{"id":28491,"date":"2022-12-02T08:05:01","date_gmt":"2022-12-02T08:05:01","guid":{"rendered":"https:\/\/fipmed.co\/cat-fip-treatment-medical-advancement-for-fip-saves-cats\/"},"modified":"2022-12-02T08:05:01","modified_gmt":"2022-12-02T08:05:01","slug":"cat-fip-treatment-medical-advancement-for-fip-saves-cats","status":"publish","type":"page","link":"https:\/\/fipmed.co\/sk\/cat-fip-treatment-medical-advancement-for-fip-saves-cats\/","title":{"rendered":"Lie\u010dba FIP ma\u010diek: Pokrok v lie\u010dbe FIP zachra\u0148uje ma\u010dky"},"content":{"rendered":"

Pre ma\u010dky je u\u017e k dispoz\u00edcii osved\u010den\u00e1 lie\u010dba FIP. Z d\u00f4vodu nedostato\u010dnej finan\u010dnej motiv\u00e1cie v\u0161ak v s\u00fa\u010dasnosti neexistuje \u017eiadny ofici\u00e1lne schv\u00e1len\u00fd liek na FIP u ma\u010diek<\/a>. Podporn\u00e1 lie\u010dba m\u00f4\u017ee zmierni\u0165 nepr\u00edjemn\u00e9 pocity, ale nezv\u00fd\u0161i mieru pre\u017eitia, napr\u00edklad protiz\u00e1palov\u00e9 lieky a dren\u00e1\u017e tekutiny z hrudn\u00edka a brucha. Eutan\u00e1zia bola v minulosti najlep\u0161ou mo\u017enos\u0165ou vzh\u013eadom na r\u00fdchlu a vysok\u00fa \u00famrtnos\u0165 na toto ochorenie, ale dnes je mo\u017en\u00e9 poskytn\u00fa\u0165 lie\u010dbu s vysokou mierou \u00faspe\u0161nosti. V s\u00fa\u010dasnosti sa sk\u00fama nieko\u013eko sk\u00fa\u0161an\u00fdch liekov vr\u00e1tane GS441524, GC376, CL-Pro a Remdesivir. Tieto lieky nie s\u00fa v s\u00fa\u010dasnosti pr\u00e1vne dostupn\u00e9 na klinick\u00e9 pou\u017eitie pre ma\u010dky. <\/p>\n

<\/h2>\n

ANTIVIR\u00c1LNE L\u00c1TKY (inhib\u00edtory prote\u00e1z, inhib\u00edtory polym\u00e9r\u00e1z, nukleozidov\u00e9 anal\u00f3gy)<\/strong><\/p>\n

Jedin\u00e9 lie\u010debn\u00e9 postupy, ktor\u00e9 v s\u00fa\u010dasnosti d\u00e1vaj\u00fa n\u00e1dej ma\u010dk\u00e1m s FIP<\/a>, s\u00fa GS441524, \u010do je nukleozidov\u00fd anal\u00f3g, a GC376, inhib\u00edtor prote\u00e1zy. GS441524 zost\u00e1va najlep\u0161ou mo\u017enos\u0165ou lie\u010dby FIP v\u010faka ni\u017e\u0161ej miere recid\u00edv v porovnan\u00ed s GC376. V porovnan\u00ed s liekom Remdesivir p\u00f4sob\u00ed aj r\u00fdchlej\u0161ie. Remdesivir je toti\u017e prekurzorom GS441524, tak\u017ee na to, aby Remdesivir mohol \u00fa\u010dinkova\u0165, je potrebn\u00fd \u010fal\u0161\u00ed krok, aby sa premenil na GS441524.<\/p>\n

 <\/p>\n

GS-441524<\/strong><\/p>\n

Boli poskytnut\u00e9 d\u00f4kazy, \u017ee tento liek funguje dobre v mnoh\u00fdch situ\u00e1ci\u00e1ch. Jeho z\u00edskanie bolo \u0165a\u017ek\u00e9. Remdesivir, ako u\u017e bolo uveden\u00e9, je protid alebo prolie\u010divo, ktor\u00e9 telo n\u00e1sledne transformuje na GS-441524. Pod\u00e1vanie lieku vo forme protidov alebo prolie\u010diva pom\u00e1ha dosta\u0165 ho do buniek imunitn\u00e9ho syst\u00e9mu, ktor\u00e9 obsahuj\u00fa imunosupres\u00edvne koronav\u00edrusy. Pri testovan\u00ed niektor\u00fdch liekov na ma\u010dk\u00e1ch sa GS-441524 pod\u00e1val vo svojej p\u00f4vodnej forme, pri\u010dom nebola pozorovan\u00e1 \u017eiadna \u00faspe\u0161n\u00e1 miera vylie\u010denia FIP. <\/p>\n

 <\/p>\n

GS441524 je v s\u00fa\u010dasnosti st\u00e1le najlep\u0161ou mo\u017enos\u0165ou lie\u010dby. Vzh\u013eadom na vysok\u00e9 n\u00e1klady a nedostato\u010dn\u00fd pr\u00edstup k tomuto lieku by v\u0161ak majitelia ma\u010diek mali viac tla\u010di\u0165 na to, aby ich ma\u010dka ochoreniu v\u00f4bec predi\u0161la. <\/p>\n

 <\/p>\n

GC376<\/strong><\/p>\n

GC376 mo\u017eno pova\u017eova\u0165 za \u0161irokospektr\u00e1lne antiv\u00edrusov\u00e9 lie\u010divo, ktor\u00e9 inhibuje Mpro<\/sup> viacer\u00fdch v\u00edrusov vr\u00e1tane koronav\u00edrusov, ako je FCoV, v\u00edrus epidemickej hna\u010dky o\u0161\u00edpan\u00fdch (PEDV), SARS-CoV, MERS-CoV, SARS-CoV-2, koronav\u00edrus fretky a norky. GC376 je prolie\u010divo GC373, \u010fal\u0161ieho inhib\u00edtora prote\u00e1z na b\u00e1ze dipeptidu. Lie\u010dba FIP u ma\u010diek pomocou GC376 bola spojen\u00e1 s ved\u013eaj\u0161\u00edmi \u00fa\u010dinkami, ako je prechodn\u00e9 pichanie v miestach vpichu, podko\u017en\u00e1 fibr\u00f3za, vypad\u00e1vanie srsti a abnorm\u00e1lne prerez\u00e1vanie trval\u00fdch zubov u mlad\u00fdch ma\u010diek[4]<\/span>. Preto s\u00fa potrebn\u00e9 \u010fal\u0161ie \u0161t\u00fadie na vyhodnotenie mo\u017en\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkov spojen\u00fdch s pou\u017eit\u00edm GC376 na zvierac\u00edch modeloch pred jeho pou\u017eit\u00edm v klinick\u00fdch sk\u00fa\u0161kach. GC376 zabra\u0148uje replik\u00e1cii v\u00edrusu FCoV in\u00fdm mechanizmom. Miera relapsu u ma\u010diek lie\u010den\u00fdch liekom GC376 je v\u0161ak v\u00fdrazne vy\u0161\u0161ia ako u GS441524. V pr\u00edpade, \u017ee sa u ma\u010diek vyvinula rezistencia vo\u010di GS441524, najm\u00e4 v pr\u00edpadoch relapsu, GC376 za\u017eiaril. Vtedy sa odpor\u00fa\u010da pou\u017ei\u0165 namiesto neho GC376. Existuj\u00fa aj v\u00fdskumn\u00e9 \u0161t\u00fadie, ktor\u00e9 ukazuj\u00fa, \u017ee kombin\u00e1cia GS441524 a GC376 prin\u00e1\u0161a lep\u0161ie v\u00fdsledky a umo\u017enila aj krat\u0161ie trvanie lie\u010dby 6 t\u00fd\u017ed\u0148ov namiesto obvykl\u00fdch 12 t\u00fd\u017ed\u0148ov. <\/p>\n

 <\/p>\n

Interfer\u00f3n pre ma\u010dky<\/b><\/p>\n

Interfer\u00f3n je l\u00e1tka, ktor\u00fa telo prirodzene vytv\u00e1ra ako odpove\u010f na v\u00edrusov\u00fa infekciu. Veterin\u00e1rni lek\u00e1ri maj\u00fa k dispoz\u00edcii dva druhy interfer\u00f3nov: ma\u010dac\u00ed interfer\u00f3n omega (Virbagen Omega,\u00ae vyr\u00e1ban\u00fd spolo\u010dnos\u0165ou Virbac vo Franc\u00fazsku) a \u013eudsk\u00fd interfer\u00f3n alfa, ktor\u00fd sa dod\u00e1va pod nieko\u013ek\u00fdmi zna\u010dkami. Uprednost\u0148uje sa pou\u017e\u00edvanie ma\u010dacieho interfer\u00f3nu, preto\u017ee interfer\u00f3ny s\u00fa druhovo \u0161pecifick\u00e9: najlep\u0161ie \u00fa\u010dinkuj\u00fa u druhu, z ktor\u00e9ho poch\u00e1dzaj\u00fa. Interfer\u00f3n-omega je injekcia pred\u00e1van\u00e1 pre ma\u010dky s FIP. Mal\u00e1 skor\u00e1 \u0161t\u00fadia uk\u00e1zala s\u013eubn\u00e9 v\u00fdsledky, a tak sa na kr\u00e1tke obdobie stal s\u00fa\u010das\u0165ou \u0161tandardnej lie\u010dby. Bola to jedna z prv\u00fdch dostupn\u00fdch met\u00f3d lie\u010dby FIP<\/a>, av\u0161ak \u00faspe\u0161nos\u0165 bola n\u00edzka. V\u00e4\u010d\u0161ia dvojito zaslepen\u00e1 placebom kontrolovan\u00e1 \u0161t\u00fadia nezistila \u017eiadny pr\u00ednos interfer\u00f3nu. T\u00fdm sa mala z\u00e1le\u017eitos\u0165 skon\u010di\u0165, ale liek je st\u00e1le dostupn\u00fd a \u013eudia st\u00e1le presadzuj\u00fa skor\u0161\u00ed dokument bez odkazu na ten neskor\u0161\u00ed. <\/p>\n

 <\/p>\n

KORTIKOSTEROIDY (LEN PRE PALLIALITIVE)<\/strong><\/p>\n

Po\u010das po\u010diato\u010dn\u00e9ho \u0161t\u00e1dia ochorenia m\u00f4\u017ee by\u0165 potrebn\u00e1 podporn\u00e1 (symptomatick\u00e1) lie\u010dba, aby sa ma\u010dky udr\u017eali pri \u017eivote dostato\u010dne dlho na to, aby antivirotik\u00e1 za\u010dali p\u00f4sobi\u0165.
\nMedzi lieky sa \u010dasto zara\u010fuj\u00fa protiz\u00e1palov\u00e9 lieky (kortikosteroidy, NSAID).
\nJe vhodnej\u0161ie vyhn\u00fa\u0165 sa nadmern\u00e9mu pou\u017e\u00edvaniu t\u00fdchto liekov, pokia\u013e sa nepou\u017e\u00edvaj\u00fa kr\u00e1tkodobo a len v pr\u00edpade, \u017ee existuje presved\u010div\u00fd d\u00f4vod na ich pou\u017eitie, najm\u00e4 u extr\u00e9mne chor\u00fdch ma\u010diek po\u010das prv\u00fdch dn\u00ed. <\/span><\/p>\n

Hlavn\u00fdm cie\u013eom lie\u010dby FIP je zabr\u00e1ni\u0165 replik\u00e1cii v\u00edrusu v makrof\u00e1goch, \u010d\u00edm sa okam\u017eite zastav\u00ed tvorba r\u00f4znych z\u00e1palov\u00fdch a imunosupres\u00edvnych cytok\u00ednov, ktor\u00e9 vyvol\u00e1vaj\u00fa pr\u00edznaky FIP.
\nZatia\u013e \u010do niektor\u00e9 lieky, ako s\u00fa kortikosteroidy (prednizol\u00f3n) a NSAID (meloxikam), m\u00f4\u017eu zn\u00ed\u017ei\u0165 mno\u017estvo z\u00e1palov\u00fdch cytok\u00ednov, GS-441524 tieto \u0161kodliv\u00e9 cytok\u00edny \u00faplne blokuje.
\nV priebehu 24-48 hod\u00edn FipMed vyvol\u00e1 v\u00fdrazn\u00e9 zlep\u0161enie teploty, aktivity, hladu a \u010fal\u0161\u00edch pr\u00edznakov.
\nToto zlep\u0161enie bude podstatne v\u00e4\u010d\u0161ie, ako m\u00f4\u017ee poskytn\u00fa\u0165 ak\u00fdko\u013evek in\u00fd liek.
\nV d\u00f4sledku toho, ak neexistuje z\u00e1va\u017en\u00fd d\u00f4vod na pokra\u010dovanie v pou\u017e\u00edvan\u00ed in\u00fdch liekov, mali by sa vysadi\u0165 hne\u010f, ako sa dostav\u00ed vidite\u013en\u00e9 a trval\u00e9 zlep\u0161enie pr\u00edznakov FIP<\/a>. <\/span><\/p>\n

Okrem maskovania pr\u00edznakov s\u00favisiacich s FIP m\u00f4\u017eu steroidy zasahova\u0165 do distrib\u00facie lieku GS-441524 cez hematoencefalick\u00fa bari\u00e9ru.
\nNieko\u013eko v\u00fdskumov preuk\u00e1zalo, \u017ee steroidy m\u00f4\u017eu zn\u00ed\u017ei\u0165 priepustnos\u0165 cez hematoencefalick\u00fa bari\u00e9ru.
\nU ma\u010diek m\u00f4\u017ee zn\u00ed\u017een\u00e1 priepustnos\u0165 zn\u00ed\u017ei\u0165 \u00fa\u010dinnos\u0165 GS-441524 a zv\u00fd\u0161i\u0165 pravdepodobnos\u0165 relapsu. <\/span><\/p>\n

 <\/p>\n

GS 441524<\/a> Bezpe\u010dnos\u0165 ako lie\u010dba FIP<\/b><\/span><\/p>\n

GS-441524 sa uk\u00e1zal ako bezpe\u010dn\u00e1 a \u00fa\u010dinn\u00e1 mo\u017enos\u0165 lie\u010dby.
\nTento liek bol p\u00f4vodne vyvinut\u00fd ako antiv\u00edrusov\u00e1 lie\u010dba pre \u013eud\u00ed, ale odvtedy bol op\u00e4tovne pou\u017eit\u00fd na pou\u017eitie u ma\u010diek. <\/span><\/span><\/p>\n

Viacer\u00e9 \u0161t\u00fadie preuk\u00e1zali, \u017ee liek nesp\u00f4sobuje v\u00fdznamn\u00e9 ne\u017eiaduce \u00fa\u010dinky alebo toxicitu, ak sa pod\u00e1va pod\u013ea pokynov.<\/span><\/p>\n

Niektor\u00e9 ma\u010dky m\u00f4\u017eu po\u010das lie\u010dby poci\u0165ova\u0165 mierne ved\u013eaj\u0161ie \u00fa\u010dinky, ako je nevo\u013enos\u0165 alebo letargia. Tieto pr\u00edznaky zvy\u010dajne r\u00fdchlo ust\u00fapia a nevy\u017eaduj\u00fa si z\u00e1sah veterin\u00e1rneho lek\u00e1ra. <\/span><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Pre ma\u010dky je u\u017e k dispoz\u00edcii osved\u010den\u00e1 lie\u010dba FIP. Z d\u00f4vodu nedostato\u010dnej finan\u010dnej motiv\u00e1cie v\u0161ak v s\u00fa\u010dasnosti neexistuje \u017eiadny ofici\u00e1lne schv\u00e1len\u00fd liek na FIP u ma\u010diek. Podporn\u00e1 lie\u010dba m\u00f4\u017ee zmierni\u0165 nepr\u00edjemn\u00e9 pocity, ale nezv\u00fd\u0161i mieru pre\u017eitia, napr\u00edklad protiz\u00e1palov\u00e9 lieky a dren\u00e1\u017e tekutiny z hrudn\u00edka a brucha. Eutan\u00e1zia bola v minulosti najlep\u0161ou mo\u017enos\u0165ou vzh\u013eadom na r\u00fdchlu […]<\/p>\n","protected":false},"author":11,"featured_media":28494,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_glsr_average":0,"_glsr_ranking":0,"_glsr_reviews":0,"footnotes":""},"categories":[1169],"tags":[1170,1192],"_links":{"self":[{"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/pages\/28491"}],"collection":[{"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/comments?post=28491"}],"version-history":[{"count":0,"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/pages\/28491\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/media\/28494"}],"wp:attachment":[{"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/media?parent=28491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/categories?post=28491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fipmed.co\/sk\/wp-json\/wp\/v2\/tags?post=28491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}