\ub294 \ub370 \uad00\uc2ec\uc774 \uc788\uc5b4, FIP\ub97c \uc553\uace0 \uc788\ub294 \uace0\uc591\uc774\uc5d0 \ub300\ud55c \ucd94\uac00\uc801\uc778 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uc57d\ubb3c \uce58\ub8cc\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. <\/span><\/span><\/p>\n

FIP\uac00 \uc788\ub294 \uace0\uc591\uc774\uc758 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc5d0 \ub300\ud55c \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \ubcf5\uc6a9\ub7c9\uc740 \uc544\uc9c1 \ubc1c\ud45c\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc911\uad6d\uc758 \ucd5c\uc18c \ud55c \ud310\ub9e4\uc790\ub294 Hero-2081 \uc774\ub77c\ub294 \uc81c\ud488\uc758 \uad11\uace0 \uc804\ub2e8\uc9c0 [26] \uc5d0\uc11c \uc790\uc5f0\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\ub294 FIP \ub97c \uac00\uc9c4 \uace0\uc591\uc774\uc5d0 \ub300\ud55c \ubab0\ub204\ud30c\ub9ac\ube44\ub974\uc758 \uc57d\ub3d9\ud559 \ubc0f \ud604\uc7a5 \ud14c\uc2a4\ud2b8 \ub370\uc774\ud130\ub97c \uc77c\ubd80 \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774 \uc815\ubcf4\uc5d0\ub294 ’50mg \uc815\uc81c’\uc5d0 \ud3ec\ud568\ub41c \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \uc591\uacfc \uc2e4\uc81c \ud22c\uc57d \uac04\uaca9(12\uc2dc\uac04 \ub610\ub294 24\uc2dc\uac04?)\uc774 \uba85\ud655\ud558\uac8c \uba85\uc2dc\ub418\uc5b4 \uc788\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ub2e4\ud589\ud788\ub3c4 FIP \uace0\uc591\uc774\uc758 \ubab0\ub204\ud53c\ub77c\ube44\ub974 \ucd94\uc815 \uc2dc\uc791 \uc6a9\ub7c9\uc740 \ubc1c\ud45c\ub41c \uccb4\uc678 \uc138\ud3ec \ubc30\uc591 \uc5f0\uad6c\uc778 EIDD-1931 \ubc0f EIDD-2801 [15] \uacfc \uc2e4\ud5d8\uc2e4 \ubc0f \ud604\uc7a5 \uc5f0\uad6c\uc778 GS-441524 [14,18] \uc5d0\uc11c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubab0\ub204\ud53c\ub77c\ube44\ub974(EIDD-2801)\ub294 \uc138\ud3ec \ubc30\uc591\uc5d0\uc11c FIPV\uc5d0 \ub300\ud55c EC50\uc774 0.4 uM\/ul\uc778 \ubc18\uba74, GS-441524\uc758 EC50\uc740 \uc57d 1.0 uM\/ul\uc785\ub2c8\ub2e4 [18]. \ub458 \ub2e4 \uacbd\uad6c \ud761\uc218\uc728\uc774 \uc57d 40~50%\ub85c \ube44\uc2b7\ud558\ubbc0\ub85c \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \ud6a8\uacfc\uc801\uc778 \ud53c\ud558(SC) \ud22c\uc5ec\ub7c9\uc740 GS-441524 [14] \uc758 24\uc2dc\uac04 \uc2dc\uc791 \uad8c\uc7a5\ub7c9\uc778 4 mg\/kg SC \ub610\ub294 2 mg\/kg SC\uc758 \uc57d \uc808\ubc18 \uc815\ub3c4\uc785\ub2c8\ub2e4(24\uc2dc\uac04). \uacbd\uad6c \ud761\uc218\uc758 \ud6a8\uc728\uc131\uc774 \ub5a8\uc5b4\uc9c0\ub294 \uac83\uc744 \uac10\uc548\ud558\uc5ec 1\ud68c <\/i> \ud22c\uc5ec\ub7c9(PO)\uc744 \ub450 \ubc30\ub85c \ub298\ub824 4 mg\/kg PO q24\uc2dc\uac04 \ud22c\uc5ec\ud569\ub2c8\ub2e4. FIP\uac00 \uc788\ub294 \uace0\uc591\uc774\uc758 \ubab0\ub204\ud53c\ub77c\ube44\ub974 \uacbd\uad6c \ud22c\uc5ec \uc2dc\uc791 \uc6a9\ub7c9\uc740 \ucf54\ub85c\ub09819 \uce58\ub8cc \uad00\ub828 \ub370\uc774\ud130\ub97c \ud1b5\ud574 \uacc4\uc0b0\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \ucf54\ub85c\ub09819 \uce58\ub8cc \uc911\uc778 \ud658\uc790\uc5d0\uac8c\ub294 5\uc77c \ub3d9\uc548 \ubab0\ub204\ud53c\ub77c\ube44\ub974 PO q12h 200mg\uc744 \ud22c\uc5ec\ud569\ub2c8\ub2e4. \uc774 \uc6a9\ub7c9\uc740 \uc0ac\ub78c\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc57d\ub3d9\ud559 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uacc4\uc0b0\ub41c \uac83\uc73c\ub85c, \ud3c9\uade0 \uccb4\uc911\uc774 60~80kg\uc778 \uc0ac\ub78c\uc758 \uacbd\uc6b0, \ud6a8\uacfc\uc801\uc778 \uc5b5\uc81c \uc6a9\ub7c9\uc740 ~3.0 mg\/kg PO q12h\uc785\ub2c8\ub2e4. \uace0\uc591\uc774\uc758 \uae30\ucd08 \ub300\uc0ac\uc728\uc740 \uc0ac\ub78c\uc758 1.5\ubc30\uc774\uba70, \uc0ac\ub78c\uacfc \uace0\uc591\uc774\uc758 \uacbd\uad6c \ud761\uc218\uac00 \ub3d9\uc77c\ud558\ub2e4\uace0 \uac00\uc815\ud558\uba74 \uc774 \uacc4\uc0b0\uc5d0 \ub530\ub978 \uace0\uc591\uc774\uc758 \ucd5c\uc18c \ud22c\uc5ec\ub7c9\uc740 4.5mg\/kg PO q12\uc2dc\uac04\uc785\ub2c8\ub2e4. \ubab0\ub204\ud53c\ub77c\ube44\ub974\uac00 GS-441524\uc640 \ub3d9\uc77c\ud55c \ud6a8\uc728\ub85c \ud608\uc561-\uc548\uad6c \ubc0f \ud608\uc561-\ub1cc \uc7a5\ubcbd\uc744 \ud1b5\uacfc\ud55c\ub2e4\uace0 \uac00\uc815\ud569\ub2c8\ub2e4. [3,18]\uc548\uad6c(~8 mg\/kg PO, q12\uc2dc\uac04) \ub610\ub294 \uc2e0\uacbd\ud559\uc801 FIP(~10 mg\/kg PO, q12\uc2dc\uac04)\uc778 \uace0\uc591\uc774\uc758 \uacbd\uc6b0 \uc218\uc561\uacfc \ub1cc\ucc99\uc218\uc561\uc5d0 \ucda9\ubd84\ud788 \uce68\ud22c\ud560 \uc218 \uc788\ub3c4\ub85d \uc6a9\ub7c9\uc744 ~1.5\ubc30 \ubc0f ~2.0\ubc30\ub85c \ub298\ub838\uc2b5\ub2c8\ub2e4. \uce58\ub8cc \uae30\uac04\uc740 10-12\uc8fc\uc774\uba70 \uce58\ub8cc \ubc18\uc751 \ubaa8\ub2c8\ud130\ub9c1\uc740 GS-441524\uc640 \ub3d9\uc77c\ud569\ub2c8\ub2e4 [14, 20]. \uc774\ub7ec\ud55c \uad8c\uc7a5 \uc0ac\ud56d\uc740 \uacf5\uac1c\ub41c \uc815\ubcf4\uc5d0 \uadfc\uac70\ud55c \ucd94\uc815\uce58\uc774\uba70, \ud604\uc7a5\uc5d0\uc11c \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc5d0 \ub300\ud55c \ub354 \ub9ce\uc740 \uacbd\ud5d8\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \ubab0\ub204\ud53c\ub77c\ube44\ub974\uac00 FIP \uce58\ub8cc\uc5d0 \uc788\uc5b4 GS-441524\ubcf4\ub2e4 \ub354 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc77c\uc9c0\ub294 \uc758\ubb38\uc774\uc9c0\ub9cc, \uc81c3\uc758 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\uac00 GS-441524 \ub0b4\uc131(\ub0b4\uc131 \ud504\ub85c\ud30c\uc77c\uc774 \ub2e4\ub978 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uce75\ud14c\uc77c)\uc744 \uc608\ubc29\ud558\uac70\ub098 GS-441524\uc5d0 \ub354 \uc774\uc0c1 \uc798 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \uace0\uc591\uc774\ub97c \uce58\ub8cc\ud558\ub294 \ub370 \ub9e4\uc6b0 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \ud65c\uc131 \uc131\ubd84\uc778 N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740 \ub9e4\uc6b0 \uac15\ub825\ud55c \ub3cc\uc5f0\ubcc0\uc774 \uc720\ubc1c \ubb3c\uc9c8\uc774\uba70 [21] FIP\uc758 \uce58\ub8cc \uc2dc\uac04\uc774 \ucf54\ub85c\ub09819\ubcf4\ub2e4 \ud6e8\uc52c \uae38\uace0 \ubd80\uc791\uc6a9 \uac00\ub2a5\uc131\uc774 \ud06c\uae30 \ub54c\ubb38\uc5d0 \uc7a5\uae30\uc801\uc778 \ub3c5\uc131\uc774 \uc5c6\ub294\uc9c0 \uc5ec\ubd80\ub294 \uc544\uc9c1 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc740 \ud070 \ubb38\uc81c\uc785\ub2c8\ub2e4. <\/span><\/p>\n

\uc548\ud0c0\uae5d\uac8c\ub3c4 \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \ud65c\uc131 \uc131\ubd84\uc778 EIDD-1931(N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518)\uc774 \ubab0\ub204\ud53c\ub77c\ube44\ub974\ubcf4\ub2e4 \uace0\uc591\uc774 FIP \uce58\ub8cc\uc5d0 \ub354 \ub9ce\uc774 \uace0\ub824\ub418\uc9c0 \uc54a\uc740 \uac83\uc740 \uc720\uac10\uc785\ub2c8\ub2e4. EIDD-1931\uc740 \ubab0\ub204\ud53c\ub77c\ube44\ub974\ubcf4\ub2e4 \ubc14\uc774\ub7ec\uc2a4 \uc5b5\uc81c \ud6a8\uacfc\uac00 4\ubc30 \ub354 \ub192\uace0(EC50 0.09 vs 0.4 uM), \uc138\ud3ec \ub3c5\uc131 \ube44\uc728\uc740 \ub2e4\uc18c \ub0ae\uc2b5\ub2c8\ub2e4(100 uM\uc5d0\uc11c 2.3% vs 3.8%) [15]. N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740 \ub610\ud55c \uacbd\uad6c \uacbd\ub85c\ub97c \ud1b5\ud574 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ub418\ub294\ub370[3], \uc774\ub294 EIDD-2801(\ubab0\ub204\ud53c\ub77c\ube44\ub974) \uac1c\ubc1c\uc5d0\uc11c \uacbd\uc2dc\ub41c \ubd80\ubd84\uc785\ub2c8\ub2e4. \uc774 \uc2dc\ub098\ub9ac\uc624\ub294 GS-441524 \ubc0f \ub818\ub370\uc2dc\ube44\ub974\uc758 \uc2dc\ub098\ub9ac\uc624\uc640 \ub3d9\uc77c\ud558\uba70, \ud604\uc7ac \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc804\uc790\uac00 \uac00\uc7a5 \uc88b\uc740 \ud6c4\ubcf4\uc600\uc744 \uac83\uc784\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ud6c4\uc790\uac00 \uc0c1\uc6a9\ud654\ub97c \uc704\ud574 \uc120\ud0dd\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [17]. <\/span><\/span> <\/p>\n

\ucc38\uc870 <\/span><\/b><\/p>\n

[1] \ud398\uc778\ud130 GR, \ub098\ucc98\uc2a4 MG, \ucf54\ud5e8 O, \ud640\ub9cc W, \ud398\uc778\ud130 WP. \ud32c\ub370\ubbf9 \uc0c1\ud669\uc5d0\uc11c \uc9c1\uc811 \uc791\uc6a9\ud558\ub294 \uacbd\uad6c\uc6a9 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uac1c\ubc1c: COVID-19 \uce58\ub8cc\uc81c\ub85c\uc11c \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc758 \uc9c4\ud654 [\uc778\uc1c4 \uc804 \uc628\ub77c\uc778 \uac8c\uc2dc, 2021\ub144 6\uc6d4 18\uc77c]. Curr Opin Virol<\/i>. 2021;50:17-22. doi:10.1016\/j.coviro.2021.06.003 <\/span><\/p>\n

[2] \ud558\ud3ec\ub4dc B. COVID-19\ub97c \uaca8\ub0e5\ud55c \uc0c8\ub85c\uc6b4 \ud56d\ubc14\uc774\ub7ec\uc2a4. C&EN \uc8fc\uc81c. 2020. https:\/\/cen.acs.org\/pharmaceuticals\/drug-development\/emerging-antiviral-takes-aim-COVID-19\/98\/web\/2020\/05. <\/span><\/p>\n

[3] \ud398\uc778\ud130 GR, \ub9ac\ucc28\ub4dc A. \ubcf4\uc6ec\ub4dc RA, \ube14\ub8e8\ubc0d GR et al. \ube44\uac15 \ub0b4 \ubca0\ub124\uc218\uc5d8\ub77c \ub9d0 \ub1cc\uc5fc \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uc758 \uc950 \ubaa8\ub378\uc5d0\uc11c \uad11\ubc94\uc704\ud558\uac8c \ud65c\uc131\uc778 \ub9ac\ubcf4\ub274\ud074\ub808\uc624\uc0ac\uc774\ub4dc \uc720\uc0ac\uccb4\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc \ud65c\uc131. \ud56d\ubc14\uc774\ub7ec\uc2a4 \uc5f0\uad6c 2019, 171:104597 <\/span><\/p>\n

[4] Costantini, V.P., Whitaker, T., Barclay, L., Lee, D., McBrayer, T.R., Schinazi, R.F., Vinje,J., 2012. \ub178\ub85c \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ub274 \ud074\ub808\uc624 \uc2dc\ub4dc \uc720\uc0ac\uccb4\uc758 \ud56d \ubc14\uc774\ub7ec\uc2a4 \ud65c\uc131. Antivir. Ther.17 (6), 981-991. https:\/\/doi.org\/10.3851\/imp2229. <\/span><\/p>\n

[5] Ehteshami, M., Tao, S., Zandi, K., Hsiao, H.M., Jiang, Y., Hammond, E., Amblard, F., Russell, O.O., Merits, A., Schinazi, R.F., 2017. \uce58\ucfe4\uad6c\ub2c8\uc57c \ubc14\uc774\ub7ec\uc2a4\uc758 \uc0c8\ub85c\uc6b4 \uc5b5\uc81c\uc81c\ub85c\uc11c \ubca0\ud0c0-d-N(4)-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc758 \ud2b9\uc131 \ubd84\uc11d. \ud56d\uade0. \uc5d0\uc774\uc804\ud2b8 \ucf00\ubaa8\ud130. 61 (4) e02395-02316. https:\/\/doi.org\/10.1128\/aac.02395-16. <\/span><\/p>\n

[6] Stuyver, L.J., Whitaker, T., McBrayer, T.R., Hernandez-Santiago, B.I., Lostia, S., Tharnish, P.M., Ramesh, M., Chu, C.K., Jordan, R., Shi, J., Rachakonda, S., Watanabe, K.A., Otto, M.J., Schinazi, R.F., 2003. \uc18c \ubc14\uc774\ub7ec\uc2a4\uc131 \uc124\uc0ac \ubc0f C\ud615 \uac04\uc5fc \ubc14\uc774\ub7ec\uc2a4\uc758 \ubc30\uc591\uc5d0\uc11c \ubcf5\uc81c\ub97c \ucc28\ub2e8\ud558\ub294 \ub9ac\ubcf4\ub274\ud074\ub808\uc624\uc0ac\uc774\ub4dc \uc720\uc0ac\uccb4\uc785\ub2c8\ub2e4. \ud56d\uade0. \uc5d0\uc774\uc804\ud2b8 \ucf00\ubaa8\ud130. 47 (1), 244-254. <\/span><\/p>\n

[7] \uc724 \uc81c\uc774, \ud22c\uce20 \uc5e0, \uc774 \uc5d0\uc2a4, \uc774 \ubbf8, \uc678, 2018. \uacbd\uad6c\uc6a9\uc73c\ub85c \ud6a8\uacfc\uc801\uc778 \uad11\ubc94\uc704\ud55c \uc2a4\ud399\ud2b8\ub7fc\uc758 \ub9ac\ubcf4\ub274\ud074\ub808\uc624\uc0ac\uc774\ub4dc <\/span>\uc778\ud50c\ub8e8\uc5d4\uc790 \ubc0f \ud638\ud761\uae30 \uc138\ud3ec\uc735\ud569 \ubc14\uc774\ub7ec\uc2a4 \uc720\uc0ac \uc5b5\uc81c\uc81c\uc785\ub2c8\ub2e4. \ud56d\uade0. \uc5d0\uc774\uc804\ud2b8 \ucf00\ubaa8\ud130. 2018, 62 (8):https:\/\/doi.org\/10.1128\/aac.00766-18 6 <\/span><\/p>\n

[8]. \uc6b0\ub77c\ucf54\ubc14 N, \ucfe0\uc988\ub124\ucd08\ubc14 V, \ud06c\ub85c\uc2a4\ub9cc DK, \uc18c\ud06c\ub77c\ud2f0\uc548 A, \uac70\uc2a4\ub9ac DB, \ucf5c\ub9ac\uce7c\ub85c\ud504 AA \ub4f1. \u03b2-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740 \ubc14\uc774\ub7ec\uc2a4 \uac8c\ub188\uc5d0\uc11c \ub192\uc740 \uc218\uc900\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc720\ub3c4\ud558\ub294 \uac15\ub825\ud55c \ud56d\uc54c\ud30c\ubc14\uc774\ub7ec\uc2a4 \ud654\ud569\ubb3c\uc785\ub2c8\ub2e4. J Virol. 2018, 92:E01965-E01917. \ub3c4\uc774: 10.1128\/JVI.01965-17. <\/span><\/p>\n

[9] Pyrc, K., Bosch, B.J., Berkhout, B., Jebbink, M.F., Dijkman, R., Rottier, P., van der Hoek,L., 2006. \ubcf5\uc81c\uc8fc\uae30\uc758 \ucd08\uae30 \ub2e8\uacc4\uc5d0\uc11c \uc778\uac04 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4 NL63 \uac10\uc5fc \uc5b5\uc81c. \ud56d\uade0. \uc5d0\uc774\uc804\ud2b8 \ud654\ud559 \uc694\ubc95. 2006, 50(6):2000-2008. https:\/\/doi.org\/10.1128\/aac.01598-05. <\/span><\/p>\n

[10]. \ucf54\ub85c\ub09819\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc774 \uc815\ubd80 \uc9c0\uc6d0 \ud601\uc2e0\uc73c\ub85c \uac00\ub2a5\ud574\uc84c\uc744 \uac00\ub2a5\uc131\uc774 \ub192\uc2b5\ub2c8\ub2e4. STAT+. https:\/\/www.statnews.com\/2021\/10\/05\/government-funding-backed-molnupiravir-possible-new-covid-19-treatment\/. <\/span><\/p>\n

[11] \ud398\uc778\ud130, G.R., \uac70\uc2a4\ub9ac, D.B., \ube14\ub8e8\ubc0d, G., \ub098\ucc98\uc2a4, M.G. N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518 \ubc0f \uc720\ub3c4\uccb4 \ubc0f \uc774\uc640 \uad00\ub828\ub41c \ud56d\ubc14\uc774\ub7ec\uc2a4 \uc6a9\ub3c4. \ubbf8\uad6d \ud2b9\ud5c8 \ucd9c\uc6d0, 2016, 2016\/106050 A1. <\/span><\/p>\n

[12] Merck \ubcf4\ub3c4 \uc790\ub8cc, 2021\ub144 10\uc6d4 1\uc77c. https:\/\/www.merck.com\/news\/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat\/. <\/span><\/p>\n

[13] \ud398\ub370\ub974\uc13c NC, \uae40 Y, \ub9ac\uc6b0 H, \uac08\ub77c\uc2dc\ud2f0 \uce78\uce74\ub098\ub9c8\ub77c\uc9c0 AC, \uc5d0\ud06c\uc2a4\ud2b8\ub780\ud2b8 C, \uadf8\ub8e8\ud0c0\uc2a4 WC, \ubc18\ub098\uc26c M, \uba54\ub3c4\uc6b0\uc2a4 JM, \ucc3d KO. \ub2e4\uc591\ud55c \ud615\ud0dc\uc758 \ud6c4\ucc9c\uc131 \uace0\uc591\uc774 \uac10\uc5fc\uc131 \ubcf5\ub9c9\uc5fc \uce58\ub8cc\uc5d0 \ub300\ud55c 3C \uc720\uc0ac \ud504\ub85c\ud14c\uc544\uc81c \uc5b5\uc81c\uc81c\uc758 \ud6a8\ub2a5. 2018, 20(4):378-392. <\/span><\/p>\n

[14] \uc790\uc5f0\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\ub294 \uace0\uc591\uc774 \uac10\uc5fc\uc131 \ubcf5\ub9c9\uc5fc\uc5d0 \uac78\ub9b0 \uace0\uc591\uc774 \uce58\ub8cc\ub97c \uc704\ud55c \ub274\ud074\ub808\uc624\uc0ac\uc774\ub4dc \uc720\uc0ac\uccb4 GS-441524\uc758 \ud6a8\ub2a5 \ubc0f \uc548\uc804\uc131(Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H.). 2019, 21(4):271-281. <\/span><\/p>\n

[15] \ucfe1 SE, \ubcf4\uac94 H, \uce74\uc2a4\ud2f0\uc694 D. \uace0\uc591\uc774 \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ud6a8\uacfc\uc801\uc778 \ubcf5\ud569 \ud56d\ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4 \uce58\ub8cc\ubc95\uc744 \ud655\uc778\ud558\uae30 \uc704\ud55c \ud569\ub9ac\uc801 \uc811\uadfc\ubc95. 2021. bioRxiv 2020.07.09.195016; \ub3c4\uc774: https:\/\/doi.org\/10.1101\/2020.07.09.195016 <\/span><\/p>\n

[16] \uc7a5 S. \ub9ce\uc774 \uacfc\uc7a5\ub41c \ucf54\ub85c\ub09819 \uce58\ub8cc\uc81c\ub294 \uc554\uc2dc\uc7a5 \uace0\uc591\uc774 \uce58\ub8cc\uc81c\uc640 \uac70\uc758 \ub3d9\uc77c\ud569\ub2c8\ub2e4. 2020\ub144 5\uc6d4 8\uc77c <\/span><\/p>\n

Shutterstock \/ The Atlantic, https:\/\/www.theatlantic.com\/science\/archive\/2020\/05\/remdesivir-cats\/611341\/. <\/span><\/p>\n

[17] \uc580 VC, \ubbac\ub7ec FL. \ucf54\ub85c\ub09819 \uce58\ub8cc\ub97c \uc704\ud55c \ub818\ub370\uc2dc\ube44\ub974 \ub300\ube44 \ubaa8\uccb4 \ub274\ud074\ub808\uc624\uc2dc\ub4dc GS-441524\uc758 \uc7a5\uc810. ACS \uc758\uc57d \ud654\ud559 \ud3b8\uc9c0. 2020, 11 <\/i>(7):1361-1366 DOI: 10.1021\/acsmedchemlett.0c00316 <\/span><\/p>\n

[18] \uba38\ud53c BG, \ud398\ub860 M, \ubb34\ub77c\uce74\ubbf8 E, \ubc14\uc6b0\uc5b4 K, \ubc15 Y, \uc5d0\ud06c\uc2a4\ud2b8\ub780\ud2b8 C, \ub9ac\ud504\ub2c8\ud06c\uc2a4 M, \ud398\ub354\uc2a8 NC. \ub274\ud074\ub808\uc624\uc0ac\uc774\ub4dc \uc720\uc0ac\uccb4 GS-441524\ub294 \uc870\uc9c1 \ubc30\uc591 \ubc0f \uc2e4\ud5d8\uc6a9 \uace0\uc591\uc774 \uac10\uc5fc \uc5f0\uad6c\uc5d0\uc11c \uace0\uc591\uc774 \uc804\uc5fc\uc131 \ubcf5\ub9c9\uc5fc(FIP) \ubc14\uc774\ub7ec\uc2a4\ub97c \uac15\ub825\ud558\uac8c \uc5b5\uc81c\ud569\ub2c8\ub2e4.Vet Microbiol. 2018, 219:226-233. <\/span><\/p>\n

[19]. \uacf5\ud1b5\uc758 \uafc8. \uc77c\ubc18 \uc2dc\ubbfc. \ubcf4\ub3c4 \uc790\ub8cc, 2020\ub144 8\uc6d4 4\uc77c, https:\/\/www.commondreams.org\/newswire\/2020\/08\/04\/public-citizen-scientists-gilead-and-federal-scientists-have-neglected 7 <\/span><\/p>\n

[20] \ub514\ud0a8\uc2a8 PJ. \uc911\ucd94\uc2e0\uacbd\uacc4\uc758 \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc: \ucf54\ub85c\ub09819 \uc2dc\ub300\uc758 \ub3d9\ubb3c \ubaa8\ub378. \uc804\uba74. Vet. Sci. 2020, 23: https:\/\/doi.org\/10.3389\/fvets.2020.584673 <\/span><\/p>\n

[21] \u03b2-d-N4-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2dc\ud2f0\ub518\uc740<\/span> \uce58\uba85\uc801\uc778 \ub3cc\uc5f0\ubcc0\uc774 \uc720\ubc1c\uc744 \ud1b5\ud574 SARS-CoV-2\ub97c \uc5b5\uc81c\ud558\uc9c0\ub9cc \ud3ec\uc720\ub958 \uc138\ud3ec\uc5d0\ub3c4 \ub3cc\uc5f0\ubcc0\uc774 \uc720\ubc1c\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. J Infect Dis. 2021, 224:415-419, https:\/\/doi.org\/10.1093\/infdis\/jiab247. <\/span><\/p>\n

[22] \ucf54\ud5e8 J, \ud544\ub7ec C. \uc774\uba54\uc77c\uc744 \ud1b5\ud574 \uc7a0\uc7ac\uc801\uc778 \ucf54\ub85c\ub09819 \uc57d\ud488\uc758 \ubc30\ud6c4\uc5d0 \uc788\ub294 \ub0b4\ubd80 \uace0\ubc1c\uc790 \ud610\uc758\uc5d0 \ub300\ud574 \uc0b4\ud3b4\ubd05\ub2c8\ub2e4. \uacfc\ud559 \ub0b4\ubd80\uc790-\uac74\uac15. 2020, https:\/\/www.science.org\/news\/2020\/05\/emails-offer-look-whistleblower-charges-cronyism-behind-potential-covid-19-drug. <\/span><\/p>\n

[23] \uc544\uace0\uc2a4\ud2f0\ub2c8 ML, \uc548\ub4dc\ub808\uc2a4 EL, \uc2ec\uc2a4 AC, et al. \ud56d\ubc14\uc774\ub7ec\uc2a4 \ub818\ub370\uc2dc\ube44\ub974(GS-5734)\uc5d0 \ub300\ud55c \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4 \uac10\uc218\uc131\uc740 \ubc14\uc774\ub7ec\uc2a4 \uc911\ud569\ud6a8\uc18c\uc640 \uad50\uc815 \uc5d1\uc18c\ub9ac\ubcf4\ub274\ud074\ub808\uc544\uc81c\uc5d0 \uc758\ud574 \ub9e4\uac1c\ub429\ub2c8\ub2e4. MBio <\/i>2018; 9. DOI: 10.1128\/mBio.00221-18. <\/span><\/p>\n

[24] Szemiel AM, Merits A, Orton RJ, \ub818\ub370\uc2dc\ube44\ub974 <\/i>\ub0b4\uc131\uc758 \uc2dc\ud5d8\uad00 \ub0b4 \uc120\ud0dd\uc740 SARS-CoV-2\uc758 \uc9c4\ud654\uc801 \uc608\uce21 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. Plos Path, 2021,https:\/\/doi.org\/10.1371\/journal.ppat.1009929 . <\/span><\/p>\n

[25] \ub9c8\ub974\ud2f0\ub178 M, \uc81c\ub9ac A, \ud30c\ud53c-\ud06c\ub808\uba38 S \ub4f1, \ub818\ub370\uc2dc\ube44\ub974\ub85c \uce58\ub8cc\ubc1b\uc740 B\uc138\ud3ec \uba74\uc5ed \uacb0\ud54d \ud658\uc790\uc5d0\uc11c \uc2e0\uc885 RNA \uc758\uc874\uc131 RNA \uc911\ud569\ud6a8\uc18c \ubcc0\uc774 2019, \uc784\uc0c1 \uac10\uc5fc\ubcd1<\/i>, 2020;, ciaa1474, https:\/\/doi.org\/10.1093\/cid\/ciaa1474 <\/span><\/p>\n

[26] FIP \uc6cc\ub9ac\uc5b4\uc988 CZ\/SK – EIDD-2801 <\/span>(\ubab0\ub204\ud53c\ub77c\ube44\ub974) <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\ub9ce\uc740 FIP \uace0\uc591\uc774 \ubcf4\ud638\uc790\ub4e4\uc774 \uace0\uc591\uc774 \uce58\ub8cc\uc640 \uad00\ub828\ud558\uc5ec \ubab0\ub204\ud53c\ub77c\ube44\ub974\uc640 GS441524\ub97c \ubaa8\ub450 \uace0\ub824\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc0ac\uc2e4 \ub450 \uce58\ub8cc \uc635\uc158 \ubaa8\ub450 FIP\ub97c \uce58\ub8cc\ud558\uace0 \ubc14\uc774\ub7ec\uc2a4 \ubcf5\uc81c\ub97c \uc608\ubc29\ud558\ub294 \ub370 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \ubab0\ub204\ud53c\ub77c\ube44\ub974\ub294 \uc138\ud3ec \ub3c5\uc131\uc774 \uac15\ud558\uae30 \ub54c\ubb38\uc5d0 \ud2b9\ud788 \uace0\uc591\uc774\ub97c 12\uc8fc \ub3d9\uc548 \uce58\ub8cc\ud574\uc57c \ud558\ub294 \uacbd\uc6b0 \ub3c5\uc131\uc774 \uac15\ud55c \uc57d\ubb3c\uc5d0 \uc7a5\uc2dc\uac04 \ub178\ucd9c\uc2dc\ud0a4\ub294 \uac83\uc740 \uad8c\uc7a5\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc544\ub798\ub294 “FIP \uce58\ub8cc\ub97c \uc704\ud55c \uc138 \ubc88\uc9f8 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub85c\uc11c\uc758 \ubab0\ub204\ud53c\ub77c\ube44\ub974” \ubcf4\uace0\uc11c\uc785\ub2c8\ub2e4. \ub2d0\uc2a4 […]<\/p>\n","protected":false},"author":1,"featured_media":16942,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_glsr_average":0,"_glsr_ranking":0,"_glsr_reviews":0,"footnotes":""},"categories":[644],"tags":[],"_links":{"self":[{"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/pages\/17178"}],"collection":[{"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/comments?post=17178"}],"version-history":[{"count":0,"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/pages\/17178\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/media\/16942"}],"wp:attachment":[{"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/media?parent=17178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/categories?post=17178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fipmed.co\/ko\/wp-json\/wp\/v2\/tags?post=17178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}